Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Derek M. Kendig"'
Autor:
Sunila Mahavadi, Ancy D Nalli, Hongxia Wang, Derek M Kendig, Molly S Crowe, Vijay Lyall, John R Grider, Karnam S Murthy
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209359 (2018)
In gastrointestinal smooth muscle, acetylcholine induced muscle contraction is biphasic, initial peak followed by sustained contraction. Contraction is regulated by phosphorylation of 20 kDa myosin light chain (MLC) at Ser19, interaction of actin and
Externí odkaz:
https://doaj.org/article/a065e35dc5334bd181409ec4303e296e
Publikováno v:
Frontiers in Pharmacology, Vol 2 (2012)
Contraction of bladder smooth muscle is predominantly initiated by M3 muscarinic receptor-mediated activation of the Gq/11-phospholipase C β-protein kinase C (PKC) and the G12/13-RhoGEF-Rho kinase (ROCK) pathways. However, these pathways and their d
Externí odkaz:
https://doaj.org/article/a6db58d19a044009a600e6cdfb6b64a7
Autor:
John R. Grider, Hongxia Wang, Sunila Mahavadi, Molly S. Crowe, Derek M. Kendig, Ancy D. Nalli, Karnam S. Murthy, Vijay Lyall
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 12, p e0209359 (2018)
PLoS ONE, Vol 13, Iss 12, p e0209359 (2018)
In gastrointestinal smooth muscle, acetylcholine induced muscle contraction is biphasic, initial peak followed by sustained contraction. Contraction is regulated by phosphorylation of 20 kDa myosin light chain (MLC) at Ser19, interaction of actin and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089a1cd50a155f64c44ba0834bbb4af0
https://pubmed.ncbi.nlm.nih.gov/31697794
https://pubmed.ncbi.nlm.nih.gov/31697794
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05917ba837675f4e7f626728ea64fbd1
https://doi.org/10.1096/fasebj.2018.32.1_supplement.764.4
https://doi.org/10.1096/fasebj.2018.32.1_supplement.764.4
Autor:
John R. Grider, Karnam S. Murthy, Charles D. Anderson, Derek M. Kendig, Mohammad Alqudah, Sunila Mahavadi
Publikováno v:
Journal of Smooth Muscle Research
The longitudinal muscle layer in gut is the functional opponent to the circular muscle layer during peristalsis. Differences in innervation of the layers allow for the contraction of one layer concurrently with the relaxation of the other, enabling t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f4632d95151b18d490400591362b92b
http://europepmc.org/articles/PMC4862207
http://europepmc.org/articles/PMC4862207
Autor:
Karnam S. Murthy, Derek M. Kendig, Hongxia Wang, John R. Grider, Sayak Bhattacharya, Ancy D. Nalli
Hydrogen sulfide (H2S), like nitric oxide (NO), causes smooth muscle relaxation, but unlike NO, does not stimulate soluble guanylyl cyclase (sGC) activity and generate cyclic guanosine 5′-monophosphate (cGMP). The aim of this study was to investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f901c60c75a8a41e316447d931c21de6
https://europepmc.org/articles/PMC5668569/
https://europepmc.org/articles/PMC5668569/
Autor:
Sunila Mahavadi, John R. Grider, John A. DeSimone, Vijay Lyall, Norman Hurst, Zachary L. Bradley, John F. Kuemmerle, Derek M. Kendig, Karnam S. Murthy
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 307:G1100-G1107
Intraluminal nutrients in the gut affect the peristaltic reflex, although the mechanism is not well defined. Recent evidence supports the presence of taste receptors and their signaling components in enteroendocrine cells, although their function is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d8ddb71e11a9406e3b0b7ddc63a773
https://doi.org/10.1152/ajpgi.00251.2014
https://doi.org/10.1152/ajpgi.00251.2014
Publikováno v:
European Journal of Pharmacology. 720:355-362
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that contracts most smooth muscles. Although S1P has been shown to contract bladder smooth muscle, the mechanism(s) by which S1P initiates contraction has not been extensively investigated. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18817fa37330e585594d88974523945d
https://doi.org/10.1016/j.ejphar.2013.10.004
https://doi.org/10.1016/j.ejphar.2013.10.004
Type II diabetes is the most prevalent form of diabetes. One of the primary complications of diabetes that significantly affects quality of life is bladder dysfunction. Many studies on diabetic bladder dysfunction have been performed in models of typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48720f2b9934715ab4430c702caf1a1
https://europepmc.org/articles/PMC4867315/
https://europepmc.org/articles/PMC4867315/
Publikováno v:
Journal of Visualized Experiments.
Multiple approaches have been used to record and evaluate gastrointestinal motility including: recording changes in muscle tension, intraluminal pressure, and membrane potential. All of these approaches depend on measurement of activity at one or mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f46c7a5797cd189235dd235b9ea5af54
https://doi.org/10.3791/53263
https://doi.org/10.3791/53263