Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Derek L. Dai"'
Autor:
Joel Montane, Merce Obach, Sigrid Alvarez, Loraine Bischoff, Derek L. Dai, Galina Soukhatcheva, John J. Priatel, Gijs Hardenberg, Megan K. Levings, Rusung Tan, Paul C. Orban, C. Bruce Verchere
Publikováno v:
Cell Transplantation, Vol 24 (2015)
Manipulation of regulatory T cell (Treg) migration by islet expression of the chemokine CCL22 prevents diabetes in NOD mice and delays recurrent autoimmunity in syngeneic islet transplants. We sought to determine whether attracting Tregs with CCL22 a
Externí odkaz:
https://doaj.org/article/2df1da3200ad49e49210a10cfb405d07
Supplementary Table 1 from Prognostic Significance of Nuclear Factor-κB p105/p50 in Human Melanoma and Its Role in Cell Migration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc48c46a5531ec545973edb5bc6c5e5
https://doi.org/10.1158/0008-5472.22365198.v1
https://doi.org/10.1158/0008-5472.22365198.v1
Transcriptional factor nuclear factor-κB (NF-κB) family has been shown to play an important role in tumor pathogenesis and serve as a potential target in cancer therapy. However, it is necessary to clarify the specific functions of NF-κB members,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1f51fc1c49d10c97c9907e095f6626
https://doi.org/10.1158/0008-5472.c.6494574.v1
https://doi.org/10.1158/0008-5472.c.6494574.v1
Autor:
Nazde Edeer, C. B. Verchere, Jessica K. Fox, Timothy J. Kieffer, Adam Ramzy, Sarah L. Gray, Maria M. Glavas, James D. Johnson, Derek L. Dai, Robert K. Baker, Shannon O'Dwyer, Xiaoke Hu, Majid Mojibian, Eva Tudurí, Heather C. Denroche
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
In vivo genetic manipulation is used to study the impact of gene deletion or re-expression on β-cell function and organism physiology. Cre-LoxP is a system wherein LoxP sites flanking a gene are recognized by Cre recombinase. Cre transgenic mice are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40d7925c5badbaa5085c2f664e05028
http://link.springer.com/article/10.1038/s41598-020-67136-w
http://link.springer.com/article/10.1038/s41598-020-67136-w
Autor:
Abraham S. Meijnikman, Maaike Winkelmeijer, C. Bruce Verchere, Martin Stahl, Mark Davids, Olivier R. Busch, Hongbing Yu, Galina Soukhatcheva, Willem M. de Vos, Hilde Herrema, Bert-Jan H. van den Born, Max Nieuwdorp, Maurits de Brauw, Marc G. Besselink, Derek L. Dai, Manon Balvers, Stefan R. Havik, Caixia Ma, Ömrüm Aydin, Clara Belzer, Bruce A. Vallance, Torsten P. M. Scheithauer, Guido J. Bakker, Daniël H. van Raalte, Arnold W. J. M. van de Laar
ObjectiveHyperglycemia and type 2 diabetes (T2D) are caused by failure of pancreatic beta cells. The role of the gut microbiota in T2D has been studied but causal links remain enigmatic.DesignObese individuals with or without T2D were included from t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32d97da00ab7dfb5f1b4720a0262f50f
https://doi.org/10.1101/2021.10.07.463317
https://doi.org/10.1101/2021.10.07.463317
Autor:
John J. Priatel, C. Bruce Verchere, Galina Soukhatcheva, Mercè Obach, Derek L. Dai, Azadeh Hosseini-Tabatabaei, Joel Montane, Paul C. Orban, Katarina Wind
Publikováno v:
Molecular and Cellular Endocrinology. 477:48-56
Overexpression of the X-linked inhibitor of apoptosis (XIAP) prevents islet allograft rejection. We constructed an adeno-associated virus expressing XIAP driven by the rat insulin promoter (dsAAV8-RIP-XIAP) for long-term beta-cell gene expression in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25526c183a54ded8d43d786390012562
https://doi.org/10.1016/j.mce.2018.05.015
https://doi.org/10.1016/j.mce.2018.05.015
Autor:
Galina Soukhatcheva, Derek L. Dai, Dan S. Luciani, Mei Tang, Benny Tang, C. Bruce Verchere, Yuanjie Zou
Publikováno v:
Canadian Journal of Diabetes. 44:S6-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1411d62c6460de43264df82a07437ae1
https://doi.org/10.1016/j.jcjd.2020.08.019
https://doi.org/10.1016/j.jcjd.2020.08.019
Autor:
Jaques A. Courtade, Evan Y. Wang, Derek L. Dai, Paul C. Orban, C. Bruce Verchere, Paul M. Yen, Galina Soukhatcheva
Publikováno v:
Diabetologia. 60:453-463
A contributor to beta cell failure in type 2 diabetes and islet transplants is amyloid formation by aggregation of the beta cell peptide, islet amyloid polypeptide (IAPP). Similar to the proinsulin processing pathway that generates insulin, IAPP is d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c99d8a847407f1d3407b1303b521bd
https://doi.org/10.1007/s00125-016-4174-2
https://doi.org/10.1007/s00125-016-4174-2
Autor:
C. Bruce Verchere, Sigrid Alvarez, Galina Soukhatcheva, Derek L. Dai, Paul C. Orban, Loraine Bischoff
Publikováno v:
The Journal of Immunology. 194:3054-3064
Autoimmune destruction of insulin-producing β cells in type 1 diabetes and islet transplantation involves a variety of immune pathways but is primarily mediated by self-reactive T cells. Chemokines can modulate local immune responses in inflammation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9569893e191121764eb989788950314
https://doi.org/10.4049/jimmunol.1400567
https://doi.org/10.4049/jimmunol.1400567
Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets
Autor:
Megan K. Levings, Galina Soukhatcheva, C. Bruce Verchere, Timothy J. Kieffer, Derek L. Dai, Gijs Hardenberg, Paul C. Orban, Joel Montane, Rusung Tan, Loraine Bischoff
Publikováno v:
Journal of Clinical Investigation. 121:3024-3028
Type 1 diabetes is characterized by destruction of insulin-producing β cells in the pancreatic islets by effector T cells. Tregs, defined by the markers CD4 and FoxP3, regulate immune responses by suppressing effector T cells and are recruited to si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654aff26fab56fa9f70cb0274078ddd1
https://doi.org/10.1172/jci43048
https://doi.org/10.1172/jci43048