Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Derek L Bolhuis"'
1
Akademický článek
Crystal structure of the Arabidopsis SPIRAL2 C-terminal domain reveals a p80-Katanin-like domain.
Autor: Derek L Bolhuis, Ram Dixit, Kevin C Slep
Publikováno v: PLoS ONE, Vol 18, Iss 12, p e0290024 (2023)
Epidermal cells of dark-grown plant seedlings reorient their cortical microtubule arrays in response to blue light from a net lateral orientation to a net longitudinal orientation with respect to the long axis of cells. The molecular mechanism underl
Externí odkaz: https://doaj.org/article/c330a335dc48431eb8f42ba842c327aa
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2
Akademický článek
In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.
Autor: Jennifer L Franks, Raquel C Martinez-Chacin, Xianxi Wang, Rochelle L Tiedemann, Thomas Bonacci, Rajarshi Choudhury, Derek L Bolhuis, Taylor P Enrico, Ryan D Mouery, Jeffrey S Damrauer, Feng Yan, Joseph S Harrison, M Ben Major, Katherine A Hoadley, Aussie Suzuki, Scott B Rothbart, Nicholas G Brown, Michael J Emanuele
Publikováno v: PLoS Biology, Vol 18, Iss 12, p e3000975 (2020)
The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase and critical regulator of cell cycle progression. Despite its vital role, it has remained challenging to globally map APC/C substrates. By combining orthogonal features of kno
Externí odkaz: https://doaj.org/article/5996078700384ca5bbd42dde1d166f90
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3
Akademický článek
Cryo-EM structure of the plant 26S proteasome
Autor: Susanne Kandolf, Irina Grishkovskaya, Katarina Belačić, Derek L. Bolhuis, Sascha Amann, Brent Foster, Richard Imre, Karl Mechtler, Alexander Schleiffer, Hemant D. Tagare, Ellen D. Zhong, Anton Meinhart, Nicholas G. Brown, David Haselbach
Publikováno v: Plant Communications, Vol 3, Iss 3, Pp 100310- (2022)
Targeted proteolysis is a hallmark of life. It is especially important in long-lived cells that can be found in higher eukaryotes, like plants. This task is mainly fulfilled by the ubiquitin–proteasome system. Thus, proteolysis by the 26S proteasom
Externí odkaz: https://doaj.org/article/e84407552dfe4c3fa9b1dd07a5258c88
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5
AtomNet-Aided OTUD7B Inhibitor Discovery and Validation
Autor: Jianfeng Chen, Derek L. Bolhuis, Christian Laggner, Deyu Kong, Le Yu, Xiaodong Wang, Michael J. Emanuele, Nicholas G. Brown, Pengda Liu
Publikováno v: Cancers; Volume 15; Issue 2; Pages: 517
Protein deubiquitinases play critical pathophysiological roles in cancer. Among all deubiquitinases, an oncogenic function for OTUD7B has been established in genetic NSCLC murine models. However, few deubiquitinase inhibitors have been developed due
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33a00fe34824d81a464898bd366ce3c
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6
Crystal structure of theArabidopsisSPIRAL2 C-terminal domain reveals a p80-Katanin-like domain
Autor: Derek L. Bolhuis, Ram Dixit, Kevin C. Slep
Epidermal cells of dark-grown plant seedlings reorient their cortical microtubule arrays in response to blue light from a net lateral orientation to a net longitudinal orientation with respect to the long axis of cells. The molecular mechanism underl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::614e23ad3043525188c10e15f38310e4
https://doi.org/10.1101/2022.12.28.522140
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8
Cryo-EM structure of the chain-elongating E3 ligase UBR5
Autor: Zuzana Hodáková, Irina Grishkovskaya, Hanna L. Brunner, Derek L. Bolhuis, Katarina Belačić, Alexander Schleiffer, Harald Kotisch, Nicholas G. Brown, David Haselbach
UBR5 is a nuclear E3 ligase that ubiquitinates a vast range of substrates for proteasomal degradation. This HECT E3 ligase has recently been identified as an important regulator of oncogenes, e.g., MYC, but little is known about its structure or mech
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a8850cf82fe952b3f3cd2b945d3fbf3
https://doi.org/10.1101/2022.11.03.515015
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10
Examining the mechanistic relationship of APC/C
Autor: Derek L, Bolhuis, Raquel C, Martinez-Chacin, Kaeli A, Welsh, Tatyana, Bodrug, Liying, Cui, Michael J, Emanuele, Nicholas G, Brown
Publikováno v: Protein Sci
Proper protein destruction by the ubiquitin (Ub)‐proteasome system is vital for a faithful cell cycle. Hence, the activity of Ub ligases is tightly controlled. The Anaphase‐Promoting Complex/Cyclosome (APC/C) is a 1.2 MDa Ub ligase responsible fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::16c95a26fa47704bf377fcdcf15fe845
https://pubmed.ncbi.nlm.nih.gov/35634770
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