Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Derek Sharples"'
Autor:
Leonard Amaral, Gabriella Spengler, Derek Sharples, Annamária Molnár, Zsuzsanna Schelz, Joseph Molnár
Publikováno v:
Current Drug Targets. 7:823-841
Bacterial plasmids have a major impact on metabolic function. Lactose fermentation of E. coli or hemolysin B transporter expressed by the plasmids that carry these respective genes could be readily obviated by heterocyclic compounds that readily bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b8d982fd0a2e3762447c2a14d3e62b
https://doi.org/10.2174/138945006777709601
https://doi.org/10.2174/138945006777709601
Autor:
Derek Sharples, Jean Marc Barret, Bridget T. Hill, Jacques Barbe, Christopher M. Farrell, Christiane Santelli-Rouvier
Publikováno v:
European Journal of Medicinal Chemistry. 39:1029-1038
The synthesis of several acridine thioethers is described. These compounds were oxidized to give new sulfoxides and sulfones. Among 23 compounds prepared, 19 were tested in vitro against the human cancer cell lines panel of NCI screening. Activity is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8080bac925f9491b9c181209462e8d73
https://doi.org/10.1016/j.ejmech.2004.06.015
https://doi.org/10.1016/j.ejmech.2004.06.015
Autor:
Krisztina Wolfard, Joseph Molnár, Imre Máthé, Derek Sharples, Peter Forgo, Annamária Molnár, Judit Hohmann, Theresia Thalhammer
Publikováno v:
Planta Medica. 68:454-457
Seven alkaloids were isolated from Sprekelia formosissima, and five from Hymenocallis x festalis. Tazettine, lycorine, haemanthidine and haemanthamine were evaluated for antiproliferative and multidrug resistance (mdr) reversing activity on mouse lym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2425206329687606d2073addcff7b0fd
https://doi.org/10.1055/s-2002-32068
https://doi.org/10.1055/s-2002-32068
Autor:
A Crémieux, A.-M. Galy, Derek Sharples, J Chevalier, J. Barbe, J. P. Galy, H Berny, Pierre Brouant
Publikováno v:
Research in Microbiology. 146:73-83
The antimicrobial activity of several new 9-acridinones and 9-thioalkylacridines towards Escherichia coli, Staphylococcus aureus, Mycobacterium smegmatis and Candida albicans was investigated. Minimal inhibitory, bactericidal and fungicidal concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e602f4ac418709a17550d975fbcb35
https://doi.org/10.1016/0923-2508(96)80272-5
https://doi.org/10.1016/0923-2508(96)80272-5
Autor:
Derek Sharples, Dan Wicksteed
Publikováno v:
Education 3-13. 19:16-19
Summary We believe those whose religious views lead them to be doubtful have a valuable role in teaching RE, not a role for which they should apologise. They should however keep in touch with the dilemmas of life, not deny them, as these provide the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6205e2427ecf39bf8d39548989134a2
https://doi.org/10.1080/03004279185200271
https://doi.org/10.1080/03004279185200271
Autor:
Jean-Pierre Galy, Jacques Barbe, Jacqueline Chevalier, Derek Sharples, A.-M. Galy, Andrée Cremieux, Léon Ngadi
Publikováno v:
European Journal of Medicinal Chemistry. 25:67-70
Some new 1-nitro acridine derivatives were prepared and characterized. These compounds were screened for evaluating their antimicrobial properties against Gram+ bacteria, Gram − bacteria, and mycobacteria as well as fungi. With reference to the res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df8cd00820a2728d408791f765a6bb05
https://doi.org/10.1016/0223-5234(90)90166-z
https://doi.org/10.1016/0223-5234(90)90166-z
Autor:
Christopher M. Farrell, Christiane Santelli-Rouvier, Jean-Marc Barret, Bridget T. Hill, Derek Sharples, Jacques Barbe
Publikováno v:
ChemInform. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bfcc99f661f32dff0f7774eabb99c65
https://doi.org/10.1002/chin.200519164
https://doi.org/10.1002/chin.200519164
Autor:
Andreas Hilgeroth, Gabriella Spengler, János Kiss, Annamária Molnár, Sandrine Gallo, Abdallah Mahamoud, J. Szabo, Joseph Molnár, Derek Sharples, Zsuzsanna Antal, Jacques Barbe
Publikováno v:
European journal of medicinal chemistry. 40(2)
Various resistance mechanisms such as complex formation with DNA, tRNA and MDR1 p-glycoprotein were modified in bacteria and cancer cells in presence of pregnane, pyridoquinoline, and aza-oxafluorene derivatives. Interaction between the compounds, pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cafb9cb5c20c1d7db2073236f06c32f
https://pubmed.ncbi.nlm.nih.gov/15694654
https://pubmed.ncbi.nlm.nih.gov/15694654
Autor:
Rebecca Hodgkinson, Derek Sharples
Publikováno v:
Expert opinion on investigational drugs. 11(8)
Over the past decade many well-tried chemotherapeutic agents have lost their effectiveness. This is due to a phenomenon referred to as multi-drug resistance. The most likely cause of multi-drug resistance is an increase in the activity of an efflux p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b8ec570209cbe07abb73c3094310f7
https://pubmed.ncbi.nlm.nih.gov/12150699
https://pubmed.ncbi.nlm.nih.gov/12150699
Publikováno v:
Archiv der Pharmazie. 334(8-9)
Ten polycyclic derivatives related to ellipticine have been synthesised and tested for their intercalating, reverse transcriptase (RT) inhibitory and multidrug resistance efflux pump inhibitory properties. The intercalating activity and the RT inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9dd72b53816287eda730f9037f5bd6
https://pubmed.ncbi.nlm.nih.gov/11688136
https://pubmed.ncbi.nlm.nih.gov/11688136