Zobrazeno 1 - 10
of 363
pro vyhledávání: '"Derk Frank"'
Autor:
Merve Keles, Steve Grein, Natali Froese, Dagmar Wirth, Felix A. Trogisch, Rhys Wardman, Shruthi Hemanna, Nina Weinzierl, Philipp-Sebastian Koch, Stefanie Uhlig, Santosh Lomada, Gesine M. Dittrich, Malgorzata Szaroszyk, Ricarda Haustein, Jan Hegermann, Abel Martin-Garrido, Johann Bauersachs, Derk Frank, Norbert Frey, Karen Bieback, Julio Cordero, Gergana Dobreva, Thomas Wieland, Joerg Heineke
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 3, Pp 102306- (2024)
Pathological cardiac remodeling predisposes individuals to developing heart failure. Here, we investigated two co-regulated long non-coding RNAs (lncRNAs), termed Gadlor1 and Gadlor2, which are upregulated in failing hearts of patients and mice. Card
Externí odkaz:
https://doaj.org/article/35dc9f1f1a1a4ecda9219b0bc2786a74
Autor:
Rafael Henrique Rangel, Jakob Christoph Voran, Hatim Seoudy, Theresa Villinger, G. Lutter, T. Puehler, Felix Kreidel, Johanne Frank, Mostafa Salem, Derk Frank, Mohammed Saad
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 53, Iss , Pp 101416- (2024)
Objectives: To investigate the change in severity of mitral regurgitation (MR) after transcatheter aortic valve replacement (TAVR) and its effect on 5-year mortality. Background: There is inconsistency in literature on pre-existing MR influencing lon
Externí odkaz:
https://doaj.org/article/afc8b910cb654ba5b4aabc370b2ebc73
Autor:
Marie Noormalal, Nesrin Schmiedel, Tarik Bozoglu, Andrea Matzen, Susanne Hille, Dima Ibrahim Basha, Prithviraj Manohar Vijaya Shetty, Anja Wolf, Marcin Zaradzki, Rawa Arif, Thomas Pühler, Georg Lutter, Andreas H. Wagner, Christian Kupatt, Derk Frank, Norbert Frey, Anca Remes, Oliver J. Müller
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101163- (2024)
Rupture or dissection of thoracic aortic aneurysms is still the leading cause of death for patients diagnosed with Marfan syndrome. Inflammation and matrix digestion regulated by matrix metalloproteases (MMPs) play a major role in the pathological re
Externí odkaz:
https://doaj.org/article/49ac9d0be7fc467286fe61422e59094f
Autor:
Steffen Wundram, Hatim Seoudy, Johannes C. Dümmler, Lukas Ritter, Johanne Frank, Thomas Puehler, Georg Lutter, Matthias Lutz, Mohammed Saad, Peter Bramlage, Janarthanan Sathananthan, David A. Wood, Sandra B. Lauck, Norbert Frey, Derk Frank
Publikováno v:
BMC Cardiovascular Disorders, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background Transcatheter aortic valve implantation (TAVI) can either be conducted as an elective (scheduled in advance) or a non-elective procedure performed during an unplanned hospital admission. The objective of this study was to compare
Externí odkaz:
https://doaj.org/article/14892dd705b74c21bc1b97bae3ca5802
Autor:
Anca Remes, Marie Noormalal, Nesrin Schmiedel, Norbert Frey, Derk Frank, Oliver J. Müller, Markus Graf
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Pathological remodeling of the extracellular matrix is a hallmark of cardiovascular disease. Abnormal fibrosis causes cardiac dysfunction by reducing ejection fraction and impairing electrical conductance, leading to arrhythmias. Hence, accu
Externí odkaz:
https://doaj.org/article/4517ff33e1e6403faa08f301033d0786
Autor:
Matthias Petersen, Nesrin Schmiedel, Franziska Dierck, Susanne Hille, Anca Remes, Frauke Senger, Inga Schmidt, Renate Lüllmann-Rauch, Oliver J. Müller, Derk Frank, Ashraf Y. Rangrez, Norbert Frey, Christian Kuhn
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Despite the identification of numerous molecular pathways modulating cardiac hypertrophy its pathogenesis is not completely understood. In this study we define an unexpected role for Fibin (“fin bud initiation factor homolog”) in cardiomyocyte hy
Externí odkaz:
https://doaj.org/article/6a575afc00444393a65dd76ec25bfb68
Autor:
David Schöler, Sven H. Loosen, Theresa H. Wirtz, Jonathan F. Brozat, Lauredana A. dos Santos Ferreira Grani, Tom Luedde, Lisa Heinrichs, Derk Frank, Alexander Koch, Christoph Roderburg, Martina E. Spehlmann
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundHeart disease is of worldwide importance due to high morbidity and mortality. Extracellular vesicle (EV) concentration and size represent novel diagnostic and prognostic biomarkers, e.g. in patients with liver cancer, but data on their prog
Externí odkaz:
https://doaj.org/article/ec5dfa796e394b7c8468aabcc1833960
Autor:
Georg Lutter, Nina Sophie Pommert, Xiling Zhang, Jette Seiler, Monireh Saeid Nia, David Meier, Stephanie L. Sellers, Stanislav N. Gorb, Jan-Hinnerk Hansen, Hatim Seoudy, Oliver J. Müller, Mohammed Saad, Assad Haneya, Derk Frank, Thomas Puehler, Janarthanan Sathananthan
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17357 (2023)
Transcatheter pulmonary valve replacement is a minimally-invasive alternative treatment for right ventricular outflow tract dysfunction and has been rapidly evolving over the past years. Heart valve prostheses currently available still have major lim
Externí odkaz:
https://doaj.org/article/a2c614988af6405ca54c59ed0027d0bd
Autor:
Hatim Seoudy, Mira vonEberstein, Johanne Frank, Maren Thomann, Thomas Puehler, Georg Lutter, Matthias Lutz, Peter Bramlage, Norbert Frey, Mohammed Saad, Derk Frank
Publikováno v:
ESC Heart Failure, Vol 9, Iss 2, Pp 1071-1079 (2022)
Abstract Aims Many transcatheter aortic valve implantation (TAVI) candidates have underlying heart failure with preserved ejection fraction (HFpEF) in addition to symptomatic aortic stenosis. Diagnosis of HFpEF is challenging. The Heart Failure Assoc
Externí odkaz:
https://doaj.org/article/3a27473b258b4fe9946a56bfbcd50ef7
Publikováno v:
Pathogens, Vol 12, Iss 11, p 1301 (2023)
Cardiac-targeted transgene delivery offers new treatment opportunities for cardiovascular diseases, which massively contribute to global mortality. Restricted gene transfer to cardiac tissue might protect extracardiac organs from potential side-effec
Externí odkaz:
https://doaj.org/article/9e5e6aa8801e4f0e9963dc2c3c60c45f