Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Derek Parsonage"'
Autor:
Anthony E. Postiglione, Laquaundra L. Adams, Ese S. Ekhator, Anuoluwapo E. Odelade, Supriya Patwardhan, Meenal Chaudhari, Avery S. Pardue, Anjali Kumari, William A. LeFever, Olivia P. Tornow, Tamer S. Kaoud, Johnathan Neiswinger, Jun Seop Jeong, Derek Parsonage, Kimberly J. Nelson, Dukka B. Kc, Cristina M. Furdui, Heng Zhu, Andrew J. Wommack, Kevin N. Dalby, Ming Dong, Leslie B. Poole, Jeremiah D. Keyes, Robert H. Newman
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107817- (2023)
Summary: Extracellular signal-regulated kinases 1 and 2 (ERK1/2) are dysregulated in many pervasive diseases. Recently, we discovered that ERK1/2 is oxidized by signal-generated hydrogen peroxide in various cell types. Since the putative sites of oxi
Externí odkaz:
https://doaj.org/article/f86f308d6824464da8ac7565dac3a50d
Autor:
Kali F. Crofts, Courtney L. Page, Stephanie M. Swedik, Beth C. Holbrook, Allison K. Meyers, Xuewei Zhu, Derek Parsonage, Marlena M. Westcott, Martha A. Alexander-Miller
Publikováno v:
Vaccines, Vol 11, Iss 7, p 1261 (2023)
Subunit or inactivated vaccines comprise the majority of vaccines used against viral and bacterial pathogens. However, compared to their live/attenuated counterparts, these vaccines often demonstrate reduced immunogenicity, requiring multiple booster
Externí odkaz:
https://doaj.org/article/f131269992cf4bb69560af2cc10b0606
Autor:
Leslie B. Poole, Derek Parsonage, Susan Sergeant, Leslie R. Miller, Jingyun Lee, Cristina M. Furdui, Floyd H. Chilton
Publikováno v:
Biotechnology for Biofuels, Vol 13, Iss 1, Pp 1-15 (2020)
Abstract Background Dietary omega-3 (n-3), long chain (LC-, ≥ 20 carbons), polyunsaturated fatty acids (PUFAs) derived largely from marine animal sources protect against inflammatory processes and enhance brain development and function. With the de
Externí odkaz:
https://doaj.org/article/007456e8de4942cb80063d40080c78ba
Autor:
Lance K. Blevins, Derek Parsonage, Melissa B. Oliver, Elizabeth Domzalski, W. Edward Swords, Martha A. Alexander-Miller
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Streptococcus pneumoniae (Spn) causes a variety of disease states including fatal bacterial pneumonia. Our previous finding that introduction of Spn into an animal with ongoing influenza virus infection resulted in a CD8+ T cell population with reduc
Externí odkaz:
https://doaj.org/article/487d20d62ae04adca800f3a5a71d8dac
Autor:
Minh V. Huynh, Derek Parsonage, Tom E. Forshaw, Venkata R. Chirasani, G. Aaron Hobbs, Hanzhi Wu, Jingyun Lee, Cristina M. Furdui, Leslie B. Poole, Sharon L. Campbell
The development of mutant-selective inhibitors for the KRASG12C allele has generated considerable excitement. These KRASG12C inhibitors covalently engage the mutant C12 thiol located within the phosphoryl binding loop of RAS, locking the KRASG12C pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d179fea6ae88ced5795a169e74ee2824
https://doi.org/10.1101/2022.04.03.486828
https://doi.org/10.1101/2022.04.03.486828
Autor:
Minh V. Huynh, Derek Parsonage, Tom E. Forshaw, Venkat R. Chirasani, G. Aaron Hobbs, Hanzhi Wu, Jingyun Lee, Cristina M. Furdui, Leslie B. Poole, Sharon L. Campbell
Publikováno v:
Journal of Biological Chemistry. 298:102186
The recent development of mutant-selective inhibitors for the oncogenic KRAS
Autor:
Ryan A. Mehl, Leslie B. Poole, Joaquín Dalla Rizza, W. Todd Lowther, Lía M. Randall, Derek Parsonage, Javier Santos, Ana Denicola
Publikováno v:
Free Radic Biol Med
Peroxiredoxins (Prx) are enzymes that efficiently reduce hydroperoxides through active participation of cysteine residues (C(P), C(R)). The first step in catalysis, the reduction of peroxide substrate, is fast, 10(7) − 10(8) M(−1)s(−1) for huma
Autor:
Justin A. Shapiro, Al Claiborne, Joanna B. Goldberg, Matthew R. Redinbo, E. Lucile White, Robert Bostwick, William M. Wuest, Derek Parsonage, John J. Varga, William G. Walton, Larry J. Ross
Publikováno v:
ChemMedChem. 14:78-82
Antibiotics with novel mechanisms of action are desperately needed to combat the increasing rates of multidrug-resistant infections. Bacterial pantothenate kinase (PanK) has emerged as a target of interest to cut off the biosynthesis of coenzyme A. H
Autor:
Floyd H. Chilton, Leslie R. Miller, Susan Sergeant, Derek Parsonage, Leslie B. Poole, Cristina M. Furdui, Jingyun Lee
Publikováno v:
Biotechnology for Biofuels
Biotechnology for Biofuels, Vol 13, Iss 1, Pp 1-15 (2020)
Biotechnology for Biofuels, Vol 13, Iss 1, Pp 1-15 (2020)
BackgroundDietary omega-3 (n-3), long chain (LC-, ≥ 20 carbons), polyunsaturated fatty acids (PUFAs) derived largely from marine animal sources protect against inflammatory processes and enhance brain development and function. With the depletion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94393e777b42137f145df7bb8b880b70
Autor:
Seung-Hyun Cho, Derek Parsonage, Casey Thurston, Rachel J. Dutton, Leslie B. Poole, Jean-Francois Collet, Jon Beckwith
Publikováno v:
mBio, Vol 3, Iss 2 (2012)
ABSTRACT The Escherichia coli membrane protein DsbD functions as an electron hub that dispatches electrons received from the cytoplasmic thioredoxin system to periplasmic oxidoreductases involved in protein disulfide isomerization, cytochrome c bioge
Externí odkaz:
https://doaj.org/article/1fe012d034b44db2957d82a97e358eb2