Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Derek R. Melvin"'
Publikováno v:
FEBS Letters. 481:261-265
The insulin-responsive glucose transporter, Glut4, exhibits a unique subcellular distribution such that in the absence of insulin >95% of the protein is stored within intracellular membranes. In response to insulin, Glut4 exhibits a large mobilisatio
Autor:
David E. James, Annette M. Shewan, Sally Martin, Derek R. Melvin, Gwyn W. Gould, Brad J. Marsh
Publikováno v:
Biochemical Journal. 350:99-107
The insulin-responsive glucose transporter GLUT4 is targeted to a post-endocytic compartment in adipocytes, from where it moves to the cell surface in response to insulin. Previous studies have identified two cytosolic targeting motifs that regulate
Autor:
Gwyn W. Gould, Brad J. Marsh, Derek R. Melvin, Richard A. Alm, Laura B. Martin, Sally Martin, David E. James
Publikováno v:
Europe PubMed Central
The carboxy terminus of GLUT-4 contains a functional internalization motif (Leu-489Leu-490) that helps maintain its intracellular distribution in basal adipocytes. This motif is flanked by the major phosphorylation site in this protein (Ser-488), whi
Autor:
Helen Chapman, Derek R. Melvin, Carolyn A. Lister, Gwyn W. Gould, Valerie H. Maier, Gregory J. Murphy
Publikováno v:
Diabetes. 49(4)
Insulin stimulation of adipose and muscle cells results in the translocation of GLUT4 from an intracellular location to the plasma membrane; this translocation is defective in insulin resistance. Studies have suggested an important role for synaptobr
Autor:
Gwyn W. Gould, Susan Kane, Margaret I. Arbuckle, Derek R. Melvin, Michael J. Seatter, Lisa M. Porter
Publikováno v:
Biochemistry. 36(21)
The brain-type glucose transporter (GLUT3) is a high-affinity transporter for D-glucose and D-galactose and is a member of a family of mammalian sugar transporters, each of which are proposed to adopt a secondary structure containing 12 transmembrane
Publikováno v:
Europe PubMed Central
The available data suggest that GLUT4 does populate the recycling endosomal system to some extent, but that a large proportion of the intracellular GLUT4 resides in a compartment that is devoid of transferrin receptors and may have properties more ak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf4c0eb2fc0ef3c477fe9d75c396f70
http://europepmc.org/abstract/med/9388584
http://europepmc.org/abstract/med/9388584