Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Derek Sim"'
Autor:
Xiao-Yan Zhao, Andreas Wilmen, Dongli Wang, Xinquan Wang, Maxine Bauzon, Ji-Yun Kim, Lars Linden, Liang Li, Ursula Egner, Tobias Marquardt, Dieter Moosmayer, Jan Tebbe, Julian Marius Glück, Philipp Ellinger, Kirk McLean, Shujun Yuan, Subramanian Yegneswaran, Xiaoqiao Jiang, Vince Evans, Jian-Ming Gu, Doug Schneider, Ying Zhu, Yifan Xu, Cornell Mallari, Ashley Hesslein, Yan Wang, Nicole Schmidt, Katrin Gutberlet, Christine Ruehl-Fehlert, Alexius Freyberger, Terry Hermiston, Chandra Patel, Derek Sim, Laurent O. Mosnier, Volker Laux
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Activated protein C (APC) is a plasma serine protease with antithrombotic and cytoprotective functions. Here, the authors develop a monoclonal antibody that specifically inhibits APC’s anticoagulant function without compromising its cytoprotective
Externí odkaz:
https://doaj.org/article/9ba7c3d64bcb4b03984dbf3b38cd94db
Autor:
Victoria C Barclay, Derek Sim, Brian H K Chan, Lucas A Nell, Maia A Rabaa, Andrew S Bell, Robin F Anders, Andrew F Read
Publikováno v:
PLoS Biology, Vol 10, Iss 7, p e1001368 (2012)
Malaria vaccine developers are concerned that antigenic escape will erode vaccine efficacy. Evolutionary theorists have raised the possibility that some types of vaccine could also create conditions favoring the evolution of more virulent pathogens.
Externí odkaz:
https://doaj.org/article/226e263b1947497aa18f70475a6dfc8a
Publikováno v:
Journal of virology. 96(20)
To characterize the ongoing evolution of myxoma virus in Australian rabbits we used experimental infections of laboratory rabbits to determine the virulence and disease phenotypes of recent virus isolates. The viruses, collected between 2012-2015, fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a07e1777aacca75132dd0a0b0253213
https://pubmed.ncbi.nlm.nih.gov/36197107
https://pubmed.ncbi.nlm.nih.gov/36197107
Publikováno v:
Evolution, Medicine, and Public Health
Background and objectives There is a significant interest in identifying clinically effective drug treatment regimens that minimize the de novo evolution of antimicrobial resistance in pathogen populations. However, in vivo studies that vary treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4dd5cad5cb975efdf7f9d9cde0c5458f
https://pubmed.ncbi.nlm.nih.gov/33209305
https://pubmed.ncbi.nlm.nih.gov/33209305
Publikováno v:
In Microelectronics Reliability 2005 45(9):1449-1454
Autor:
Sofia Kosolapova, Derek Sim, Chandrasekaran Nagaswami, Katalin Kauser, Adam Cuker, Lilley Leong, Zelda de Lange, Yifan Xu, John W. Weisel, Irina N. Chernysh
Publikováno v:
Research and Practice in Thrombosis and Haemostasis
Essentials Factor VIII (FVIII) replacement in hemophilia A corrects bleeding due to low thrombin generation. There is uncertainty about the minimal or trough level of FVIII needed for optimal treatment. FVIII improves physical properties of hemophili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f623de3bead8fd338559f111469264f4
https://pubmed.ncbi.nlm.nih.gov/29713693
https://pubmed.ncbi.nlm.nih.gov/29713693
Publikováno v:
ACS Catalysis. 5:3609-3612
An efficient and enantioselective α-hydroxylation of acyclic as well as cyclic ketones using molecular oxygen has been developed. This simple catalytic procedure uses a readily available phase-transfer catalyst and produces a wide range of valuable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e67b1300965d48489586aeaeb9dc7b72
https://doi.org/10.1021/acscatal.5b00583
https://doi.org/10.1021/acscatal.5b00583
Autor:
Elena Ho, Hironao Wakabayashi, Derek Sim, Katherine Tran, Philip J. Fay, Thomas Eugene Thompson, Perry Liu, Lilley Leong, Chandra Patel, Peter J. Kretschmer, J. E. Murphy
Publikováno v:
Blood. 125:392-398
An important negative regulator of factor VIIIa (FVIIIa) cofactor activity is A2 subunit dissociation. FVIII molecules with stabilized activity have been generated by elimination of charged residues at the A1-A2 and A2-A3 interfaces. These molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59668eed1b824abd2ddb7fc3a432f98
https://doi.org/10.1182/blood-2014-02-555656
https://doi.org/10.1182/blood-2014-02-555656
Autor:
Shujun Yuan, Derek Sim, Perry Liu, Peter Bringmann, Martin Rosenbruch, Katalin Kauser, Keith Abe, Jian-Ming Gu
Publikováno v:
Experimental hematology. 60
Vaso-occlusive crisis (VOC) is the most common and debilitating complication of sickle cell disease (SCD); recurrent episodes cause organ damage and contribute to early mortality. Plasma placental growth factor (PlGF) levels are elevated in SCD and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd19745c646859c8750a1a75ead5bb61
https://pubmed.ncbi.nlm.nih.gov/29337222
https://pubmed.ncbi.nlm.nih.gov/29337222
Publikováno v:
Emerging Contaminants, Vol 9, Iss 1, Pp 100198- (2023)
Benoxacor is a safener added to current-use herbicide formulations to protect the target crop from herbicidal toxicity. It is an emerging environmental contaminant that has been detected in surface waters, raising the possibility of human exposure vi
Externí odkaz:
https://doaj.org/article/b8b03dc513f34ef1bd7678f3dd41478d