The Trypanosoma brucei-Derived Ketoacids, Indole Pyruvate and Hydroxyphenylpyruvate, Induce HO-1 Expression and Suppress Inflammatory Responses in Human Dendritic Cells

Autor: Hannah K. Fitzgerald, Sinead A. O’Rourke, Eva Desmond, Nuno G. B. Neto, Michael G. Monaghan, Miriam Tosetto, Jayne Doherty, Elizabeth J. Ryan, Glen A. Doherty, Derek P. Nolan, Jean M. Fletcher, Aisling Dunne

Publikováno v: Antioxidants, Vol 11, Iss 1, p 164 (2022)

The extracellular parasite and causative agent of African sleeping sickness Trypanosoma brucei (T. brucei) has evolved a number of strategies to avoid immune detection in the host. One recently described mechanism involves the conversion of host-deri

Externí odkaz: https://doaj.org/article/daea71fc4daf47e5b167422d9b5c9366

The Trypanosome-Derived Metabolite Indole-3-Pyruvate Inhibits Prostaglandin Production in Macrophages by Targeting COX2

Autor: Derek P. Nolan, Zbigniew Zaslona, Luke A. J. O'Neill, Anne F. McGettrick, Victoria J. Tyrrell, Valerie B. O'Donnell, Sarah E. Corcoran, Ciana Diskin

Publikováno v: The Journal of Immunology. 207:2551-2560

The protozoan parasite Trypanosoma brucei is the causative agent of the neglected tropical disease human African trypanosomiasis, otherwise known as sleeping sickness. Trypanosomes have evolved many immune-evasion mechanisms to facilitate their own s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad0b901479d357fabbe2f3a701edde5
https://doi.org/10.4049/jimmunol.2100402

Metabolic reprogramming during the Trypanosoma brucei life cycle [version 1; referees: 4 approved]

Autor: Terry K. Smith, Frédéric Bringaud, Derek P. Nolan, Luisa M. Figueiredo

Publikováno v: F1000Research, Vol 6 (2017)

Cellular metabolic activity is a highly complex, dynamic, regulated process that is influenced by numerous factors, including extracellular environmental signals, nutrient availability and the physiological and developmental status of the cell. The c

Externí odkaz: https://doaj.org/article/e06cd16b84364004811a0cb66f951825

Identification and characterization of a stage specific membrane protein involved in flagellar attachment in Trypanosoma brucei.

Autor: Katherine Woods, Noirin Nic a'Bhaird, Clodagh Dooley, David Perez-Morga, Derek P Nolan

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e52846 (2013)

Flagellar attachment is a visibly striking morphological feature of African trypanosomes but little is known about the requirements for attachment at a molecular level. This study characterizes a previously undescribed membrane protein, FLA3, which p

Externí odkaz: https://doaj.org/article/40b5dd433b7c49fd9e46cf1ae7186dcd

Queuine Micronutrient Deficiency Promotes Warburg Metabolism and Reversal of the Mitochondrial ATP Synthase in Hela Cells

Autor: Patti Hayes, Claire Fergus, Magda Ghanim, Derek P. Nolan, Vincent P. Kelly, Francesca Tuorto, Callum J. McGrenaghan, Lyubomyr Burtnyak, Cansu Cirzi

Publikováno v: Nutrients
Volume 12
Issue 3
Nutrients 12 (2020). doi:10.3390/nu12030871
info:cnr-pdr/source/autori:Hayes, Patti; Fergus, Claire; Ghanim, Magda; Cirzi, Cansu; Burtnyak, Lyubomyr; McGrenaghan, Callum J.; Tuorto, Francesca; Nolan, Derek P.; Kelly, Vincent P./titolo:Queuine Micronutrient Deficiency Promotes Warburg Metabolism and Reversal of the Mitochondrial ATP Synthase in Hela Cells/doi:10.3390%2Fnu12030871/rivista:Nutrients/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:12
Nutrients, Vol 12, Iss 3, p 871 (2020)

Queuine is a eukaryotic micronutrient, derived exclusively from eubacteria. It is incorporated into both cytosolic and mitochondrial transfer RNA to generate a queuosine nucleotide at position 34 of the anticodon loop. The transfer RNA of primary tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da8913a07ed864457f1e83335de2a38