Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Derek T, Logan"'
Autor:
Ornella Bimai, Ipsita Banerjee, Inna Rozman Grinberg, Ping Huang, Lucas Hultgren, Simon Ekström, Daniel Lundin, Britt-Marie Sjöberg, Derek T Logan
Publikováno v:
eLife, Vol 12 (2024)
A small, nucleotide-binding domain, the ATP-cone, is found at the N-terminus of most ribonucleotide reductase (RNR) catalytic subunits. By binding adenosine triphosphate (ATP) or deoxyadenosine triphosphate (dATP) it regulates the enzyme activity of
Externí odkaz:
https://doaj.org/article/58c8ed64ca754d1ea6c8072d269703e7
Autor:
Maria Luisa Verteramo, Majda Misini Ignjatović, Rohit Kumar, Sven Wernersson, Vilhelm Ekberg, Johan Wallerstein, Göran Carlström, Veronika Chadimová, Hakon Leffler, Fredrik Zetterberg, Derek T. Logan, Ulf Ryde, Mikael Akke, Ulf J. Nilsson
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109636- (2024)
Summary: Halogen bonding is increasingly utilized in efforts to achieve high affinity and selectivity of molecules designed to bind proteins, making it paramount to understand the relationship between structure, dynamics, and thermodynamic driving fo
Externí odkaz:
https://doaj.org/article/04a7dad9b6fc435daabaaf102e239b88
Autor:
Inna Rozman Grinberg, Markel Martínez-Carranza, Ornella Bimai, Ghada Nouaïria, Saher Shahid, Daniel Lundin, Derek T. Logan, Britt-Marie Sjöberg, Pål Stenmark
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Ribonucleotide reductase (RNR) is an essential enzyme that catalyzes the synthesis of DNA building blocks. Here, the authors present the cryo-EM structure and mechanism of action of NrdR, the RNR-specific repressor, that controls transcription of RNR
Externí odkaz:
https://doaj.org/article/c11cf65babe14228a3e8ad1e379ec405
Autor:
Mark F. Maurer, Katherine E. Lewis, Joseph L. Kuijper, Dan Ardourel, Chelsea J. Gudgeon, Siddarth Chandrasekaran, Sherri L. Mudri, Kayla N. Kleist, Chris Navas, Martin F. Wolfson, Mark W. Rixon, Ryan Swanson, Stacey R. Dillon, Steven D. Levin, Yengo Raymond Kimbung, Masato Akutsu, Derek T. Logan, Björn Walse, Kristine M. Swiderek, Stanford L. Peng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
CD28 costimulatory signalling can be suppressed by immune checkpoints, such as CTLA-4 and PD-1. Here the authors describe the design of the fusion therapeutic davoceticept (ALPN-202), based on a variant CD80 extracellular domain engineered to bind PD
Externí odkaz:
https://doaj.org/article/1c1e0e459c4147429eef80ef95841f04
Autor:
Johan Wallerstein, Vilhelm Ekberg, Majda Misini Ignjatović, Rohit Kumar, Octav Caldararu, Kristoffer Peterson, Sven Wernersson, Ulrika Brath, Hakon Leffler, Esko Oksanen, Derek T. Logan, Ulf J. Nilsson, Ulf Ryde, Mikael Akke
Publikováno v:
JACS Au, Vol 1, Iss 4, Pp 484-500 (2021)
Externí odkaz:
https://doaj.org/article/2981db6db17549c9b3a2c12397786a4f
Autor:
Roland Beckmann, Kristian Jensen, Sebastian Fenn, Janina Speck, Katrin Krause, Anastasia Meier, Melanie Röth, Sascha Fauser, Raymond Kimbung, Derek T. Logan, Martin Steegmaier, Hubert Kettenberger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Bispecific antibodies can bind to two distinct targets though the fusion of two different Fv regions. In this study, the authors develop DutaFabs that present two separated and independent antigen binding sites within the same Fv region, giving rise
Externí odkaz:
https://doaj.org/article/70c0f8f5eaae4c48be3ad457ee0a7a4b
Autor:
Erich J. Goebel, Chandramohan Kattamuri, Gregory R. Gipson, Lavanya Krishnan, Moises Chavez, Magdalena Czepnik, Michelle C. Maguire, Rosa Grenha, Maria Håkansson, Derek T. Logan, Asya V. Grinberg, Dianne Sako, Roselyne Castonguay, Ravindra Kumar, Thomas B. Thompson
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103590- (2022)
Summary: The 30+ unique ligands of the TGFβ family signal by forming complexes using different combinations of type I and type II receptors. Therapeutically, the extracellular domain of a single receptor fused to an Fc molecule can effectively neutr
Externí odkaz:
https://doaj.org/article/0b41a10071f446298a7ec2b0eff0ed7a
Autor:
Thierry Franza, Annika Rogstam, Saravanamuthu Thiyagarajan, Matthew J Sullivan, Aurelie Derré-Bobillot, Mikael C Bauer, Kelvin G K Goh, Violette Da Cunha, Philippe Glaser, Derek T Logan, Glen C Ulett, Claes von Wachenfeldt, Philippe Gaudu
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009791 (2021)
In many Gram-positive bacteria, the redox-sensing transcriptional repressor Rex controls central carbon and energy metabolism by sensing the intra cellular balance between the reduced and oxidized forms of nicotinamide adenine dinucleotide; the NADH/
Externí odkaz:
https://doaj.org/article/3ee0357565124674bb62d93dadb56787
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The essential enzyme ribonucleotide reductase (RNR) is highly regulated both at the level of overall activity and substrate specificity. Studies of class I, aerobic RNRs have shown that overall activity is downregulated by the binding of dATP to a sm
Externí odkaz:
https://doaj.org/article/de0fb2415a274c318ff68f735ff3b807
Autor:
Jonas A. Nilsson, Björn Walse, Derek T. Logan, Joydeep Bhadury, Martin Welin, Dağsu Demir, Somsundar Veppil Muralidharan, Lydia C. Green, Lisa M. Nilsson
Microarray data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e34f9fc62dbc367105df1b7c8b6324
https://doi.org/10.1158/0008-5472.22409249.v1
https://doi.org/10.1158/0008-5472.22409249.v1
