The Trypanosoma Brucei KIFC1 Kinesin Ensures the Fast Antibody Clearance Required for Parasite Infectivity

Autor: Laurence Lecordier, Sophie Uzureau, Gilles Vanwalleghem, Magali Deleu, Jean-Marc Crowet, Paul Barry, Barry Moran, Paul Voorheis, Andra-Cristina Dumitru, Yoshiki Yamaryo-Botté, Marc Dieu, Patricia Tebabi, Benoit Vanhollebeke, Laurence Lins, Cyrille Y. Botté, David Alsteens, Yves Dufrêne, David Pérez-Morga, Derek P. Nolan, Etienne Pays

Publikováno v: iScience, Vol 23, Iss 9, Pp 101476- (2020)

Summary: Human innate immunity to Trypanosoma brucei involves the trypanosome C-terminal kinesin TbKIFC1, which transports internalized trypanolytic factor apolipoprotein L1 (APOL1) within the parasite. We show that TbKIFC1 preferentially associates

Externí odkaz: https://doaj.org/article/6a371ab7ad8949d99821c1fe7af3434e

Trypanosoma brucei Secreted Aromatic Ketoacids Activate the Nrf2/HO-1 Pathway and Suppress Pro-inflammatory Responses in Primary Murine Glia and Macrophages

Autor: Nicole K. Campbell, David G. Williams, Hannah K. Fitzgerald, Paul J. Barry, Clare C. Cunningham, Derek P. Nolan, Aisling Dunne

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

African trypanosomes, such as Trypanosoma brucei (T. brucei), are protozoan parasites of the mammalian vasculature and central nervous system that are best known for causing fatal human sleeping sickness. As exclusively extracellular parasites, trypa

Externí odkaz: https://doaj.org/article/c8debaae71514200868c058fdb41129d

Metabolic reprogramming during the Trypanosoma brucei life cycle [version 1; referees: 4 approved]

Autor: Terry K. Smith, Frédéric Bringaud, Derek P. Nolan, Luisa M. Figueiredo

Publikováno v: F1000Research, Vol 6 (2017)

Cellular metabolic activity is a highly complex, dynamic, regulated process that is influenced by numerous factors, including extracellular environmental signals, nutrient availability and the physiological and developmental status of the cell. The c

Externí odkaz: https://doaj.org/article/e06cd16b84364004811a0cb66f951825

Genetic and immunological basis of human African trypanosomiasis

Autor: Derek P. Nolan, Etienne Pays

Publikováno v: Current opinion in immunology, 72
Current Opinion in Immunology

Human African trypanosomiasis, or sleeping sickness, results from infection by two subspecies of the protozoan flagellate parasite Trypanosoma brucei, termed Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, prevalent in western and ea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00a9470051daa7c206af69366727ce6
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/321142

Queuine Micronutrient Deficiency Promotes Warburg Metabolism and Reversal of the Mitochondrial ATP Synthase in Hela Cells

Autor: Patti Hayes, Claire Fergus, Magda Ghanim, Derek P. Nolan, Vincent P. Kelly, Francesca Tuorto, Callum J. McGrenaghan, Lyubomyr Burtnyak, Cansu Cirzi

Publikováno v: Nutrients
Volume 12
Issue 3
Nutrients 12 (2020). doi:10.3390/nu12030871
info:cnr-pdr/source/autori:Hayes, Patti; Fergus, Claire; Ghanim, Magda; Cirzi, Cansu; Burtnyak, Lyubomyr; McGrenaghan, Callum J.; Tuorto, Francesca; Nolan, Derek P.; Kelly, Vincent P./titolo:Queuine Micronutrient Deficiency Promotes Warburg Metabolism and Reversal of the Mitochondrial ATP Synthase in Hela Cells/doi:10.3390%2Fnu12030871/rivista:Nutrients/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:12
Nutrients, Vol 12, Iss 3, p 871 (2020)

Queuine is a eukaryotic micronutrient, derived exclusively from eubacteria. It is incorporated into both cytosolic and mitochondrial transfer RNA to generate a queuosine nucleotide at position 34 of the anticodon loop. The transfer RNA of primary tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da8913a07ed864457f1e83335de2a38