Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Derek P. DiRocco"'
Autor:
Alice S. Chen-Plotkin, Ghazaleh Sadri-Vakili, George J. Yohrling, Melissa W. Braveman, Caroline L. Benn, Kelly E. Glajch, Derek P. DiRocco, Laurie A. Farrell, Dimitri Krainc, Silvia Gines, Marcy E. MacDonald, Jang-Ho J. Cha
Publikováno v:
Neurobiology of Disease, Vol 22, Iss 2, Pp 233-241 (2006)
Huntington's disease (HD) is a neurodegenerative disease caused by expansion of a polyglutamine tract within the huntingtin protein. Transcriptional dysregulation has been implicated in HD pathogenesis; recent evidence suggests a defect in Sp1-mediat
Externí odkaz:
https://doaj.org/article/84d817405df14df5b6f4b93444f827d8
Autor:
Benjamin D. Humphreys, Flavia Gomes Machado, Benjamin L. Ebert, Susanne V. Fleig, Rebekka K. Schneider, Joel M. Henderson, Rafael Kramann, Derek P. DiRocco, Philip A. Bondzie
Publikováno v:
Cell Stem Cell. 16(1):51-66
Mesenchymal stem cells (MSCs) reside in the perivascular niche of many organs, including kidney, lung, liver, and heart, although their roles in these tissues are poorly understood. Here, we demonstrate that Gli1 marks perivascular MSC-like cells tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b6cc1ebe82635b921a06193f908442
Autor:
Andreas Hofmeister, Jing Liu, Andrew P. McMahon, Ivica Grgic, Benjamin D. Humphreys, Jeremy S. Duffield, A. Michaela Krautzberger, Derek P. DiRocco, Susanne V. Fleig, Matthew A. Lalli, Bruce J. Aronow
Publikováno v:
Journal of the American Society of Nephrology. 25:1979-1990
Myofibroblasts secrete matrix during chronic injury, and their ablation ameliorates fibrosis. Development of new biomarkers and therapies for CKD will be aided by a detailed analysis of myofibroblast gene expression during the early stages of fibrosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7308c0a7698bbfd8fe212e6f0979ebee
https://doi.org/10.1681/asn.2013101143
https://doi.org/10.1681/asn.2013101143
Publikováno v:
Kidney International
The kidney is a complex organ with over 30 different cell types, and understanding the lineage relationships between these cells is challenging. During nephrogenesis, a central question is how the coordinated morphogenesis, growth, and differentiatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c936106e7f689fd0e59faedcb4162a
Publikováno v:
The Journal of Pathology. 231:273-289
Fibrosis and scar formation results from chronic progressive injury in virtually every tissue and affects a growing number of people around the world. Myofibroblasts drive fibrosis, and recent work has demonstrated that mesenchymal cells, including p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ce9b4d04aff0f56f53071a215d6e22a
https://doi.org/10.1002/path.4253
https://doi.org/10.1002/path.4253
Autor:
Akio Kobayashi, Benjamin D. Humphreys, Derek P. DiRocco, Andrew P. McMahon, Makoto Mark Taketo
Publikováno v:
Journal of the American Society of Nephrology. 24:1399-1412
Injury to the adult kidney induces a number of developmental genes thought to regulate repair, including Wnt4. During kidney development, early nephron precursors and medullary stroma both express Wnt4, where it regulates epithelialization and contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056c8f8638fb24ba4d88deac241b20e9
https://doi.org/10.1681/asn.2012050512
https://doi.org/10.1681/asn.2012050512
Publikováno v:
The Journal of Neuroscience. 29:2393-2403
Cocaine sensitization is produced by repeated exposure to the drug and is thought to reflect neuroadaptations that contribute to addiction. Here, we identify the Ca2+/calmodulin-stimulated adenylyl cyclases, type 1 (AC1) and type 8 (AC8), as novel re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ac8ed1c12b26a987fddf33b6786289
https://doi.org/10.1523/jneurosci.4356-08.2009
https://doi.org/10.1523/jneurosci.4356-08.2009
Autor:
Jang Ho J. Cha, Melissa W. Braveman, Laurie A. Farrell, George J. Yohrling, Derek P. DiRocco, Caroline L. Benn, Silvia Ginés, Ghazaleh Sadri-Vakili, Kelly E. Glajch, Marcy E. MacDonald, Dimitri Krainc, Alice S. Chen-Plotkin
Publikováno v:
Neurobiology of Disease, Vol 22, Iss 2, Pp 233-241 (2006)
Huntington's disease (HD) is a neurodegenerative disease caused by expansion of a polyglutamine tract within the huntingtin protein. Transcriptional dysregulation has been implicated in HD pathogenesis; recent evidence suggests a defect in Sp1-mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8ee30ff712f57d021bd95d655d33f2
https://doi.org/10.1016/j.nbd.2005.11.001
https://doi.org/10.1016/j.nbd.2005.11.001
Autor:
Susanne V. Fleig, Dirk Heckl, Yoichiro Ikeda, Rafael Kramann, Helmut G. Rennke, Sushrut S. Waikar, Benjamin D. Humphreys, Steven L. Fabian, Steven L. Chang, Janewit Wongboonsin, Rebekka K. Schneider, Derek P. DiRocco, Omar H. Maarouf
Publikováno v:
The Journal of clinical investigation. 125(8)
Chronic kidney disease is characterized by interstitial fibrosis and proliferation of scar-secreting myofibroblasts, ultimately leading to end-stage renal disease. The hedgehog (Hh) pathway transcriptional effectors GLI1 and GLI2 are expressed in myo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e21045f3afe72490aca8f805e08bf2
https://pubmed.ncbi.nlm.nih.gov/26241018
https://pubmed.ncbi.nlm.nih.gov/26241018
Autor:
Zhengui Xia, Derek P. DiRocco
Publikováno v:
Nature Neuroscience. 10:938-940
Pheromones influence sexual behavior and reproduction in rodents. A new report suggests that neurogenesis induced in the female mouse brain by male pheromones governs the choice of dominant males as mates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a56b11b863f229ca7df238b11f34ff0
https://doi.org/10.1038/nn0807-938
https://doi.org/10.1038/nn0807-938