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pro vyhledávání: '"Derek Yurgaitis"'
Autor:
Andrew J. Staab, Derek Yurgaitis, Kahnie Pham-Kaplita, Shirley J. Lasch, Pamela A. Trail, Dalton King, Raymond A. Firestone
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(13)
The 6-maleimidocaproylhydrazone derivatives of highly potent antitumor agents 5-Diacetoxypentyldoxorubicin and Morpholinodoxorubicin were synthesized and conjugated to monoclonal antibody BR96 and control IgG. Immunoconjugate molar ratios were genera