Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non-Small Cell Lung Cancer.

Autor: Skwarski M; Department of Oncology, University of Oxford, Oxford, England, United Kingdom.; Department of Oncology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., McGowan DR; Department of Oncology, University of Oxford, Oxford, England, United Kingdom.; Radiation Physics and Protection, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., Belcher E; Department of Cardiothoracic Surgery, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., Di Chiara F; Department of Cardiothoracic Surgery, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., Stavroulias D; Department of Cardiothoracic Surgery, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., McCole M; Department of Cellular Pathology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., Derham JL; Department of Oncology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., Chu KY; Department of Oncology, University of Oxford, Oxford, England, United Kingdom.; Department of Oncology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., Teoh E; Department of Oncology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., Chauhan J; Ludwig Institute for Cancer Research Oxford, University of Oxford, Oxford, England, United Kingdom., O'Reilly D; Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Harris BHL; Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Macklin PS; Nuffield Department of Medicine, University of Oxford, Oxford, England, United Kingdom., Bull JA; Wolfson Centre for Mathematical Biology, University of Oxford, Oxford, England, United Kingdom., Green M; Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Rodriguez-Berriguete G; Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Prevo R; Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Folkes LK; Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Campo L; Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Ferencz P; Institute of Biomedical Engineering, University of Oxford, Oxford, England, United Kingdom., Croal PL; Institute of Biomedical Engineering, University of Oxford, Oxford, England, United Kingdom., Flight H; Oncology Clinical Trials Office, Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Qi C; Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom., Holmes J; Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom., O'Connor JPB; Division of Cancer Sciences, University of Manchester, Manchester, England, United Kingdom., Gleeson FV; Department of Radiology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., McKenna WG; Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Harris AL; Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Bulte D; Institute of Biomedical Engineering, University of Oxford, Oxford, England, United Kingdom., Buffa FM; Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Macpherson RE; Department of Radiology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., Higgins GS; Department of Oncology, University of Oxford, Oxford, England, United Kingdom. geoffrey.higgins@oncology.ox.ac.uk.; Department of Oncology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 May 01; Vol. 27 (9), pp. 2459-2469. Date of Electronic Publication: 2021 Feb 17.