Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Derek P Narendra"'
Autor:
Hsin-Pin Lin, Derek P Narendra
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1226-1227 (2024)
Mitochondria are the powerhouses of the cell, and they are fuel flexible. They can generate power from nearly every abundant carbon source in the body, including carbohydrates, amino acids, and fatty acids. When mitochondria are sick, however, some f
Externí odkaz:
https://doaj.org/article/41ba8bb72d62448f9661bd10c2df2b73
Autor:
Derek P Narendra, Seok Min Jin, Atsushi Tanaka, Der-Fen Suen, Clement A Gautier, Jie Shen, Mark R Cookson, Richard J Youle
Publikováno v:
PLoS Biology, Vol 8, Iss 1, p e1000298 (2010)
Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their autophagy. How Parkin recognizes d
Externí odkaz:
https://doaj.org/article/8e127fc52b86486593b7ee294d8b508c
Autor:
William Zhu, Xiaoping Huang, Esther Yoon, Sara Bandres-Ciga, Cornelis Blauwendraat, Kimberly J Billingsley, Joshua H Cade, Beverly P Wu, Victoria H Williams, Alice B Schindler, Janet Brooks, J Raphael Gibbs, Dena G Hernandez, Debra Ehrlich, Andrew B Singleton, Derek P Narendra
Publikováno v:
Brain
PRKN mutations are the most common recessive cause of Parkinson’s disease and are a promising target for gene and cell replacement therapies. Identification of biallelic PRKN patients at the population scale, however, remains a challenge, as roughl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f628ca7e72e3405b2283a238596ac9eb
https://doi.org/10.1093/brain/awab456
https://doi.org/10.1093/brain/awab456
Autor:
Hsin-Pin Lin, Derek P. Narendra
Publikováno v:
Brain. 145:811-813
This scientific commentary refers to ‘Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state’ by Smajić et al. (https://doi.org/10.1093/brain/awab446).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389bfc1b8d57fa2e82eb796052b0bb69
https://doi.org/10.1093/brain/awac071
https://doi.org/10.1093/brain/awac071
Autor:
Derek P. Narendra, Julia A. Thayer
Publikováno v:
Movement disorders : official journal of the Movement Disorder SocietyReferences. 37(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50335509af5282831d7d0fa5f1adf572
https://pubmed.ncbi.nlm.nih.gov/35460111
https://pubmed.ncbi.nlm.nih.gov/35460111
SummaryThe heme-regulated kinase HRI is activated under heme/iron deficient conditions; however, the underlying molecular mechanism is incompletely understood. Here, we show that iron deficiency-induced HRI activation involves a heme-independent mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c9d3d7285ee3d258a26a307c88be31e
https://doi.org/10.1101/2022.04.14.488327
https://doi.org/10.1101/2022.04.14.488327
Autor:
Mario K Shammas, Beverly P Wu, Shiori Sekine, Diana Nguyen, Joanna Poulton, Derek P. Narendra, Xiaoping Huang, Yi-Ting Liu, Danielle A. Springer, Eszter Dombi
Publikováno v:
Hum Mol Genet
Dominant mutations in the mitochondrial paralogs coiled-helix-coiled-helix (CHCHD) domain 2 (C2) and CHCHD10 (C10) were recently identified as causing Parkinson’s disease and amyotrophic lateral sclerosis/frontotemporal dementia/myopathy, respectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa57d37a8d74955b9d902ce8e77d052
https://doi.org/10.1093/hmg/ddaa077
https://doi.org/10.1093/hmg/ddaa077
Autor:
Mario K. Shammas, Xiaoping Huang, Beverly P. Wu, Evelyn Fessler, Insung Y. Song, Nicholas P. Randolph, Yan Li, Christopher K.E. Bleck, Danielle A. Springer, Carl Fratter, Ines A. Barbosa, Andrew F. Powers, Pedro M. Quirós, Carlos Lopez-Otin, Lucas T. Jae, Joanna Poulton, Derek P. Narendra
Publikováno v:
The Journal of Clinical Investigation
Scopus
Scopus
Mitochondrial stress triggers a response in the cell's mitochondria and nucleus, but how these stress responses are coordinated in vivo is poorly understood. Here, we characterize a family with myopathy caused by a dominant p.G58R mutation in the mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e5f814260bd5833bf04f17cdcafd26
Autor:
Mario K. Shammas, Xiaoping Huang, Beverly P. Wu, Insung Song, Nicholas Randolph, Yan Li, Christopher K. E. Bleck, Danielle A. Springer, Carl Fratter, Ines A. Barbosa, Andrew F. Powers, Pedro M. Quirós, Carlos Lopez-Otin, Joanna Poulton, Derek P. Narendra
Mitochondrial stress triggers a response in the cell’s mitochondria and nucleus, but how these stress responses are coordinated in vivo is poorly understood. Here, we characterize a family with myopathy caused by a dominant p.G58R mutation in the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa7193f7a8255862d65cb36d7304cd88
https://doi.org/10.1101/2021.12.21.473493
https://doi.org/10.1101/2021.12.21.473493
Autor:
Kei Murakami, Stacy G. Wendell, Yusuke Sekine, Shiori Sekine, Steven J. Mullett, Mads Breum Larsen, Bill B. Chen, Derek P. Narendra, Ryan Houston
Publikováno v:
Molecular Biology of the Cell
Mitochondria evolved from endosymbiotic bacteria to become essential organelles of eukaryotic cells. The unique lipid composition and structure of mitochondrial membranes are critical for the proper functioning of mitochondria. However, stress respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398e6eec690c7351f37051064fd7a5b4
https://doi.org/10.1091/mbc.e21-04-0191
https://doi.org/10.1091/mbc.e21-04-0191