Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Derek Law"'
In Vitro Activity of the Novel Antifungal Olorofim against Scedosporium and Lomentospora prolificans
Autor:
Ourania Georgacopoulos, Natalie Nunnally, Derek Law, Mike Birch, Elizabeth L. Berkow, Shawn R. Lockhart
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT Scedosporium spp. and Lomentospora prolificans are an emerging group of fungi refractory to current antifungal treatments. These species largely affect immunocompromised individuals but can also be lung colonizers in cystic fibrosis patients
Externí odkaz:
https://doaj.org/article/e2deccf6e4c34d04bee4cce4d60d38f8
Autor:
Jochem B. Buil, Jason D. Oliver, Derek Law, Tim Baltussen, Jan Zoll, Margriet W.J. Hokken, Marlou Tehupeiory-Kooreman, Willem J.G. Melchers, Mike Birch, Paul E. Verweij
Publikováno v:
Emerging Microbes and Infections, Vol 0, Iss 0, Pp 1-33 (2022)
Olorofim (F901318) is a new antifungal currently under clinical development that shows both in vitro and in vivo activity against a number of filamentous fungi including Aspergillus fumigatus. In this study we screened A. fumigatus isolates for intri
Externí odkaz:
https://doaj.org/article/f97bff74450343ecbd73017cc0e4383d
Autor:
Ourania Georgacopoulos, Natalie S. Nunnally, Eric M. Ransom, Derek Law, Mike Birch, Shawn R. Lockhart, Elizabeth L. Berkow
Publikováno v:
Journal of Fungi, Vol 7, Iss 5, p 378 (2021)
Olorofim is a novel antifungal drug that belongs to the orotomide drug class which inhibits fungal dihydroorotate dehydrogenase (DHODH), thus halting pyrimidine biosynthesis and ultimately DNA synthesis, cell growth and division. It is being develope
Externí odkaz:
https://doaj.org/article/356ca938388c4e69a7c33add6501103f
Autor:
Saskia du Pré, Mike Birch, Derek Law, Nicola Beckmann, Graham E. M. Sibley, Michael J. Bromley, Nick D. Read, Jason D. Oliver
Publikováno v:
Journal of Fungi, Vol 6, Iss 2, p 47 (2020)
The first characterized antifungal in the orotomide class is olorofim. It targets the de novo pyrimidine biosynthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH). The pyrimidines uracil, thymine and cytosine are the building blocks of
Externí odkaz:
https://doaj.org/article/aa407e5c7ed14ec7a7370f2aaa5ab714
Autor:
William W. Hope, Laura McEntee, Joanne Livermore, Sarah Whalley, Adam Johnson, Nicola Farrington, Ruwanthi Kolamunnage-Dona, Julie Schwartz, Anthony Kennedy, Derek Law, Michael Birch, John H. Rex
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT F901318 is an antifungal agent with a novel mechanism of action and potent activity against Aspergillus spp. An understanding of the pharmacodynamics (PD) of F901318 is required for selection of effective regimens for study in phase II and I
Externí odkaz:
https://doaj.org/article/ee5b4c0c99644111aad9e0e94bbbb141
Autor:
Derek Law, Seamus Ross
Publikováno v:
Liber Quarterly: The Journal of European Research Libraries, Vol 26, Iss 4 (2017)
Externí odkaz:
https://doaj.org/article/94f33ebd000e4960ae585c6935e4e496
Autor:
Derek Law
Publikováno v:
Liber Quarterly: The Journal of European Research Libraries, Vol 24, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/e213921d16b84c5691e2c7b2c3e5e060
Publikováno v:
Research in Learning Technology, Vol 11, Iss 1 (2003)
Peter Jarvis is Professor of Continuing Education at the University of Surrey and a distinguished authority in this field. In this work he attempts to analyse what constitutes a 'real university' and whether the social changes which have impacted on
Externí odkaz:
https://doaj.org/article/01ad7dc9045c45e8937d27bf8696fdb0
Autor:
Jochem B, Buil, Jason D, Oliver, Derek, Law, Tim, Baltussen, Jan, Zoll, Margriet W J, Hokken, Marlou, Tehupeiory-Kooreman, Willem J G, Melchers, Mike, Birch, Paul E, Verweij
Publikováno v:
Emerging microbesinfections. 11(1)
Olorofim (F901318) is a new antifungal currently under clinical development that shows both
Autor:
Derek Law, Jochem Berend Buil, Paul E. Verweij, Marlou C Tehupeiory-Kooreman, Mike Birch, Tim J. H. Baltussen, Willem J. G. Melchers, Jason David Oliver, Jan Zoll, Margriet W.J. Hokken
Publikováno v:
Emerging Microbes and Infections, 11, 1, pp. 703-714
Emerging Microbes and Infections, 11, 703-714
Emerging Microbes and Infections, Vol 0, Iss 0, Pp 1-33 (2022)
Emerging Microbes and Infections, 11, 703-714
Emerging Microbes and Infections, Vol 0, Iss 0, Pp 1-33 (2022)
Olorofim (F901318) is a new antifungal currently under clinical development that shows both in vitro and in vivo activity against a number of filamentous fungi including Aspergillus fumigatus. In this study we screened A. fumigatus isolates for intri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4ed5cf05eefbc44f1f5d25a8b9252c