Adjuvanting a subunit SARS-CoV-2 nanoparticle vaccine to induce protective immunity in non-human primates

Autor: Bali Pulendran, David Novack, Deleah Pettie, Jay Rappaport, Xiaoying Shen, Ching-Lin Hsieh, Rudolph B Bohm, Alexandra C. Walls, Elizabeth Kepl, David Veesler, Shankar Subramaniam, Rino Rappuoli, Harry Kleanthous, Claire Sydeman, Derek T O Hagan, Alex Lee Zhu, JoAnne L. Flynn, Robbert van der Most, Christopher Monjure, Kenneth S. Plante, Francois Villinger, Prabhu S. Arunachalam, Nicholas J. Maness, Pyone P. Aye, Sally Shin, Matthew J. Gorman, Natalie Brunette, Michael E. P. Murphy, Lilin Lai, Scott D. Boyd, Caroline Atyeo, Katharina Röltgen, Venkata Viswanadh Edara, Robert L Coffman, Chad J. Roy, Kasi E. Russell-Lodrigue, David C. Montefiori, Nadia A. Golden, Meera Trisal, Jessica A. Plante, John C. Kraft, Mehul S. Suthar, Jason Dufour, Kenneth A. Rogers, Marcos C. Miranda, Lisa Shirreff, Brooke Fiala, Samuel Wrenn, Lara Doyle-Meyer, Shakti Gupta, Douglas E. Ferrell, Jane Fontenot, Jason S. McLellan, Lauren Carter, Mary Jane Navarro, Alexander G. White, Stephanie Fischinger, Neil P. King, Galit Alter, Chunfeng Li

Publikováno v: bioRxiv : the preprint server for biology.

The development of a portfolio of SARS-CoV-2 vaccines to vaccinate the global population remains an urgent public health imperative. Here, we demonstrate the capacity of a subunit vaccine under clinical development, comprising the SARS-CoV-2 Spike pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d21f226ab76efebd2264b0b460ab88
https://pubmed.ncbi.nlm.nih.gov/33873199

Poly(Lactide-Coglycolide) Microparticles As Vaccine Adjuvants

Autor: Derek T. O’ Hagan, Manmohan Singh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0375f501a72422fb5d6cde487e2a79f4
https://doi.org/10.1385/1-59259-083-7:91

Microreview Innate immunity and biodefence vaccines.

Autor: Valiante, Nicholas M.¹, O'Hagan, Derek T.¹, Ulmer, Jeffery B.¹ jeffrey_ulmer@chiron.com

Publikováno v: Cellular Microbiology. Nov2003, Vol. 5 Issue 11, p755. 6p.

Systems analysis of human responses to an aluminium hydroxide-adsorbed TLR7 agonist (AS37) adjuvanted vaccine reveals a dose-dependent and specific activation of the interferon-mediated antiviral response.

Autor: Siena E; GSK, Via Fiorentina 1, 53100 Siena, Italy. Electronic address: emilio.x.siena@gsk.com., Schiavetti F; GSK, Via Fiorentina 1, 53100 Siena, Italy. Electronic address: francesca.x.schiavetti@gsk.com., Borgogni E; GSK, Via Fiorentina 1, 53100 Siena, Italy. Electronic address: erica.x.borgogni@gsk.com., Taccone M; GSK, Via Fiorentina 1, 53100 Siena, Italy. Electronic address: marianna.x.taccone@gsk.com., Faenzi E; GSK, Via Fiorentina 1, 53100 Siena, Italy. Electronic address: elisa.x.faenzi@gsk.com., Brazzoli M; GSK, Via Fiorentina 1, 53100 Siena, Italy. Electronic address: michela.x.brazzoli@gsk.com., Aprea S; GSK, Via Fiorentina 1, 53100 Siena, Italy. Electronic address: susanna.x.aprea@gsk.com., Bardelli M; GSK, Via Fiorentina 1, 53100 Siena, Italy. Electronic address: monia.x.bardelli@gsk.com., Volpini G; GSK, Via Fiorentina 1, 53100 Siena, Italy. Electronic address: gifox1960@yahoo.it., Buricchi F; GSK, Via Fiorentina 1, 53100 Siena, Italy. Electronic address: francesca.x.buricchi@gsk.com., Sammicheli C; GSK, Via Fiorentina 1, 53100 Siena, Italy. Electronic address: chiara.x.sammicheli@gsk.com., Tavarini S; GSK, Via Fiorentina 1, 53100 Siena, Italy. Electronic address: simona.x.tavarini@gsk.com., Bechtold V; GSK, Rue de l'Institut 89, 1330 Rixensart, Belgium. Electronic address: viviane.x.bechtold@gsk.com., Blohmke CJ; GSK, Via Fiorentina 1, 53100 Siena, Italy. Electronic address: christoph.j.blohmke@gsk.com., Cardamone D; Toscana Life Sciences Foundation, Siena, Italy. Electronic address: d.cardamone@toscanalifesciences.org., De Intinis C; GSK, Via Fiorentina 1, 53100 Siena, Italy; University of Turin, Via Verdi 8, 10124 Torino, Italy. Electronic address: carlo.deintinis@gmail.com., Gonzalez-Lopez A; GSK, 14200 Shady Grove Rd, Rockville MD, USA. Electronic address: antoniogonzalezlopez17@gmail.com., O'Hagan DT; University of Turin, Via Verdi 8, 10124 Torino, Italy. Electronic address: hagan@gsk.com., Nuti S; GSK, 14200 Shady Grove Rd, Rockville MD, USA. Electronic address: sandra.x.nuti@gsk.com., Seidl C; GSK, 14200 Shady Grove Rd, Rockville MD, USA. Electronic address: claudia.x.seidl@gsk.com., Didierlaurent AM; GSK, Rue de l'Institut 89, 1330 Rixensart, Belgium. Electronic address: arnaud.didierlaurent@unige.ch., Bertholet S; GSK, 14200 Shady Grove Rd, Rockville MD, USA. Electronic address: sylvie.c.bertholet-girardin@gsk.com., D'Oro U; GSK, Via Fiorentina 1, 53100 Siena, Italy. Electronic address: ugo.x.doro@gsk.com., Medini D; Toscana Life Sciences Foundation, Siena, Italy. Electronic address: d.medini@toscanalifesciences.org., Finco O; GSK, Via Fiorentina 1, 53100 Siena, Italy. Electronic address: oretta.x.finco@gsk.com.

Publikováno v: Vaccine [Vaccine] 2023 Jan 16; Vol. 41 (3), pp. 724-734. Date of Electronic Publication: 2022 Dec 21.