Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Derek R, Moen"'
1
Enzyme Replacement Therapy for Mucopolysaccharidosis IIID using Recombinant Human α-N-Acetylglucosamine-6-Sulfatase in Neonatal Mice
Autor: Shan Li, Sean Ekins, Feng Wang, Steven Q. Le, Tsui-Fen Chou, Chelsee Sauni, Brett Lomenick, Xiaoyi Zhang, Patricia I. Dickson, Shih Hsin Kan, Srikanth Singamsetty, Jill Wood, Derek R. Moen
Publikováno v: Molecular Pharmaceutics. 18:214-227
There is currently no cure or effective treatment available for mucopolysaccharidosis type IIID (MPS IIID, Sanfilippo syndrome type D), a lysosomal storage disorder (LSD) caused by the deficiency of α-N-acetylglucosamine-6-sulfatase (GNS). The clini
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd63ec9bdd3841a50bd5fb7d1ce7212f
https://doi.org/10.1021/acs.molpharmaceut.0c00831
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2
Conserved L464 in p97 D1-D2 linker is critical for p97 cofactor regulated ATPase activity
Autor: Shan Li, Lin Gui, Henry J. Lin, Derek R. Moen, Tsui-Fen Chou, Rod Carlo A Columbres, Purbasha Nandi, Po-Lin Chiu, Daniel E. Wong, Xiaoyi Zhang
Publikováno v: Biochem J
p97 protein is a highly conserved, abundant, functionally diverse, structurally dynamic homohexameric AAA enzyme-containing N, D1, and D2 domains. A truncated p97 protein containing the N and D1 domains and the D1–D2 linker (ND1L) exhibits 79% of w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e26f0be1a3bb28b905b5125ad17906c0
https://pubmed.ncbi.nlm.nih.gov/34405853
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3
Enzyme Replacement Therapy for Mucopolysaccharidosis IIID using Recombinant Human α
Autor: Feng, Wang, Derek R, Moen, Chelsee, Sauni, Shih-Hsin, Kan, Shan, Li, Steven Q, Le, Brett, Lomenick, Xiaoyi, Zhang, Sean, Ekins, Srikanth, Singamsetty, Jill, Wood, Patricia I, Dickson, Tsui-Fen, Chou
Publikováno v: Mol Pharm
There is currently no cure or effective treatment available for mucopolysaccharidosis type IIID (MPS IIID, Sanfilippo syndrome type D), a lysosomal storage disorder (LSD) caused by the deficiency of α-N-acetylglucosamine-6-sulfatase (GNS). The clini
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37d3b572cb04f31af7df8666f6f44bc9
https://pubmed.ncbi.nlm.nih.gov/33320673
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5
Evaluating p97 Inhibitor Analogues for Potency against p97-p37 and p97-Npl4-Ufd1 Complexes
Autor: Frank J. Schoenen, Tsui-Fen Chou, Kelin Li, Henry J. Lin, Daniel E. Wong, Lin Gui, Patrick Porubsky, Shan Li, Kevin J. Frankowski, Xiaoyi Zhang, Derek R. Moen
Publikováno v: ChemMedChem
We previously found that the p97 cofactor, p47, significantly decreased the potency of some ATP-competitive p97 inhibitors such as ML240 [2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine] and ML241 [2-(2H-benzo[b][1,4]oxazin-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2265dd842ec277dcfe756ba4605530ba
https://pubmed.ncbi.nlm.nih.gov/27043824
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7
Evaluating p97 inhibitor analogues for their domain selectivity and potency against the p97-p47 complex
Autor: Frank J. Schoenen, Derek R. Moen, Chen Jie Fang, Lin Gui, Xiaoyi Zhang, Tsui-Fen Chou, Henry J. Lin, Kevin J. Frankowski, Kelin Li
Publikováno v: ChemMedChem, vol 10, iss 1
We previously found that p97 ATPase inhibitors 2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine (ML240) and 2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine (ML241) specifically target the D2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86717e04d56be9aa4f16cffd102fa066
https://escholarship.org/uc/item/6wm7949v
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