Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Derek W. R. Gray"'
Autor:
Raina D. Ramnath Ph.D., Elisa Maillard, Katherine Jones, Paul A. Bateman, Stephen S. J. Hughes, Jane Gralla, Paul R. Johnson, Derek W. R. Gray D. Phil (Oxon), F.R.C.S., M.R.C.P.
Publikováno v:
Cell Transplantation, Vol 24 (2015)
Culture of human pancreatic islets is now routinely carried out prior to clinical islet allotransplantation, using conditions that have been developed empirically. One of the major causes of early islet destruction after transplantation is the proces
Externí odkaz:
https://doaj.org/article/16a8767a57b743918444fee4b8f80a5f
Publikováno v:
Cell Transplantation, Vol 21 (2012)
Optimal human islet isolation requires the delivery of bacterial collagenase to the pancreatic islet–exocrine interface. However, we have previously demonstrated the presence of collagenase within human islets immediately following intraductal coll
Externí odkaz:
https://doaj.org/article/892f9d64c95d4bb984a24473c6350941
Autor:
Derek W. R. Gray, R Ramnath, Katherine Elizabeth Jones, P A Bateman, Paul Johnson, Jane Gralla, Elisa Maillard, Stephen J. Hughes
Publikováno v:
Cell Transplantation, Vol 24 (2015)
Culture of human pancreatic islets is now routinely carried out prior to clinical islet allotransplantation, using conditions that have been developed empirically. One of the major causes of early islet destruction after transplantation is the proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd6b11dff67323d0bf0406747cdae99
https://doi.org/10.3727/096368914x685320
https://doi.org/10.3727/096368914x685320
Autor:
Derek W. R. Gray, Kathryn J. Wood, Paul Johnson, Piotr Trzonkowski, Satish N. Nadig, Stephen J. Hughes, W Zhang, Douglas C. Wu, Joanna Hester
Publikováno v:
Transplantation
Background Human regulatory T cells (Treg) offer an attractive adjunctive therapy to reduce current reliance on lifelong, nonspecific immunosuppression after transplantation. Here, we evaluated the ability of ex vivo expanded human Treg to prevent th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce668769fb4857e6609317bba8e4d8f3
https://doi.org/10.1097/tp.0b013e31829fa271
https://doi.org/10.1097/tp.0b013e31829fa271
The ATP- and sulphonylurea-sensitivity of the ATP-sensitive K-channel was measured in human pancreatic B cells. In inside-out patches, half-maximal inhibition of channel activity was produced by 10 mumol/l ATP (with 2 mM Mg2+) and ATP-inhibition was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367060450b7c0f498de24e4b18328da0
https://ora.ox.ac.uk/objects/uuid:4024758f-a903-462c-83eb-6fd8189f4563
https://ora.ox.ac.uk/objects/uuid:4024758f-a903-462c-83eb-6fd8189f4563
Autor:
Derek W. R. Gray
Publikováno v:
The Open Transplantation Journal. 2:40-53
Complex areas of scientific endeavor may sometimes benefit from a theoretical and/or reductionist approach to guide the direction of future experiments, perhaps best illustrated by the field of cosmology. The field of immunology in general, and trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15d2ca591b59c96296233776b3fdba7b
https://doi.org/10.2174/1874418400802010040
https://doi.org/10.2174/1874418400802010040
Autor:
Li-Way Chang, Ashok Handa, Amit Agarwal, Derek W. R. Gray, Paul L. F. Giangrande, Peter J. Horton, P. McShane, Lionel Badet, Thomas T. Titus
Publikováno v:
Transplantation. 75:1317-1322
Background. A report of inflammatory damage when islets come into contact with allogeneic blood prompted us to confirm the finding.Methods. Fresh handpicked human islets were incubated in blood group matched, nonsensitized allogeneic blood. Destructi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1652982d7aabe872f1fa71b18c3f2a52
https://doi.org/10.1097/01.tp.0000064517.98252.00
https://doi.org/10.1097/01.tp.0000064517.98252.00
Autor:
Eric Metzen, Ashok Handa, Derek W. R. Gray, Lionel Badet, Paul L. F. Giangrande, P. McShane, Li-Way Chang, Thomas T. Titus
Publikováno v:
Xenotransplantation. 9:91-96
Background: Mouse islets transplanted under the renal subcapsular space of cynomolgus monkeys are subject to a form of hyperacute rejection, the mechanism of which is unclear. As islets are in contact with whole blood at the time of transplantation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8deff59a09a97106585ff56ad977d004
https://doi.org/10.1034/j.1399-3089.2002.1o040.x
https://doi.org/10.1034/j.1399-3089.2002.1o040.x
Autor:
Li-Way Chang, Zhenshun Song, Lionel Badet, P. McShane, Thomas T. Titus, David J. P. Ferguson, Derek W. R. Gray
Publikováno v:
Transplantation. 72:1867-1874
Background. Islets transplanted from other species to man has the potential to cure diabetes but whether islets are subject to hyperacute rejection after xenotransplantation is contentious. We transplanted mouse pancreatic islets of mouse beneath the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65d677bc78d1c348114951becf878060
https://doi.org/10.1097/00007890-200112270-00002
https://doi.org/10.1097/00007890-200112270-00002
Publikováno v:
Annals of Surgery. 232:98-103
Renal transplantation is the optimal mode of replacement therapy in most patients with end-stage renal disease. There has been progressive improvement in short-term patient and graft survival rates in the “cyclosporine era.” However, in the longe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1b577accd735714d4a2da6e8761954
https://doi.org/10.1097/00000658-200007000-00014
https://doi.org/10.1097/00000658-200007000-00014