Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Derek L. Stirewalt"'
Autor:
Marie Bleakley, Ralph Graeme Black, David Wu, Melinda Ann Biernacki, Jessica Lok, Kimberly A Foster, Carrie Cummings, Kyle B Woodward, Tim Monahan, Vivian G Oehler, Derek L Stirewalt, Anthony Rongvaux, Hans Joachim Deeg
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 12 (2023)
Background Myelodysplastic syndromes (MDS) arise from somatic mutations acquired in hematopoietic stem and progenitor cells, causing cytopenias and predisposing to transformation into secondary acute myeloid leukemia (sAML). Recurrent mutations in sp
Externí odkaz:
https://doaj.org/article/f4118942bcee4419aa80630b09b59a98
Autor:
Era L. Pogosova-Agadjanyan, Xing Hua, Megan Othus, Frederick R. Appelbaum, Thomas R. Chauncey, Harry P. Erba, Matthew P. Fitzgibbon, Isaac C. Jenkins, Min Fang, Stanley C. Lee, Anna Moseley, Jasmine Naru, Jerald P. Radich, Jenny L. Smith, Brooke E. Willborg, Cheryl L. Willman, Feinan Wu, Soheil Meshinchi, Derek L. Stirewalt
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Background Studies have not systematically compared the ability to verify performance of prognostic transcripts in paired bulk mononuclear cells versus viable CD34-expressing leukemic blasts from patients with acute myeloid leukemia. We hypo
Externí odkaz:
https://doaj.org/article/068af1ff03784be8bc61228665d49697
Autor:
Christina M. Termini, Anna Moseley, Megan Othus, Frederick R. Appelbaum, Thomas R. Chauncey, Harry P. Erba, Min Fang, Stanley C. Lee, Jasmine Naru, Era L. Pogosova-Agadjanyan, Jerald P. Radich, Cheryl L. Willman, Feinan Wu, Soheil Meshinchi, Derek L. Stirewalt
Publikováno v:
Haematologica, Vol 108, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/4c2f1cc13a4d4e82997fde8282f05c18
Autor:
Era L. Pogosova-Agadjanyan, Anna Moseley, Megan Othus, Frederick R. Appelbaum, Thomas R. Chauncey, I-Ming L. Chen, Harry P. Erba, John E. Godwin, Isaac C. Jenkins, Min Fang, Mike Huynh, Kenneth J. Kopecky, Alan F. List, Jasmine Naru, Jerald P. Radich, Emily Stevens, Brooke E. Willborg, Cheryl L. Willman, Brent L. Wood, Qing Zhang, Soheil Meshinchi, Derek L. Stirewalt
Publikováno v:
Biomarker Research, Vol 8, Iss 1, Pp 1-13 (2020)
Abstract Background The recently updated European LeukemiaNet risk stratification guidelines combine cytogenetic abnormalities and genetic mutations to provide the means to triage patients with acute myeloid leukemia for optimal therapies. Despite th
Externí odkaz:
https://doaj.org/article/066cab4547fe4d0eae3f37a2fba497cb
Autor:
Jason E. Farrar, Jenny L. Smith, Megan Othus, Benjamin J. Huang, Yi-Cheng Wang, Rhonda Ries, Tiffany Hylkema, Era L. Pogosova-Agadjanyan, Sneha Challa, Amanda Leonti, Timothy I. Shaw, Timothy J. Triche, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Xiaotu Ma, Derek L. Stirewalt, Todd A. Alonzo, Soheil Meshinchi
Publikováno v:
Journal of Clinical Oncology. 41:2949-2962
PURPOSE Optimized strategies for risk classification are essential to tailor therapy for patients with biologically distinctive disease. Risk classification in pediatric acute myeloid leukemia (pAML) relies on detection of translocations and gene mut
Autor:
