Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Derek Saunders"'
Autor:
Petra Bloms-Funke, Michael Schumacher, Song Liu, Diya Su, Jing Li, Philippe Liere, Rainer Rupprecht, Caroline Nothdurfter, Gregor Bahrenberg, Thomas Christoph, Christopher Habermann, Christa Kneip, Wolfgang Schröder, Thomas M. Tzschentke, Derek Saunders
Publikováno v:
European journal of pharmacology. 923
Chronic neuropathic pain (CNP) can result from surgery or traumatic injury, but also from peripheral neuropathies caused by diseases, viral infections, or toxic treatments. Opioids, although very effective for acute pain, do not prevent the developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56528e1f2b1031a9de0c793570631c5b
https://pubmed.ncbi.nlm.nih.gov/35378102
https://pubmed.ncbi.nlm.nih.gov/35378102
Autor:
Klaus Linz, Olaf Will, André Welbers, Virginia Marossek, Rolf Terlinden, Klaus Hansen, Bert Nolte, Irena Loryan, Margareta Hammarlund-Udenaes, Paul Ratcliffe, Achim Kless, Anita Wegert, Derek Saunders, Edmund Hoppe, Felix Held
Drug induced phospholipidosis (PLD) may be observed in the preclinical phase of drug development and pose strategic questions. As lysosomes have a central role in pathogenesis of PLD, assessment of lysosomal concentrations is important for understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477e220a5faacb4b5061bcd395774bb2
https://publica.fraunhofer.de/handle/publica/253775
https://publica.fraunhofer.de/handle/publica/253775
Autor:
Sven Frormann, B.Y. Kögel, Bernd Sundermann, Klaus Linz, Achim Kless, Helmut Sonnenschein, Wolfgang P. Schröder, Stefan Schunk, Werner Englberger, Derek Saunders, Hans Schick, Tieno Germann, Saskia Zemolka, Thomas Christoph, Claudia Hinze, Stefan Oberbörsch, Stephanie Harlfinger
Publikováno v:
ACS Medicinal Chemistry Letters. 5:857-862
In a previous communication, our efforts leading from 1 to the identification of spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amine 2a as analgesic NOP and opioid receptor agonist were disclosed and their favorable in vitro and in vivo pharmacologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38fbb1f07a0eb7a8eeee56a55aa18175
https://doi.org/10.1021/ml500117c
https://doi.org/10.1021/ml500117c
Autor:
Tieno Germann, Bernd Sundermann, Sven Frormann, Helmut Sonnenschein, Hans Schick, Werner Englberger, B.Y. Kögel, Derek Saunders, Achim Kless, Klaus Linz, Stefan Oberbörsch, Stephanie Harlfinger, Saskia Zemolka, Thomas Christoph, Claudia Hinze, Wolfgang P. Schröder, Stefan Schunk
Publikováno v:
ACS Medicinal Chemistry Letters. 5:851-856
We report the discovery of spiro[cyclohexane-pyrano[3,4-b]indole]-amines, as functional nociceptin/orphanin FQ peptide (NOP) and opioid receptor agonists with strong efficacy in preclinical models of acute and neuropathic pain. Utilizing 4-(dimethyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fe90b0366ab101fe23bc576f011c77
https://doi.org/10.1021/ml500116x
https://doi.org/10.1021/ml500116x
Autor:
D Ambrosius, Hartwig Höcker, Axel Wollmer, D Bitter-Suermann, Joachim Grötzinger, Martina Pohl, Derek Saunders, T Kretzschmar, Brandenburg D
Publikováno v:
International Journal of Peptide and Protein Research. 41:362-375
The flexible C-terminal region of the anaphylatoxic peptide C3a was reported to contain the receptor binding site. To elucidate the receptor binding conformation of the C-terminus, as well as to examine a synthetic approach to potential C3a-antagonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf807aabf58b0078a5efe2c6543ab25d
https://doi.org/10.1111/j.1399-3011.1993.tb00452.x
https://doi.org/10.1111/j.1399-3011.1993.tb00452.x
Autor:
Bob Wilffert, Regina Heinzel-Wieland, Derek Saunders, Gerd J. Steffens, Johannes Schneider, Stephan Wnendt
Publikováno v:
European Journal of Pharmacology, 302(1-3), 69-77. ELSEVIER SCIENCE BV
The recombinant bifunctional urokinase variant, M23 (rscu-PA-40 kDA/Hir), comprising the kringle and protease domain of single-chain urokinase-type plasminogen activator and a C-terminal fragment of hirudin in one single-chain molecule, was evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7de2a48c3b6e638503a4f13ed84e5f3
https://doi.org/10.1016/0014-2999(96)00107-0
https://doi.org/10.1016/0014-2999(96)00107-0
Publikováno v:
Pulmonary Pharmacology. 6:33-39
Summary: Secretory leukocyte inhibitor (SLPI) is a potent inhibitor of serine proteinases, but sensitive to oxidative inactivation due to a methionine residue in the active centre of the inhibitor. We compared the potency of an oxidation-resistant mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858165ffd2b569ccddeaa2b9ff33b45a
https://doi.org/10.1006/pulp.1993.1006
https://doi.org/10.1006/pulp.1993.1006
Autor:
Titus Kretzschmar, Derek Saunders, Andreas Klos, Michael Przewosny, Jörg Köhl, Wilfried Bautsch, Martina Pohl, Monika Casaretto
Publikováno v:
European Journal of Biochemistry. 210:185-191
Peptide compounds resembling the receptor-binding C-terminal domain of the anaphylatoxic peptide C3a were synthesized to examine two kinds of C3a antagonism: (a) specific desensitization of C3a-sensitive cells and (b) competitive binding to the C3a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6d0d5dff624d8fb04b4ede3de25ed8
https://doi.org/10.1111/j.1432-1033.1992.tb17407.x
https://doi.org/10.1111/j.1432-1033.1992.tb17407.x
Autor:
Derek Saunders
Publikováno v:
The Journal of Adhesion. 83:611-612
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d6b85520d5bea13911169fa451b1fd2
https://doi.org/10.1080/00218460701537486
https://doi.org/10.1080/00218460701537486
Publikováno v:
Biochemistry. 33(10)
The domain structure and the stability against thermal and chemical denaturation of urokinase-type plasminogen activator (u-PA) have been investigated by NMR spectroscopy and differential scanning calorimetry (DSC). At least five structurally autonom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3522ca828891cc98079d0f093ed96f6
https://pubmed.ncbi.nlm.nih.gov/8130209
https://pubmed.ncbi.nlm.nih.gov/8130209