Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Derek J. Eberwein"'
Autor:
Rakesh Kumar, Robert A. Copeland, Pearl S. Huang, Edgar R. Wood, Susan L. Strum, Elisabeth A. Minthorn, Jack D. Leber, Zhihong Lai, Anthony E. Choudhry, Elena V. Kleymenova, Robert S. Geske, Jason A. Kahana, Kimberly Robell, Shu-Yun Zhang, Tona M. Gilmer, Randy T. McConnell, Timothy J. Lansing, Victoria B. Knick, Derek J. Eberwein, Derek R. Duckett, Dirk A. Heerding, Nelson Rhodes
Supplementary Methods and Figure Legends 1-2 from Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a3405f44d49aec54206ba52ba0d265
https://doi.org/10.1158/0008-5472.22370963
https://doi.org/10.1158/0008-5472.22370963
Autor:
Rakesh Kumar, Robert A. Copeland, Pearl S. Huang, Edgar R. Wood, Susan L. Strum, Elisabeth A. Minthorn, Jack D. Leber, Zhihong Lai, Anthony E. Choudhry, Elena V. Kleymenova, Robert S. Geske, Jason A. Kahana, Kimberly Robell, Shu-Yun Zhang, Tona M. Gilmer, Randy T. McConnell, Timothy J. Lansing, Victoria B. Knick, Derek J. Eberwein, Derek R. Duckett, Dirk A. Heerding, Nelson Rhodes
Supplementary Figure 2 from Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426e3e38118b83488267a117b29c53cd
https://doi.org/10.1158/0008-5472.22370966
https://doi.org/10.1158/0008-5472.22370966
Autor:
Rakesh Kumar, Robert A. Copeland, Pearl S. Huang, Edgar R. Wood, Susan L. Strum, Elisabeth A. Minthorn, Jack D. Leber, Zhihong Lai, Anthony E. Choudhry, Elena V. Kleymenova, Robert S. Geske, Jason A. Kahana, Kimberly Robell, Shu-Yun Zhang, Tona M. Gilmer, Randy T. McConnell, Timothy J. Lansing, Victoria B. Knick, Derek J. Eberwein, Derek R. Duckett, Dirk A. Heerding, Nelson Rhodes
Supplementary Figure 1 from Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4abec9d184e4e3594165c4dd227e1f2
https://doi.org/10.1158/0008-5472.22370972.v1
https://doi.org/10.1158/0008-5472.22370972.v1
Autor:
Laurel M. Adams, Lyndon C. Kirby, Robert A. Blum, Christian D. Lates, Derek J. Eberwein, Sharon C. Murray, Ke Zhang, Shannon R. Morris, Brendan M. Johnson
Publikováno v:
The Journal of Clinical Pharmacology. 50:566-575
Casopitant, a novel NK-1 receptor antagonist under investigation for the prevention of postoperative and chemotherapy-induced nausea and vomiting, is a weak to moderate inhibitor of CYP3A and a moderate inducer of CYP2C9 in vitro. Furthermore, both C
Autor:
Jason Kahana, Susan Korenchuk, Shu-Yun Zhang, Kathleen K. Brown, Ming-Chih Crouthamel, Rakesh Kumar, Derek J. Eberwein, Gobalakrishnan Sundaresan
Publikováno v:
Clinical Cancer Research. 15:217-225
Purpose: Insulin-like growth factor-I receptor and phosphoinositide 3-kinase/AKT/mammalian target of rapamycin pathways are among the most active areas of drug discovery in cancer research. However, due to their integral roles in insulin signaling, i
Publikováno v:
JNCI Journal of the National Cancer Institute. 87:1072-1077
Background : Many critical cellular functions such as mitosis, cell movement, and maintenance of cell structure are performed by microtubules. Antimicrotubule agents (which disrupt or block the formation of microtubules) are among the most widely use
Autor:
Anthony E. Choudhry, Igor G. Safonov, Dirk A. Heerding, Jack D. Leber, Nelson Rhodes, Susan L. Strum, Mei Li, Michael D. Schaber, Peter J. Tummino, Derek J. Eberwein, Victoria B. Knick, Louis V. LaFrance, Robert A. Copeland, Timothy J. Lansing, Derek R. Duckett, Edgar R. Wood, Richard M. Keenan, Gregory L. Warren, Zhihong Lai, Joseph W. Venslavsky, Randy T. McConnell, Dennis S. Yamashita, Dennis T. Takata, Nestor O. Concha, Rakesh Kumar, Elisabeth A. Minthorn, Tammy J. Clark, Shu-Yun Zhang
Publikováno v:
Journal of medicinal chemistry. 51(18)
Overexpression of AKT has an antiapoptotic effect in many cell types, and expression of dominant negative AKT blocks the ability of a variety of growth factors to promote survival. Therefore, inhibitors of AKT kinase activity might be useful as monot
Autor:
Derek J. Eberwein, Christian H. Ryan, Sam M. Witherspoon, Julie B. Stimmel, Linda M. Thurmond, Adrienne C. Ingram, Doris M. Murray, Vincent C. Knick
Publikováno v:
Cancer immunology, immunotherapy : CII. 52(7)
Ep-CAM antigen expression was shown to vary by phase across the cell cycle. Following pretreatment of various adenocarcinoma cells in culture with clinically relevant concentrations of vinorelbine tartrate (Navelbine) or paclitaxel (Taxol), cell surf
Autor:
William D. Holmes, Lee F. Kuyper, Robert T. Gampe, James Marvin Veal, Robert N. Hunter, Lisa M. Shewchuk, Stephen T. Davis, Karen Lackey, Bill G. Benson, Karen M. Dold, Doris M. Murray, Anne M. Hassell, Derek J. Eberwein, Victoria B. Knick, Patricia G. Parker, Stephen V. Frye, Duncan Herrick Walker, Robert J. Griffin, Scott Howard Dickerson, Dennis E. Chapman, Michael Joseph Luzzio, Philip A. Harris, Mark Edelstein, Brett Lovejoy, H. Neal Bramson, Warren J. Rocque
Publikováno v:
Science (New York, N.Y.). 291(5501)
Most traditional cytotoxic anticancer agents ablate the rapidly dividing epithelium of the hair follicle and induce alopecia (hair loss). Inhibition of cyclin-dependent kinase 2 (CDK2), a positive regulator of eukaryotic cell cycle progression, may r
Publisher Summary One of the gene families most commonly found mutated in human tumors is the ras gene family. Ras has been shown to regulate several pathways that contribute to cellular transformation, including the Rac and Rho pathways and the Raf-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cc45b66923b1db93bc085341dce29dd
https://doi.org/10.1016/s0076-6879(01)32215-2
https://doi.org/10.1016/s0076-6879(01)32215-2