Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Derek W. Trobaugh"'
Autor:
Christina L. Gardner, Chengqun Sun, Matthew D. Dunn, Theron C. Gilliland, Derek W. Trobaugh, Yutaka Terada, Douglas S. Reed, Amy L. Hartman, William B. Klimstra
Publikováno v:
Viruses, Vol 15, Iss 1, p 5 (2022)
The Department of Defense recently began an effort to improve and standardize virus challenge materials and efficacy determination strategies for testing therapeutics and vaccines. This includes stabilization of virus genome sequences in cDNA form wh
Externí odkaz:
https://doaj.org/article/39c888d0ed164b2b9f0bb2f6ad98b4ae
Autor:
Derek W Trobaugh, Chengqun Sun, Nishank Bhalla, Christina L Gardner, Matthew D Dunn, William B Klimstra
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1007867 (2019)
Eastern equine encephalitis virus (EEEV), a mosquito-borne RNA virus, is one of the most acutely virulent viruses endemic to the Americas, causing between 30% and 70% mortality in symptomatic human cases. A major factor in the virulence of EEEV is th
Externí odkaz:
https://doaj.org/article/d8899a9e015846fa931e6b83ecce4270
Publikováno v:
PLoS Pathogens, Vol 15, Iss 2, p e1007584 (2019)
Live attenuated vaccines (LAVs), if sufficiently safe, provide the most potent and durable anti-pathogen responses in vaccinees with single immunizations commonly yielding lifelong immunity. Historically, viral LAVs were derived by blind passage of v
Externí odkaz:
https://doaj.org/article/15628936e157463298e6f016f2dff81e
Autor:
Christopher M. Weiss, Derek W. Trobaugh, Chengqun Sun, Tiffany M. Lucas, Michael S. Diamond, Kate D. Ryman, William B. Klimstra
Publikováno v:
mSphere, Vol 3, Iss 5 (2018)
ABSTRACT Type I interferon (IFN)-stimulated genes (ISGs) have critical roles in inhibiting virus replication and dissemination. Despite advances in understanding the molecular basis of ISG restriction, the antiviral mechanisms of many remain unclear.
Externí odkaz:
https://doaj.org/article/a2287e9b9d7344b2a42e47c800dea8d0
Autor:
Arthur S. Kim, S. Kyle Austin, Derek W. Trobaugh, Mark K. Slifka, Lauren E. Williamson, Daved H. Fremont, Michael S. Diamond, Adam Zuiani, Douglas S. Reed, Chengqun Sun, Christina L. Gardner, James E. Crowe, William B. Klimstra, Katherine Basore
Publikováno v:
Nature microbiology
Eastern equine encephalitis virus (EEEV) is a mosquito-transmitted alphavirus with a high case mortality rate in humans. EEEV is a biodefence concern because of its potential for aerosol spread and the lack of existing countermeasures. Here, we ident
Autor:
William B. Klimstra, Derek W. Trobaugh
Publikováno v:
Current Opinion in Virology. 23:30-34
Alphaviruses are medically important mosquito-borne viruses that cause a range of diseases in humans from febrile illness to arthritis or encephalitis. The innate immune response functions to suppress virus replication through upregulation of antivir
Autor:
Christina L. Gardner, Chengqun Sun, Derek W. Trobaugh, Nishank Bhalla, William B. Klimstra, Matthew D. Dunn
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1007867 (2019)
PLoS Pathogens
PLoS Pathogens
Eastern equine encephalitis virus (EEEV), a mosquito-borne RNA virus, is one of the most acutely virulent viruses endemic to the Americas, causing between 30% and 70% mortality in symptomatic human cases. A major factor in the virulence of EEEV is th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa639a06b4e6514baaf86a77a90cec2
Autor:
Kate D. Ryman, William B. Klimstra, Derek W. Trobaugh, Michael S. Diamond, Chengqun Sun, Christopher Weiss, Tiffany M. Lucas
Publikováno v:
mSphere, Vol 3, Iss 5 (2018)
mSphere, Vol 3, Iss 5, p e00209-18 (2018)
mSphere, Vol 3, Iss 5, p e00209-18 (2018)
Type I interferon (IFN)-stimulated genes (ISGs) have critical roles in inhibiting virus replication and dissemination. Despite advances in understanding the molecular basis of ISG restriction, the antiviral mechanisms of many remain unclear. The 20-k
Autor:
Gai Liu, Marco Tonelli, Cheng Huang, Michael S. Diamond, William B. Klimstra, Derek W. Trobaugh, Gaya K. Amarasinghe, James P. White, Slobodan Paessler, Christina L. Gardner, Kiyoshi Takeda, Jennifer L. Hyde, Taishi Kimura
Publikováno v:
Science. 343:783-787
Although interferon (IFN) signaling induces genes that limit viral infection, many pathogenic viruses overcome this host response. As an example, 2'-O methylation of the 5' cap of viral RNA subverts mammalian antiviral responses by evading restrictio
Autor:
Elik Chapnik, Eryu Wang, Kate D. Ryman, Derek W. Trobaugh, Christina L. Gardner, William B. Klimstra, Andrew D. Haddow, Scott C. Weaver, Chengqun Sun, Alexander Mildner
Publikováno v:
Nature
Currently, there is little evidence for a notable role of the vertebrate microRNA (miRNA) system in the pathogenesis of RNA viruses. This is primarily attributed to the ease with which these viruses mutate to disrupt recognition and growth suppressio