Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Derek Liqiang Tou"'
Autor:
Paul E. Fleming, James M. Gavin, Yu Yang, Marc Hyer, Petter Veiby, Michael Milhollen, Peter G. Smith, Tary Traore, Sai M. Pulukuri, Jeff Ciavarri, Mark Manfredi, Darshan S. Sappal, Neil Bence, James E. Brownell, Kara Hoar, Jessica Huck, Christopher F. Claiborne, Lawrence Dick, Derek Liqiang Tou
Publikováno v:
Molecular Cancer Therapeutics. 10:C82-C82
Millennium Pharmaceuticals, Inc. is dedicated to the discovery and development of novel oncology therapeutics in the area of protein homeostasis. Here we report the identification and characterization of compounds that target the ubiquitin activating
Autor:
Sai M. Pulukuri, Derek Liqiang Tou, Allison Berger, Lilli Petruzzelli, Peter G. Smith, Mark Manfredi, Michael D. Pickard, Tary Traore
Publikováno v:
Molecular Cancer Therapeutics. 8:B189-B189
MLN4924 is a novel, small molecule inhibitor of Nedd8-activating enzyme (NAE) that is currently in Phase I clinical trials in hematologic malignancies. We have previously described the pre-clinical anti-tumor activity of MLN4924 in human xenograft mo