Výsledky vyhledávání - "Derick H, Lau"

Feasibility and toxicity of concurrent chemoradiation for elderly patients with head and neck cancer

Autor: Derick H Lau, Allen M. Chen, D. Gregory Farwell, Megan E. Daly, Quang Luu, Paul J. Donald

Publikováno v: American Journal of Otolaryngology. 34:631-635

Objectives Although concurrrent chemoradiation is increasingly used for patients with locally advanced head and neck cancer, many elderly patients receive radiation alone due to toxicity concerns. We evaluate acute and late toxicity among patients ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80ff2f1d56510c4ca0db501611257e8
https://doi.org/10.1016/j.amjoto.2013.07.010

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Differential response rates to irradiation among patients with human papillomavirus positive and negative oropharyngeal cancer

Autor: Laurel A. Beckett, D. Gregory Farwell, Andrew T M Vaughan, Allen M. Chen, Regina F Gandour-Edwards, James A. Purdy, Talia Zhara, Judy Li, Derick H Lau

Publikováno v: The Laryngoscope. 123:152-157

Objectives/Hypothesis: To evaluate the responsiveness of human papillomavirus (HPV) -positive and HPV-negative oropharyngeal cancer to intensity-modulated radiotherapy (IMRT), using axial imaging obtained daily during the course of image-guided radio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e344de4a329c297a80709ed909aaa3
https://doi.org/10.1002/lary.23570

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Brachial Plexus-Associated Neuropathy After High-Dose Radiation Therapy for Head-and-Neck Cancer

Autor: Allen M. Chen, William H. Hall, D. Gregory Farwell, Laurel A. Beckett, Judy Li, Derick H Lau, James A. Purdy

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 84:165-169

To identify clinical and treatment-related predictors of brachial plexus-associated neuropathies after radiation therapy for head-and-neck cancer.Three hundred thirty patients who had previously completed radiation therapy for head-and-neck cancer we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50bfde7bc5c457cf4a407a0672571c5d
https://doi.org/10.1016/j.ijrobp.2011.11.019

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Intensity-Modulated Radiotherapy is Associated With Improved Global Quality of Life Among Long-term Survivors of Head-and-Neck Cancer

Autor: Derick H Lau, Quang Luu, D. Gregory Farwell, James A. Purdy, Allen M. Chen, Esther Vazquez

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 84:170-175

To compare the long-term quality of life among patients treated with and without intensity-modulated radiotherapy (IMRT) for head-and-neck cancer.The University of Washington Quality of Life instrument scores were reviewed for 155 patients previously

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f99c32846a8bad5845f7aabe504cf5
https://doi.org/10.1016/j.ijrobp.2011.11.026

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Intercalated Erlotinib-Docetaxel Dosing Schedules Designed to Achieve Pharmacodynamic Separation: Results of a Phase I/II Trial

Autor: Natasha Perkins, Laurel A. Beckett, Primo N. Lara, Paul J. Hesketh, Tianhong Li, Philip C. Mack, Derick H Lau, David R. Gandara, Angela M. Davies, Randeep Sangha

Publikováno v: Journal of Thoracic Oncology. 6(12):2112-2119

Introduction: Epidermal growth factor receptor tyrosine kinase inhibitors given concurrently with chemotherapy do not improve patient outcomes compared with chemotherapy alone in advanced non-small cell lung cancer (NSCLC). On the basis of preclinica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91809eb90f738212eca55e49f77f760e

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Tobacco Smoking During Radiation Therapy for Head-and-Neck Cancer Is Associated With Unfavorable Outcome

Autor: Allen M. Chen, Andrew T M Vaughan, D. Gregory Farwell, Quang Luu, R. Sreeraman, Srinivasan Vijayakumar, Derick H Lau, Leon M. Chen, Kerri Stuart, James A. Purdy

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 79:414-419

Purpose: To evaluate the effect of continued cigarette smoking among patients undergoing radiation therapy for head-and-neck cancer by comparing the clinical outcomes among active smokers and quitters. Methods and Materials: A review of medical recor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65bc60b4b8387e00cece985c220b9861
https://doi.org/10.1016/j.ijrobp.2009.10.050

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Randomized Phase II Trial of Concurrent Versus Sequential Bortezomib Plus Docetaxel in Advanced Non–Small-Cell Lung Cancer: A California Cancer Consortium Trial

Autor: Suresh S. Ramalingam, P. C. Mack, Barbara J. Gitlitz, Frances A. Shepherd, Mariana Koczywas, Jeff Longmate, Derick H Lau, Athanassios Argiris, David R. Gandara, Natasha B. Leighl, Karen L. Reckamp, Primo N. Lara, Chandra P. Belani, John J. Wright

Publikováno v: Clinical Lung Cancer. 12:33-37

Background The proteasome inhibitor bortezomib sensitizes tumor cells to chemotherapy-induced apoptosis. In preclinical non–small-cell lung cancer (NSCLC) models, p53-dependent growth arrest after bortezomib treatment resulted in reduced cytotoxici

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https://doi.org/10.3816/clc.2011.n.004

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Phase II Trial of Irinotecan and Carboplatin for Extensive or Relapsed Small-Cell Lung Cancer

Autor: Derick H Lau, Leonid L. Yavorkovsky, Howard West, David R. Gandara, Minh Huynh, Primo N. Lara, Michael Russin, Desiree S. Goldstein, G. Q. Chen, Lou Fehrenbacher

Publikováno v: Journal of Clinical Oncology. 27:1401-1404

Purpose The regimens of weekly irinotecan with platinum have been used for treatment of metastatic small-cell lung cancer (SCLC). We conducted a multi-institution phase II trial to evaluate a novel 21-day schedule of irinotecan and carboplatin in pat

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https://doi.org/10.1200/jco.2008.20.2127

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A novel small molecule, LAS-0811, inhibits alcohol-induced apoptosis in VL-17A cells

Autor: Senthil K. Venugopal, Derick H Lau, Ming Zhu, Dahn L. Clemens, Tae-Hun Kim, Kit S. Lam, Si Si Wang, Mark A. Zern

Publikováno v: Biochemical and Biophysical Research Communications. 379:876-881

One of the pathways by which alcohol induces hepatocyte apoptosis is via oxidative stress. We screened several chemically-synthesized small molecules and found LAS-0811, which inhibits oxidative stress. In this study, we elucidated its role in inhibi

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https://doi.org/10.1016/j.bbrc.2008.12.133

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LAS0811: From Combinatorial Chemistry to Activation of Antioxidant Response Element

Autor: Aimin Song, Hyounggee Baek, Ming Zhu, Ruiwu Liu, Kit S. Lam, Derick H Lau

Publikováno v: Journal of Biomedicine and Biotechnology, Vol 2009 (2009)
Journal of Biomedicine and Biotechnology

The antioxidant response element (ARE) and its transcription factor, nuclear factor-erythroid 2 p45-related factor 2 (Nrf2), are potential targets for cancer chemoprevention. We sought to screen small molecules synthesized with combinatorial chemistr

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https://doi.org/10.1155/2009/420194

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