Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Derek T. O’hagan"'
Autor:
Ugo D’Oro, Derek T. O’Hagan
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-8 (2024)
Abstract A decade ago, we described a new approach to discover next generation adjuvants, identifying small-molecule immune potentiators (SMIPs) as Toll-like receptor (TLR)7 agonists. We also optimally formulated these drugs through adsorption to alu
Externí odkaz:
https://doaj.org/article/6f6e681dbd2e486190956a35ac5082d0
Autor:
Lilit Grigoryan, Audrey Lee, Alexandra C. Walls, Lilin Lai, Benjamin Franco, Prabhu S. Arunachalam, Yupeng Feng, Wei Luo, Abigail Vanderheiden, Katharine Floyd, Samuel Wrenn, Deleah Pettie, Marcos C. Miranda, Elizabeth Kepl, Rashmi Ravichandran, Claire Sydeman, Natalie Brunette, Michael Murphy, Brooke Fiala, Lauren Carter, Robert L. Coffman, David Novack, Harry Kleanthous, Derek T. O’Hagan, Robbert van der Most, Jason S. McLellan, Mehul Suthar, David Veesler, Neil P. King, Bali Pulendran
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-14 (2022)
Abstract Adjuvants enhance the magnitude and the durability of the immune response to vaccines. However, there is a paucity of comparative studies on the nature of the immune responses stimulated by leading adjuvant candidates. In this study, we comp
Externí odkaz:
https://doaj.org/article/2196e1d269574af6a71cb396be3fe2ca
Autor:
Saaussan Madi, Fang Xie, Kamyar Farhangi, Chih-Yang Hsu, Shih-Hsun Cheng, Tolulope Aweda, Bhasker Radaram, Stephanie Slania, Tammy Lambert, Mary Rambo, Tina Skedzielewski, Austin Cole, Valeriia Sherina, Shannon McKearnan, Hoang Tran, Hasan Alsaid, Minh Doan, Alan H. Stokes, Derek T. O’Hagan, Giulietta Maruggi, Sylvie Bertholet, Stéphane T. Temmerman, Russell Johnson, Beat M. Jucker
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
The goal of this study was to utilize a multimodal magnetic resonance imaging (MRI) and positron emission tomography (PET) imaging approach to assess the local innate immune response in skeletal muscle and draining lymph node following vaccination in
Externí odkaz:
https://doaj.org/article/f8cb07fbb3844bfdbcb71445fb51ca9e
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-15 (2021)
Abstract Emulsion adjuvants such as MF59 and AS03 have been used for more than two decades as key components of licensed vaccines, with over 100 million doses administered to diverse populations in more than 30 countries. Substantial clinical experie
Externí odkaz:
https://doaj.org/article/75d1380960444ee990bb5e69e49dc32a
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1884 (2023)
Aluminum-based adjuvants will continue to be a key component of currently approved and next generation vaccines, including important combination vaccines. The widespread use of aluminum adjuvants is due to their excellent safety profile, which has be
Externí odkaz:
https://doaj.org/article/1cd8db26f020430783dacf6cd2962fbd
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/e5f8067830144b07ac2835d863125981
Autor:
Rushit N. Lodaya, Amey P. Kanitkar, Asma Ashraf, Douty Bamba, Mansoor M. Amiji, Derek T. O’Hagan
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 238 (2023)
The development of new vaccine adjuvants represents a key approach to improvingi the immune responses to recombinant vaccine antigens. Emulsion adjuvants, such as AS03 and MF59, in combination with influenza vaccines, have allowed antigen dose sparin
Externí odkaz:
https://doaj.org/article/c0bf05fd78584559baf39398c77b6cd2
Autor:
Donatello Laera, Camilla Scarpellini, Simona Tavarini, Barbara Baudner, Agnese Marcelli, Carlo Pergola, Malte Meppen, Derek T. O’Hagan
Publikováno v:
Vaccines, Vol 11, Iss 1, p 155 (2023)
Although aluminium-based vaccines have been used for almost over a century, their mechanism of action remains unclear. It is established that antigen adsorption to the adjuvant facilitates delivery of the antigen to immune cells at the injection site
Externí odkaz:
https://doaj.org/article/bde4b3d88f134f58a8bbf43e489a53f6
Autor:
Despo Chatzikleanthous, Robert Cunliffe, Filippo Carboni, Maria Rosaria Romano, Derek T. O'Hagan, Craig W. Roberts, Yvonne Perrie, Roberto Adamo
Publikováno v:
MethodsX, Vol 7, Iss , Pp 100942- (2020)
The well-known Toll like receptor 9 (TLR9) agonist CpG ODN has shown promising results as vaccine adjuvant in preclinical and clinical studies, however its in vivo stability and potential systemic toxicity remain a concern. In an effort to overcome t
Externí odkaz:
https://doaj.org/article/477d9d311e264ae7969c12e06318030c
Autor:
Joseph R. Francica, Daniel E. Zak, Caitlyn Linde, Emilio Siena, Carrie Johnson, Michal Juraska, Nicole L. Yates, Bronwyn Gunn, Ennio De Gregorio, Barbara J. Flynn, Nicholas M. Valiante, Padma Malyala, Susan W. Barnett, Pampi Sarkar, Manmohan Singh, Siddhartha Jain, Margaret Ackerman, Munir Alam, Guido Ferrari, Andres Salazar, Georgia D. Tomaras, Derek T. O'Hagan, Alan Aderem, Galit Alter, Robert A. Seder
Publikováno v:
Blood Advances, Vol 1, Iss 25, Pp 2329-2342 (2017)
Abstract: Adjuvants have a critical role for improving vaccine efficacy against many pathogens, including HIV. Here, using transcriptional RNA profiling and systems serology, we assessed how distinct innate pathways altered HIV-specific antibody resp
Externí odkaz:
https://doaj.org/article/412a4dcf39fe46fa94a258dc035552c8