Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Derek N Macklin"'
Autor:
David A Van Valen, Takamasa Kudo, Keara M Lane, Derek N Macklin, Nicolas T Quach, Mialy M DeFelice, Inbal Maayan, Yu Tanouchi, Euan A Ashley, Markus W Covert
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 11, p e1005177 (2016)
Live-cell imaging has opened an exciting window into the role cellular heterogeneity plays in dynamic, living systems. A major critical challenge for this class of experiments is the problem of image segmentation, or determining which parts of a micr
Externí odkaz:
https://doaj.org/article/fbd13d77eb8040efa67c729bc11bb083
Publikováno v:
Molecular Systems Biology, Vol 8, Iss 1, Pp 1-13 (2012)
Abstract Viral infection depends on a complex interplay between host and viral factors. Here, we link host susceptibility to viral infection to a network encompassing sulfur metabolism, tRNA modification, competitive binding, and programmed ribosomal
Externí odkaz:
https://doaj.org/article/cfe3cb5670c24b3cbd0dfb770a5c8ba3
Autor:
Tanja Woyke, Daniel Barich, Joan L. Slonczewski, Rob Egan, Volkan Sevim, Dongwan D. Kang, Derek N. Macklin, Rachael M. Morgan-Kiss, Jeff Froula, Harrison Ho, Frederik Schulz, Wei Li, Zhong Wang, Kayla McCue, Shijie Yao, Rachel Orsini, Christopher J. Sedlacek, Jackie E. Shay
Classifying taxa, including those that have not previously been identified, is a key task in characterizing the microbial communities of under-described habitats, including permanently ice-covered lakes in the dry valleys of the Antarctic. Current su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033506eb5ab89f18b15a66df268b54c6
Autor:
Peter D. Karp, Inbal Maayan, Gwanggyu Sun, Sajia Akhter, Taryn E. Gillies, Daniel Weaver, Heejo Choi, Jerry H. Morrison, Samuel R. Bray, Ingrid M. Keseler, Morgan L. Paull, Ryan K. Spangler, Travis A. Ahn-Horst, Markus W. Covert, Nicholas A. Ruggero, Mialy M. DeFelice, John C. Mason, Javier Carrera, Derek N. Macklin, Keara Michelle Lane, Eran Agmon
Publikováno v:
Science. 369:eaav3751
The extensive heterogeneity of biological data poses challenges to analysis and interpretation. Construction of a large-scale mechanistic model of Escherichia coli enabled us to integrate and cross-evaluate a massive, heterogeneous dataset based on m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94b08b6985d35dcd7c31c99e05c62ffb
https://doi.org/10.1126/science.aav3751
https://doi.org/10.1126/science.aav3751
Autor:
Derek N, Macklin, Travis A, Ahn-Horst, Heejo, Choi, Nicholas A, Ruggero, Javier, Carrera, John C, Mason, Gwanggyu, Sun, Eran, Agmon, Mialy M, DeFelice, Inbal, Maayan, Keara, Lane, Ryan K, Spangler, Taryn E, Gillies, Morgan L, Paull, Sajia, Akhter, Samuel R, Bray, Daniel S, Weaver, Ingrid M, Keseler, Peter D, Karp, Jerry H, Morrison, Markus W, Covert
Publikováno v:
Science (New York, N.Y.). 369(6502)
The extensive heterogeneity of biological data poses challenges to analysis and interpretation. Construction of a large-scale mechanistic model of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9276b425197d6724fbd306f575e1a3a3
https://pubmed.ncbi.nlm.nih.gov/32994565
https://pubmed.ncbi.nlm.nih.gov/32994565
Autor:
Derek N. Macklin, Jacob J. Hughey, Sajia Akhter, Markus W. Covert, Takamasa Kudo, Sergi Regot, Stevan Jeknić
Publikováno v:
Nature protocols. 13(1)
Although kinases are important regulators of many cellular processes, measuring their activity in live cells remains challenging. We have developed kinase translocation reporters (KTRs), which enable multiplexed measurements of the dynamics of kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1f26a000279daa0a359ed34ee6dae9
https://pubmed.ncbi.nlm.nih.gov/29266096
https://pubmed.ncbi.nlm.nih.gov/29266096
Autor:
Keara Michelle Lane, Derek N. Macklin, Ambrose J. Carr, Dana Pe'er, David Van Valen, Takamasa Kudo, Ariel Jaimovich, Mialy M. DeFelice, Markus W. Covert, Stéphane C. Boutet, Tobias Meyer
Signaling proteins display remarkable cell-to-cell heterogeneity in their dynamic responses to stimuli, but the consequences of this heterogeneity remain largely unknown. For instance, the contribution of the dynamics of the innate immune transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13596dab7d50f897dbbaf1ec183ddd50
https://resolver.caltech.edu/CaltechAUTHORS:20180613-110240953
https://resolver.caltech.edu/CaltechAUTHORS:20180613-110240953
Autor:
Nicolas Quach, Markus W. Covert, Takamasa Kudo, David Van Valen, Inbal Maayan, Euan A. Ashley, Keara Michelle Lane, Yu Tanouchi, Derek N. Macklin, Mialy M. DeFelice
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 12, Iss 11, p e1005177 (2016)
PLoS Computational Biology, Vol 12, Iss 11, p e1005177 (2016)
Live-cell imaging has opened an exciting window into the role cellular heterogeneity plays in dynamic, living systems. A major critical challenge for this class of experiments is the problem of image segmentation, or determining which parts of a micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02940319140d5518d17fa351a799ce5d
https://pubmed.ncbi.nlm.nih.gov/27814364
https://pubmed.ncbi.nlm.nih.gov/27814364
Publikováno v:
Nucleic Acids Research
Whole-cell models promise to greatly facilitate the analysis of complex biological behaviors. Whole-cell model development requires comprehensive model organism databases. WholeCellKB (http://wholecellkb.stanford.edu) is an open-source web-based soft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9c40b3c1388de9c41679065a2aa993
http://europepmc.org/articles/PMC3531061
http://europepmc.org/articles/PMC3531061
Publikováno v:
Current opinion in biotechnology. 28
Integrated whole-cell modeling is poised to make a dramatic impact on molecular and systems biology, bioengineering, and medicine--once certain obstacles are overcome. From our group's experience building a whole-cell model of Mycoplasma genitalium,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3dfe15c023f117e9e7d6e09889eeefa
https://pubmed.ncbi.nlm.nih.gov/24556244
https://pubmed.ncbi.nlm.nih.gov/24556244