Miranda C. Lahman, Thomas M. Schmitt, Kelly G. Paulson, Nathalie Vigneron, Denise Buenrostro, Felecia D. Wagener, Valentin Voillet, Lauren Martin, Raphael Gottardo, Jason Bielas, Julie M. McElrath, Derek L. Stirewalt, Era L. Pogosova-Agadjanyan, Cecilia C. Yeung, Robert H. Pierce, Daniel N. Egan, Merav Bar, Paul C. Hendrie, Sinéad Kinsella, Aesha Vakil, Jonah Butler, Mary Chaffee, Jonathan Linton, Megan S. McAfee, Daniel S. Hunter, Marie Bleakley, Anthony Rongvaux, Benoit J. Van den Eynde, Aude G. Chapuis, Philip D. Greenberg
Publikováno v:
Sci Transl Med
Science translational medicine, Vol. 14, no.631, p. eabg8070 (2022)
Science translational medicine, Vol. 14, no.631, p. eabg8070 (2022)
Designing effective antileukemic immunotherapy will require understanding mechanisms underlying tumor control or resistance. Here, we report a mechanism of escape from immunologic targeting in an acute myeloid leukemia (AML) patient, who relapsed 1 y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ab8910054866ad4b7f3c2247308f44
https://doi.org/10.1126/scitranslmed.abg8070
https://doi.org/10.1126/scitranslmed.abg8070
Autor:
Robert K. Bradley, Patrick Nugent, Khrystyna North, Jasmine Naru, Eunhee Kim, Janine O. Ilagan, Joseph Pangallo, Sergei Doulatov, Martina Sarchi, Derek L. Stirewalt, Arvind R. Subramaniam, Rochelle Bergantinos, Massiel Chavez Stolla, Omar Abdel-Wahab, Janis L. Abkowitz, Courtnee Clough
Publikováno v:
Blood. 139:2038-2049
SF3B1 splicing factor mutations are near-universally found in myelodysplastic syndromes (MDS) with ring sideroblasts (RS), a clonal hematopoietic disorder characterized by abnormal erythroid cells with iron-loaded mitochondria. Despite this remarkabl
Autor:
Dang Hai Nguyen, Sayantani Sinha, Zhiyan Silvia Liu, Maxwell Henry Bannister, Erica Arriaga-Gomez, Axia Song, Dawei Zong, Martina Sarchi, Victor Corral, Wannasiri Chiraphapphaiboon, Jennifer Yoo, Matthew McMahon, Cassandra Leibson, Derek L. Stirewalt, H Joachim Deeg, Sumit Rai, Matthew Walter, Timothy A. Graubert, Sergei Doulatov, Stanley C. Lee
Publikováno v:
Cancer Research. 83:6183-6183
Somatic heterozygous mutations in genes encoding for RNA splicing factors (SF) SRSF2, U2AF1, and SF3B1 are frequently mutated in patients with hematologic malignancies, representing a unique genetic vulnerability for targeted therapy. In the current
Autor:
Marcia M. Russell, Mina S. Sedrak, Dominic Moon, Giby V. George, Genevieve Hollis, Martine Extermann, Fareeha Siddiqui, Sumi Misra, Amy L. Stella, Katherine Clifton, Ishwaria Mohan Subbiah, Louise C. Walter, William P. Tew, Liz Hollinger, Elizabeth R. Kessler, Reshma Jagsi, Grant R. Williams, Thuy T. Koll, Ilene S. Browner, Derek L. Stirewalt, Beatriz Korc-Grodzicki, Harvey J. Cohen, Sumati Gupta, Efrat Dotan, Cynthia Owusu, Hema Sundar, June M. McKoy, Joleen M. Hubbard, Ashley E. Rosko, Nancy L. Keating, Tracey O'Connor, Cary P. Gross
Publikováno v:
Journal of the National Comprehensive Cancer Network. 19:1006-1019
The NCCN Guidelines for Older Adult Oncology address specific issues related to the management of cancer in older adults, including screening and comprehensive geriatric assessment (CGA), assessing the risks and benefits of treatment, preventing or d
Autor:
Elihu H. Estey, Guillermo Garcia-Manero, Derek L. Stirewalt, Frederick R. Appelbaum, Megan Othus, John Godwin, James K. Weick, Harry P. Erba
Publikováno v:
Leuk Lymphoma
Among acute myeloid leukemia (AML) patients treated with 7 + 3 induction, we evaluate the association between complete morphologic remission (CR) and long-term overall survival (OS) over four decades. We analyzed 1247 patients age ≤ 65 randomized t