Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Derek P Claxton"'
Autor:
Swastik Phulera, Hongtao Zhu, Jie Yu, Derek P Claxton, Nate Yoder, Craig Yoshioka, Eric Gouaux
Publikováno v:
eLife, Vol 7 (2018)
Fast inhibitory neurotransmission in the mammalian nervous system is largely mediated by GABAA receptors, chloride-selective members of the superfamily of pentameric Cys-loop receptors. Native GABAA receptors are heteromeric assemblies sensitive to m
Externí odkaz:
https://doaj.org/article/a92fc16f5f7b442fb41ea394d64de88c
Autor:
Derek P Claxton, Eric Gouaux
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0201210 (2018)
The GABA-gated chloride channels of the Cys-loop receptor family, known as GABAA receptors, function as the primary gatekeepers of fast inhibitory neurotransmission in the central nervous system. Formed by the pentameric arrangement of five identical
Externí odkaz:
https://doaj.org/article/0f3bf90c3ca743858355a8dfbbf8f960
Autor:
Matt Sinclair, Richard A Stein, Jonathan H Sheehan, Emily M Hawes, Richard M O’Brien, Emad Tajkhorshid, Derek P Claxton
Publikováno v:
bioRxiv
Mediating the terminal reaction of gluconeogenesis and glycogenolysis, the integral membrane protein G6PC1 regulates hepatic glucose production by catalyzing hydrolysis of glucose-6-phosphate within the lumen of the endoplasmic reticulum. Because G6P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e1ab1687e29263a064bcb2b88f9982
https://doi.org/10.1101/2023.03.13.532485
https://doi.org/10.1101/2023.03.13.532485
Publikováno v:
Biophysical Journal. 122:185a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f113cef71ea2bc9089c1075351297f5
https://doi.org/10.1016/j.bpj.2022.11.1141
https://doi.org/10.1016/j.bpj.2022.11.1141
Publikováno v:
The Journal of Biological Chemistry
Glucose-6-phosphatase catalytic subunit 1 (G6PC1) plays a critical role in hepatic glucose production during fasting by mediating the terminal step of the gluconeogenesis and glycogenolysis pathways. In concert with accessory transport proteins, this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45301e5d4c36927c685c3789bb80f088
http://europepmc.org/articles/PMC8753184
http://europepmc.org/articles/PMC8753184
Publikováno v:
J Biol Chem
As a contributor to multidrug resistance, the family of multidrug and toxin extrusion (MATE) transporters couples the efflux of chemically dissimilar compounds to electrochemical ion gradients. Although divergent transport mechanisms have been propos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469972e80a1dcf6efdaf6cf1f753b088
https://doi.org/10.1074/jbc.ra119.009195
https://doi.org/10.1074/jbc.ra119.009195
Autor:
Emel Ficici, José D. Faraldo-Gómez, Robyn Stix, Hassane S. Mchaourab, Osamu Nureki, Derek P. Claxton, Steven Castellano, Wenchang Zhou, Tsukasa Kusakizako
Publikováno v:
The Journal of Biological Chemistry
In both prokaryotes and eukaryotes, multidrug and toxic-compound extrusion (MATE) transporters catalyze the efflux of a broad range of cytotoxic compounds, including human-made antibiotics and anticancer drugs. MATEs are secondary-active antiporters,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669cc8f65e9478a69f98f57e59ddbe7a
https://pubmed.ncbi.nlm.nih.gov/33402425
https://pubmed.ncbi.nlm.nih.gov/33402425
Autor:
Jessica L. Hanks, Bing Han, Kelly A. Dryden, Hassane S. Mchaourab, Anne K. Kenworthy, Elad Binshtein, Derek P. Claxton, Erkan Karakas, Melanie D. Ohi, Jason C. Porta, Yelena Peskova
Publikováno v:
Science Advances
Single particle analysis reveals how the membrane sculpting protein caveolin 1 is packaged within disc-shaped complexes.
Highly stable oligomeric complexes of the monotopic membrane protein caveolin serve as fundamental building blocks of caveol
Highly stable oligomeric complexes of the monotopic membrane protein caveolin serve as fundamental building blocks of caveol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c999db21c98cdcf6b371f9c024aa519
http://europepmc.org/articles/PMC7821874
http://europepmc.org/articles/PMC7821874
Autor:
Emily M. Overway, Karin J. Bosma, Derek P. Claxton, James K. Oeser, Kritika Singh, Lindsay B. Breidenbach, Hassane S. Mchaourab, Lea K. Davis, Richard M. O'Brien
Publikováno v:
The Journal of Biological Chemistry
G6PC2 encodes a glucose-6-phosphatase (G6Pase) catalytic subunit that modulates the sensitivity of insulin secretion to glucose and thereby regulates fasting blood glucose (FBG). A common single-nucleotide polymorphism (SNP) in G6PC2, rs560887 is an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef4340dded8a0d34baa547e94588b64
https://doi.org/10.1016/j.jbc.2021.101534
https://doi.org/10.1016/j.jbc.2021.101534
Publikováno v:
J Mol Biol
The multidrug and toxin extrusion (MATE) transporters catalyze active efflux of a broad range of chemically- and structurally-diverse compounds including antimicrobials and chemotherapeutics, thus contributing to multidrug resistance in pathogenic ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95681a07b76af3ed6b7196ec37ab35e9
https://doi.org/10.1016/j.jmb.2021.166959
https://doi.org/10.1016/j.jmb.2021.166959