Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Deric L. Wheeler"'
Autor:
Tamara Mirzapoiazova, Liz Tseng, Bolot Mambetsariev, Haiqing Li, Chih-Hong Lou, Alex Pozhitkov, Sravani Keerthi Ramisetty, Sangkil Nam, Isa Mambetsariev, Brian Armstrong, Jyoti Malhotra, Leonidas Arvanitis, Mohd Wasim Nasser, Surinder K. Batra, Steven T. Rosen, Deric L. Wheeler, Sharad S. Singhal, Prakash Kulkarni, Ravi Salgia
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110132- (2024)
Summary: Although up to 80% small cell lung cancer (SCLC) patients’ response is good for first-line chemotherapy regimen, most patients develop recurrence of the disease within weeks to months. Here, we report cytostatic effect of leflunomide (Lefl
Externí odkaz:
https://doaj.org/article/c1d2afcf8682490aa1a6bb5963b1e1f1
Autor:
Mari Iida, Bridget E. Crossman, Kourtney L. Kostecki, Christine E. Glitchev, Carlene A. Kranjac, Madisen T. Crow, Jillian M. Adams, Peng Liu, Irene Ong, David T. Yang, Irene Kang, Ravi Salgia, Deric L. Wheeler
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5109 (2024)
Triple-negative breast cancer (TNBC) is characterized by the absence of the estrogen receptor, progesterone receptor, and receptor tyrosine kinase HER2 expression. Due to the limited number of FDA-approved targeted therapies for TNBC, there is an ong
Externí odkaz:
https://doaj.org/article/fca3a4f3de7e457ab929080d8b2d80aa
Autor:
Kourtney L. Kostecki, Mari Iida, Bridget E. Crossman, Ravi Salgia, Paul M. Harari, Justine Y. Bruce, Deric L. Wheeler
Publikováno v:
Cancers, Vol 16, Iss 2, p 312 (2024)
Head and neck cancers (HNCs) arise from the mucosal lining of the aerodigestive tract and are often associated with alcohol use, tobacco use, and/or human papillomavirus (HPV) infection. Over 600,000 new cases of HNC are diagnosed each year, making i
Externí odkaz:
https://doaj.org/article/b7a81501e6b642999a59e9fc27e60c3d
Autor:
Mari Iida, Nellie K. McDaniel, Kourtney L. Kostecki, Noah B. Welke, Carlene A. Kranjac, Peng Liu, Colin Longhurst, Justine Y. Bruce, Seungpyo Hong, Ravi Salgia, Deric L. Wheeler
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background The receptor tyrosine kinase (RTK) epidermal growth factor receptor (EGFR) is overexpressed and an important therapeutic target in Head and Neck cancer (HNC). Cetuximab is currently the only EGFR-targeting agent approved by the FD
Externí odkaz:
https://doaj.org/article/f318e0d14cfd458fb59165e96a799ffd
Autor:
Saumya Srivastava, Ka Ming Pang, Mari Iida, Michael S. Nelson, Jiayi Liu, Arin Nam, Jiale Wang, Isa Mambetsariev, Raju Pillai, Atish Mohanty, Nellie McDaniel, Amita Behal, Prakash Kulkarni, Deric L. Wheeler, Ravi Salgia
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101692- (2020)
Summary: The tyrosine kinase receptor ephrin receptor A2 (EPHA2) is overexpressed in lung (LSCC) and head and neck (HNSCC) squamous cell carcinomas. Although EPHA2 can inhibit tumorigenesis in a ligand-dependent fashion via phosphorylation of Y588 an
Externí odkaz:
https://doaj.org/article/862bc629bc1841d3ab9053896facbb15
Autor:
Aadhya Tiwari, Mari Iida, Corinna Kosnopfel, Mahyar Abbariki, Apostolos Menegakis, Birgit Fehrenbacher, Julia Maier, Martin Schaller, Sara Y. Brucker, Deric L. Wheeler, Paul M. Harari, Ulrich Rothbauer, Birgit Schittek, Daniel Zips, Mahmoud Toulany
Publikováno v:
Cancers, Vol 12, Iss 10, p 2795 (2020)
The multifunctional protein Y-box binding protein-1 (YB-1) regulates all the so far described cancer hallmarks including cell proliferation and survival. The MAPK/ERK and PI3K/Akt pathways are also the major pathways involved in cell growth, prolifer
Externí odkaz:
https://doaj.org/article/145fc2c3ce1d4a3a9bf0b533a10575f9
Autor:
Paul A. Clark, Mari Iida, Daniel M. Treisman, Haviryaji Kalluri, Sathyapriya Ezhilan, Michael Zorniak, Deric L. Wheeler, John S. Kuo
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 5, Pp 420-428 (2012)
Epidermal growth factor receptor (EGFR) signaling is strongly implicated in glioblastoma (GBM) tumorigenesis. However, molecular agents targeting EGFR have demonstrated minimal efficacy in clinical trials, suggesting the existence of GBM resistance m
Externí odkaz:
https://doaj.org/article/532e2b057b8e4ce59b1099ff33e191ea
Publikováno v:
Journal of Skin Cancer, Vol 2013 (2013)
Externí odkaz:
https://doaj.org/article/f47f0e5284d043619b05e191b2a88ecc
Autor:
Kourtney L. Kostecki, Mari Iida, Anne L. Wiley, Stanley Kimani, Bridget Mehall, Kaitlin Tetreault, Roxana Alexandridis, Menggang Yu, Seungpyo Hong, Ravi Salgia, Justine Y. Bruce, Raymond B. Birge, Paul M. Harari, Deric L. Wheeler
Publikováno v:
Head & Neck. 45:1255-1271
Autor:
Mahmoud Toulany, Mari Iida, Konstanze Lettau, John P. Coan, Simone Rebholz, Shayan Khozooei, Paul M. Harari, Deric L. Wheeler
Publikováno v:
Radiotherapy and Oncology. 174:92-100
AKT1 must be present and activated in the nucleus immediately after irradiation to stimulate AKT1-dependent double-strand breaks (DSB) repair through the fast non-homologous end-joining (NHEJ) repair process. We investigated the subcellular distribut