Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Derek S. Sim"'
Autor:
Derek S. Sim, Cornell R. Mallari, John M. Teare, Richard I. Feldman, Maxine Bauzon, Terry W. Hermiston
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 5, Pp n/a-n/a (2021)
Abstract Background Traumatic injury and the associated acute bleeding are leading causes of death in people aged 1 to 44 years. Acute bleeding in pathological and surgical settings also represents a significant burden to the society. Yet there are n
Externí odkaz:
https://doaj.org/article/14a0e9c3e7554a8ebeb2a6299ca954bd
Publikováno v:
Biomarker Insights, Vol 3, Pp 293-302 (2008)
Stratification of cardiac patients arriving at the emergency department is now being made according to the levels of acute cardiac biomarkers (i.e. cardiac troponin (cTn) or creatine kinase myocardial band (CK-MB)). Ongoing efforts are undertaken in
Externí odkaz:
https://doaj.org/article/9d2821e4f63848f191d560ff6829f600
Autor:
Derek S Sim, Meenal Shukla, Cornell R Mallari, José A. Fernández, Xiao Xu, Doug Schneider, Maxine Bauzon, Terry W Hermiston, Laurent O. Mosnier
Publikováno v:
Blood Advances.
Activated protein C (APC) is a pleiotropic coagulation protease with anticoagulant, anti-inflammatory, and cytoprotective activities. Selective modulation of these APC activities contributes to our understanding of the regulation of these physiologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e216e9bfd3fd7050dbf277811243739b
https://doi.org/10.1182/bloodadvances.2022008740
https://doi.org/10.1182/bloodadvances.2022008740
Autor:
Derek S Sim, Meenal Shukla, Cornell R Mallari, Doug Schneider, Maxine Bauzon, Terry W Hermiston, Laurent O. Mosnier
Publikováno v:
Blood. 140:973-974
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18b6b5c126ed0a0beb7855c9d8d0eee1
https://doi.org/10.1182/blood-2022-158855
https://doi.org/10.1182/blood-2022-158855
Publikováno v:
Blood. 140:5574-5575
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0c5dbd36f533b1463f7c8965a6575a1
https://doi.org/10.1182/blood-2022-169537
https://doi.org/10.1182/blood-2022-169537
Publikováno v:
Thrombosis research. 215
Acute bleeding leads to significant morbidity and mortality. Recombinant wildtype Factor VIIa (WT FVIIa) had been reported to have some therapeutic effects in some clinical trials, however, its use was associated with thromboembolic events. We sought
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70435a000d774bbaf3bfce0fafcffc7f
https://pubmed.ncbi.nlm.nih.gov/35640516
https://pubmed.ncbi.nlm.nih.gov/35640516
Autor:
Derek S. Sim, Terry W. Hermiston, Terrence K. Allen, Daekyeong Bae, Jennifer Gilner, Seung-Chul Kim, Sul Lee, Cornell R. Mallari, Andra H. James
Publikováno v:
American Journal of Obstetrics and Gynecology. 228:S628
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49edcaaa5fbdb7e9296b36f392fc95e1
https://doi.org/10.1016/j.ajog.2022.11.1063
https://doi.org/10.1016/j.ajog.2022.11.1063
Autor:
Allen Ebens, Pui Yan Ho, Maire Rayburn, Mark E Hayes, Scott W. Leonard, James M. Coull, Tumul Srivastava, Somayeh S. Tarighat, Zhen Zhang, Xiao-Jun Li, Agnieszka Czechowicz, Carla Dib, Sze Nok Tam, Andrew Curd, Lan Wang, Mark J. Fiandaca, Marshall Fordyce, Brandon Hriniak, Derek S. Sim
Publikováno v:
Proc Natl Acad Sci U S A
Triplex gene editing relies on binding a stable peptide nucleic acid (PNA) sequence to a chromosomal target, which alters the helical structure of DNA to stimulate site-specific recombination with a single-strand DNA (ssDNA) donor template and elicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d46e966f3f19eb7c7aa2ec80090f8a
https://pubmed.ncbi.nlm.nih.gov/34732575
https://pubmed.ncbi.nlm.nih.gov/34732575
Autor:
Robert Pearson, Florence Tam, Derek S. Sim, Susan Whoriskey, Tumul Srivastava, Allen J. Ebens, Lily Jun Shen Huang, Mark P. Hayes, Zhen Zhang, Andrew Curd, Xiao-Jun Li, James Coull, Marshall Fordyce, Elias Quijano
Publikováno v:
Blood. 134:4645-4645
Homozygous E6V alleles in the beta globin gene cause disease in the majority of sickle cell patients and the use of gene editing technologies to correct this mutation in hematopoietic stem cells offers the potential to cure disease. Approaches utiliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fad12deba36960d4786fc64a2014b06d
https://doi.org/10.1182/blood-2019-127538
https://doi.org/10.1182/blood-2019-127538
Autor:
Athan Kuliopulos, James R. Dilks, Price Blair, Georgios Koukos, Robert Flaumenhaft, Sarah Beaudry, Derek S. Sim, Bradley M. Denker, Louisa Dowal
Publikováno v:
Proceedings of the National Academy of Sciences. 108:2951-2956
G protein-coupled receptors (GPCRs) can assume multiple conformations and possess multiple binding sites. Whereas endogenous agonists acting at the orthosteric binding site stabilize the active receptor conformation, small molecules that act at nonor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe9445f562d5fad99aae44d90ee2a48
https://doi.org/10.1073/pnas.1014863108
https://doi.org/10.1073/pnas.1014863108