Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Derek Macmillan"'
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166268 (2016)
Tissue kallikreins (KLKs), in particular KLK5, 7 and 14 are the major serine proteases in the skin responsible for skin shedding and activation of inflammatory cell signaling. In the normal skin, their activities are controlled by an endogenous prote
Externí odkaz:
https://doaj.org/article/41b6d02ba7dd4ecbb081e4896f766707
Autor:
Silke M Currie, Emily Gwyer Findlay, Brian J McHugh, Annie Mackellar, Tian Man, Derek Macmillan, Hongwei Wang, Paul M Fitch, Jürgen Schwarze, Donald J Davidson
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e73659 (2013)
Respiratory syncytial virus is a leading cause of lower respiratory tract illness among infants, the elderly and immunocompromised individuals. Currently, there is no effective vaccine or disease modifying treatment available and novel interventions
Externí odkaz:
https://doaj.org/article/6bc4431fc09a4e508c8c07a5dfaab2b8
Publikováno v:
Organic & Biomolecular Chemistry. 20:8506-8514
Homogeneous glycoprotein syntheses have become possible in the last decade due to advances in chemical ligation strategies, particularly Native Chemical Ligation (NCL). For native glycoproteins this still requires laborious and technically challengin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4411f079990b86151b5a2e36dd566786
https://doi.org/10.1039/d2ob01633h
https://doi.org/10.1039/d2ob01633h
Publikováno v:
Organicbiomolecular chemistry. 20(36)
Here we explore electrochemical dethiylation in processes relevant to Native Chemical Ligation (NCL). NCL's reliance on the redox active amino acid cysteine and β-mercaptamine derivatives suggests a potential role for electrochemistry. We show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d524a85a3fd73407d96d194ba2f5c358
https://pubmed.ncbi.nlm.nih.gov/36073340
https://pubmed.ncbi.nlm.nih.gov/36073340
Publikováno v:
Chemical Communications. 57:1006-1009
Head-to-sidechain macrocylic peptides, and neoglycopeptides, were readily prepared by site-specific amidation of aspartic and glutamic acid sidechain hydrazides. Hydrazides, serving as latent thioesters, were introduced through regioselective opening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d592064db282a4cfd75510ca39a56e
https://doi.org/10.1039/d0cc07404g
https://doi.org/10.1039/d0cc07404g
Publikováno v:
Transition Metal Chemistry. 43:421-430
Microwave irradiation of 1,6-diynes, RC≡C(CH2)4C≡CR, with Fe(CO)5 in dimethylether leads to the facile and clean formation of cyclopentadienone complexes [{η4-C4R2C(O)C4H8}Fe(CO)3] in good yields resulting from a [2 + 2 + 1] cycloaddition. The m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0155dc237ca52be41906cdcbd0a6c0da
https://doi.org/10.1007/s11243-018-0229-1
https://doi.org/10.1007/s11243-018-0229-1
Publikováno v:
Synlett. 29:314-317
Herein we report the first synthesis of protected boronocysteine. The target compound was prepared via copper-catalysed diastereoselective nucleophilic borylation of a sulfinimine. After deprotection to give the amine as the hydrochloride salt, four
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81f7b70a729409042affb7030388d834
https://doi.org/10.1055/s-0036-1591491
https://doi.org/10.1055/s-0036-1591491
Autor:
Derek Macmillan
Publikováno v:
Synlett. 28:1517-1529
It is not highly sophisticated, yet the N→S acyl transfer reaction of a native peptide sequence potentially fills an important technology gap. While several routes to synthetic peptide thioesters exist, only one is routinely applicable for biologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27f1636c2a105fa483942100c06d4938
https://doi.org/10.1055/s-0036-1588789
https://doi.org/10.1055/s-0036-1588789
Publikováno v:
Organic & Biomolecular Chemistry. 13:7469-7476
Understanding the factors that influence N → S acyl transfer in native peptide sequences, and discovery of new reagents that facilitate it, will be key to expanding its scope and applicability. Here, through a study of short model peptides in thioe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a58776660fc637e0366808de27f7c1
https://doi.org/10.1039/c5ob01029b
https://doi.org/10.1039/c5ob01029b
Autor:
Wei-Li Di, Ryan F.L. O'Shaughnessy, Leila Shariff, Yanan Zhu, Peter S. Friedmann, Derek Macmillan, Chris Pickard, John I. Harper, Joanne Underwood, Eugene Healy
Background Upregulation of kallikreins (KLKs) including KLK5 has been reported in atopic dermatitis (AD). KLK5 has biological functions that include degrading desmosomal proteins and inducing proinflammatory cytokine secretion through protease-activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc359ac9fc0d0eb90d2254ed587dbf6
https://eprints.soton.ac.uk/409612/
https://eprints.soton.ac.uk/409612/
