Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Derek S. Park"'
Autor:
Derek S Park, Afua A Akuffo, David E Muench, H Leighton Grimes, Pearlie K Epling-Burnette, Philip K Maini, Alexander R A Anderson, Michael B Bonsall
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 4, p e1006913 (2019)
Clonal hematopoiesis of indeterminate potential (CHIP) is a recently identified process where older patients accumulate distinct subclones defined by recurring somatic mutations in hematopoietic stem cells. CHIP's implications for stem cell transplan
Externí odkaz:
https://doaj.org/article/d34cb7158def4953863dc0d44bdd6782
Autor:
Alexander R.A. Anderson, Robert A. Gatenby, Michael B. Bonsall, Philip K. Maini, Kimberly A. Luddy, Mark Robertson-Tessi, Derek S. Park
Expanded parameter analysis for model parameter c. Greater T cell sensitivity to Tregs reduces the size of the Goldilocks Window.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e5708f5f1a2deca2ff090193b40b92e
https://doi.org/10.1158/0008-5472.22422086.v1
https://doi.org/10.1158/0008-5472.22422086.v1
Autor:
Alexander R.A. Anderson, Robert A. Gatenby, Michael B. Bonsall, Philip K. Maini, Kimberly A. Luddy, Mark Robertson-Tessi, Derek S. Park
Detailed legends for supplementary figures S1 - S7. This includes comparisons to baseline model values as well as the evaluation of the impacts of parameter variation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1050ddb33c3405f6c883c9444825f836
https://doi.org/10.1158/0008-5472.22422068
https://doi.org/10.1158/0008-5472.22422068
Data from The Goldilocks Window of Personalized Chemotherapy: Getting the Immune Response Just Right
Autor:
Alexander R.A. Anderson, Robert A. Gatenby, Michael B. Bonsall, Philip K. Maini, Kimberly A. Luddy, Mark Robertson-Tessi, Derek S. Park
The immune system is a robust and often untapped accomplice of many standard cancer therapies. A majority of tumors exist in a state of immune tolerance where the patient's immune system has become insensitive to the cancer cells. Because of its lymp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::401b08cf954033ec54f44fb39e3788ff
https://doi.org/10.1158/0008-5472.c.6511121.v1
https://doi.org/10.1158/0008-5472.c.6511121.v1
Autor:
Juan C. Hernandez-Prera, Sean J. Yoder, Bruce M. Wenig, Anders Berglund, Kristen J. Otto, Jimmy J. Caudell, Julie E. Hallanger-Johnson, Travis Gerke, Robbert J.C. Slebos, Cesar A. Lam, Barbara A. Centeno, Natarajan Raghunand, Derek S. Park, Jordan H. Creed, Pablo Valderrabano, Valentina Tarasova, Janis V. de la Iglesia, Colleen Veloski, Christine H. Chung, Alexander R. A. Anderson
Publikováno v:
Thyroid
Background: RAS gene family mutations are the most prevalent in thyroid nodules with indeterminate cytology and are present in a wide spectrum of histological diagnoses. We evaluated differentially expressed genes and signaling pathways across the hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3b81345f3d7f636307a5c484390b8d
https://europepmc.org/articles/PMC7864115/
https://europepmc.org/articles/PMC7864115/
Autor:
Kimberly Luddy, Robert A. Gatenby, Mark Robertson-Tessi, Alexander R. A. Anderson, Derek S. Park, Cliona O'Farrelly
Publikováno v:
Cancer research. 80(23)
Deaths from cancer are mostly due to metastatic disease that becomes resistant to therapy. A mainstay treatment for many cancers is chemotherapy, for which the dosing strategy is primarily limited by patient toxicity. While this MTD approach builds u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278ace7d18281d988ea8ac5c603b2fb4
https://pubmed.ncbi.nlm.nih.gov/32934022
https://pubmed.ncbi.nlm.nih.gov/32934022
Autor:
Jeffrey West, Joel S. Brown, Luddy K, Alexander R. A. Anderson, Mark Robertson-Tessi, Cathal Harmon, Drew F. K. Williamson, Hung T. Khong, Derek S. Park
PurposeIn an upcoming clinical trial at the Moffitt Cancer Center for women with stage 2/3 estrogen receptor–positive breast cancer, treatment with an aromatase inhibitor and a PD-L1 checkpoint inhibitor combination will be investigated to lower a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84c5d2cfbcb70df9ba0fe16953aaeb39
https://europepmc.org/articles/PMC6873943/
https://europepmc.org/articles/PMC6873943/
Autor:
Philip K. Maini, Alexander R. A. Anderson, Luddy K, Mark Robertson-Tessi, Derek S. Park, Michael B. Bonsall, Robert A. Gatenby
The immune system is increasingly being recognized for its untapped potential in being recruited to attack tumors in cancer therapy. The main challenge, however, is that most tumors exist in a state of immune tolerance where the patient's immune syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9514dc19b9603417609cbb387960f81
https://doi.org/10.1101/495184
https://doi.org/10.1101/495184
Publikováno v:
Mathematical Modelling of Natural Phenomena. 4:117-133
Tumor growth and progression is a complex phenomenon dependent on the interaction of multiple intrinsic and extrinsic factors. Necessary for tumor development is a small subpop- ulation of potent cells, so-called cancer stem cells, that can undergo a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68a8074c93d3ab8bbe61dfc0993ee92e
https://doi.org/10.1051/mmnp/20094305
https://doi.org/10.1051/mmnp/20094305
Publikováno v:
FEMS yeast research. 13(2)
Viruses that infect fungi have a ubiquitous distribution and play an important role in structuring fungal communities. Most of these viruses have an unusual life history in that they are propagated exclusively via asexual reproduction or fission of f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d3e84cf9bf075c44f0748ef14ede6b
https://pubmed.ncbi.nlm.nih.gov/23122216
https://pubmed.ncbi.nlm.nih.gov/23122216