Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Derek R. Laver"'
Autor:
Michael J. Maxwell, Chris Thekkedam, Cedric Lamboley, Yanni K.-Y. Chin, Theo Crawford, Jennifer J. Smith, Junyu Liu, Xinying Jia, Irina Vetter, Derek R. Laver, Bradley S. Launikonis, Angela Dulhunty, Eivind A. B. Undheim, Mehdi Mobli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Insect toxins with tandem repeats of neurotoxin domains have been found with enhanced receptor avidity. Here, the authors describe a bivalent toxin from remipede venom that targets ryanodine receptors, a rare target for animal venoms.
Externí odkaz:
https://doaj.org/article/ecfef30c1c5e4dc1ab651ec6f5d81576
Autor:
Jacqueline M. Gulbis, Ruitao Jin, Oliver B. Clarke, Sitong He, David M. Miller, Derek R. Laver, Katrina A. Black, Paul Johnson, Christopher J. Burns, Carol V. Robinson, Jani Reddy Bolla, Monique J. Windley, Brian J. Smith, Adam P. Hill
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
The canonical mechanistic model explaining potassium channel gating is of a conformational change that alternately dilates and constricts a collar-like intracellular entrance to the pore. It is based on the premise that K+ ions maintain a complete hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669d9b4c0e835a85598473df29565c46
http://link.springer.com/article/10.1038/s41467-020-16842-0
http://link.springer.com/article/10.1038/s41467-020-16842-0
Publikováno v:
Molecular Pharmacology. 97:250-258
Phenytoin is a hydantoin derivative that is used clinically for the treatment of epilepsy and has been reported to have antiarrhythmic actions on the heart. In a failing heart, the elevated diastolic Ca2+ leak from the sarcoplasmic reticulum can be n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2bd0ed6d99f8a7aac0de72ab6dc3862
https://doi.org/10.1124/mol.119.117721
https://doi.org/10.1124/mol.119.117721
Autor:
Paul Johnson, Peter M. Colman, Jani Reddy Bolla, Jacqueline M. Gulbis, Ruitao Jin, Brian J. Smith, Oliver B. Clarke, Agalya Periasamy, Di Wu, Peter E. Czabotar, Sitong He, Derek R. Laver, Ahmad Wardak, Carol V. Robinson, Katrina A. Black
Ion currents through potassium channels are gated. Constriction of the ion conduction pathway at the inner helix bundle, the textbook ‘gate’ of Kir potassium channels, has been shown to be an ineffective permeation control, creating a rift in our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdda3d0f0828013151fa8d078f10e0ef
https://doi.org/10.1101/2021.09.21.461288
https://doi.org/10.1101/2021.09.21.461288
Autor:
Cris dos Remedios, Bjorn C. Knollmann, Nicole A. Beard, Ye Wint Oo, Nieves Gomez-Hurtado, Peter C. M. Molenaar, Robyn T. Rebbeck, Derek R. Laver, Razvan L. Cornea, Kafa Walweel, Dirk F. van Helden
Publikováno v:
Journal of Molecular and Cellular Cardiology. 130:96-106
Calmodulin (CaM) is a Ca-binding protein that binds to, and can directly inhibit cardiac ryanodine receptor calcium release channels (RyR2). Animal studies have shown that RyR2 hyperphosphorylation reduces CaM binding to RyR2 in failing hearts, but d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec3da4085ae22692dcd0aedb4c6247e
https://doi.org/10.1016/j.yjmcc.2019.03.018
https://doi.org/10.1016/j.yjmcc.2019.03.018
Publikováno v:
IFAC-PapersOnLine. 52:238-243
Cyclic calcium release and uptake in heart cells has an important role in heart rhythm and contraction, and it is known that the malregulation of calcium release is a predictor for cardiac arrhythmia. A model of this calcium release process was propo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80a94fd2f8593fb6f06515336247058d
https://doi.org/10.1016/j.ifacol.2019.12.264
https://doi.org/10.1016/j.ifacol.2019.12.264
Autor:
Dirk F van Helden, Paul A Thomas, Peter J Dosen, Mohammad S Imtiaz, Derek R Laver, Geoffrey K Isbister
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 2, p e2722 (2014)
BACKGROUND: This study examines the use of topical pharmacological agents as a snakebite first aid where slowing venom reaching the circulation prevents systemic toxicity. It is based on the fact that toxin molecules in most snake venoms are large mo
Externí odkaz:
https://doaj.org/article/fe85e4391cc043129470912a7e7c9ce8
BACKGROUND: Phenytoin has long been used to treat epilepsy and for some time as an antiarrhythmic drug (AAD). It is known that the diastolic calcium leakage through dysfunctional cardiac ryanodine receptors (RyR2) is a mechanism for arrhythmias in he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f6e8a0e0c7e56062ad629a1db5d9606
https://doi.org/10.21203/rs.3.rs-215117/v1
https://doi.org/10.21203/rs.3.rs-215117/v1
Autor:
Derek R. Laver, Jeffrey N. Johnston, Suzanne M. Batiste, Abigail N. Smith, Bjorn C. Knollmann, Dmytro O. Kryshtal, Christian L Egly, Daniel J. Blackwell
Publikováno v:
Circ Res
Rationale: The class Ic antiarrhythmic drug flecainide prevents ventricular tachyarrhythmia in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT), a disease caused by hyperactive RyR2 (cardiac ryanodine receptor) mediated calc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb27ceb566c06c05429d565316ab39f6
https://pubmed.ncbi.nlm.nih.gov/33539226
https://pubmed.ncbi.nlm.nih.gov/33539226
Autor:
Jiao Li, Mohammad S Imtiaz, Nicole A Beard, Angela F Dulhunty, Rick Thorne, Dirk F vanHelden, Derek R Laver
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58334 (2013)
Here we investigate how ß-adrenergic stimulation of the heart alters regulation of ryanodine receptors (RyRs) by intracellular Ca(2+) and Mg(2+) and the role of these changes in SR Ca(2+) release. RyRs were isolated from rat hearts, perfused in a La
Externí odkaz:
https://doaj.org/article/22832563eeeb43d6a5c9684c1aeffdd5