Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Derek J Pickard"'
Autor:
Fatemeh A. Ghomi, Jakob J. Jung, Gemma C. Langridge, Amy K. Cain, Christine J. Boinett, Moataz Abd El Ghany, Derek J. Pickard, Robert A. Kingsley, Nicholas R. Thomson, Julian Parkhill, Paul P. Gardner, Lars Barquist
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT The Enterobacteriaceae are a scientifically and medically important clade of bacteria, containing the model organism Escherichia coli, as well as major human pathogens including Salmonella enterica and Klebsiella pneumoniae. Essential gene s
Externí odkaz:
https://doaj.org/article/a87d09f8046541e6bfde3132902797c0
Autor:
International Typhoid Consortium, Vanessa K Wong, Kathryn E Holt, Chinyere Okoro, Stephen Baker, Derek J Pickard, Florian Marks, Andrew J Page, Grace Olanipekun, Huda Munir, Roxanne Alter, Paul D Fey, Nicholas A Feasey, Francois-Xavier Weill, Simon Le Hello, Peter J Hart, Samuel Kariuki, Robert F Breiman, Melita A Gordon, Robert S Heyderman, Jan Jacobs, Octavie Lunguya, Chisomo Msefula, Calman A MacLennan, Karen H Keddy, Anthony M Smith, Robert S Onsare, Elizabeth De Pinna, Satheesh Nair, Ben Amos, Gordon Dougan, Stephen Obaro
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 9, p e0004781 (2016)
BACKGROUND:The burden of typhoid in sub-Saharan African (SSA) countries has been difficult to estimate, in part, due to suboptimal laboratory diagnostics. However, surveillance blood cultures at two sites in Nigeria have identified typhoid associated
Externí odkaz:
https://doaj.org/article/fa793f36c1794c909866b8b2695c2627
Autor:
Katharina eSchaufler, Torsten eSemmler, Derek J Pickard, Maria ede Toro, Fernando ede la Cruz, Lothar H Wieler, Christa eEwers, Sebastian eGuenther
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
Pathogenic ESBL-producing E. coli lineages occur frequently worldwide, not only in a human health context but in animals and the environment, also in settings with low antimicrobial pressures. This study investigated the fitness costs of ESBL-plasmid
Externí odkaz:
https://doaj.org/article/06eb6514d92b45febd68d6335212ed3f
Autor:
Chinyere K Okoro, Lars Barquist, Thomas R Connor, Simon R Harris, Simon Clare, Mark P Stevens, Mark J Arends, Christine Hale, Leanne Kane, Derek J Pickard, Jennifer Hill, Katherine Harcourt, Julian Parkhill, Gordon Dougan, Robert A Kingsley
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 6, p e0003848 (2015)
Externí odkaz:
https://doaj.org/article/0b5d6a3199694652bf48803c989cc941
Autor:
Chinyere K Okoro, Lars Barquist, Thomas R Connor, Simon R Harris, Simon Clare, Mark P Stevens, Mark J Arends, Christine Hale, Leanne Kane, Derek J Pickard, Jennifer Hill, Katherine Harcourt, Julian Parkhill, Gordon Dougan, Robert A Kingsley
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 3, p e0003611 (2015)
Two lineages of Salmonella enterica serovar Typhimurium (S. Typhimurium) of multi-locus sequence type ST313 have been linked with the emergence of invasive Salmonella disease across sub-Saharan Africa. The expansion of these lineages has a temporal a
Externí odkaz:
https://doaj.org/article/19d3bc0a149848cbba6fc1b1f3944b49
Autor:
Vanessa K Wong, Derek J Pickard, Lars Barquist, Karthikeyan Sivaraman, Andrew J Page, Peter J Hart, Mark J Arends, Kathryn E Holt, Leanne Kane, Lynda F Mottram, Louise Ellison, Ruben Bautista, Chris J McGee, Sally J Kay, Thomas M Wileman, Linda J Kenney, Calman A MacLennan, Robert A Kingsley, Gordon Dougan
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84567 (2013)
Proteins exhibiting hyper-variable sequences within a bacterial pathogen may be associated with host adaptation. Several lineages of the monophyletic pathogen Salmonella enterica serovar Typhi (S. Typhi) have accumulated non-synonymous mutations in t
Externí odkaz:
https://doaj.org/article/bb1ce64e4c7d46c89803e02b3595fa20
Autor:
Trevor D Lawley, Simon Clare, Alan W Walker, Mark D Stares, Thomas R Connor, Claire Raisen, David Goulding, Roland Rad, Fernanda Schreiber, Cordelia Brandt, Laura J Deakin, Derek J Pickard, Sylvia H Duncan, Harry J Flint, Taane G Clark, Julian Parkhill, Gordon Dougan
Publikováno v:
PLoS Pathogens, Vol 8, Iss 10, p e1002995 (2012)
Relapsing C. difficile disease in humans is linked to a pathological imbalance within the intestinal microbiota, termed dysbiosis, which remains poorly understood. We show that mice infected with epidemic C. difficile (genotype 027/BI) develop highly
Externí odkaz:
https://doaj.org/article/e29efcffca5d4832924a324b0e3c1a00
Autor:
Kathryn E Holt, Shanta Dutta, Byomkesh Manna, Sujit K Bhattacharya, Barnali Bhaduri, Derek J Pickard, R Leon Ochiai, Mohammad Ali, John D Clemens, Gordon Dougan
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 1, p e1490 (2012)
Typhoid fever, caused by Salmonella enterica serovar Typhi (S. Typhi), is a major health problem especially in developing countries. Vaccines against typhoid are commonly used by travelers but less so by residents of endemic areas.We used single nucl
Externí odkaz:
https://doaj.org/article/affce46230a64b67a8c7d95ffbf6554e
Autor:
Timothy T Perkins, Robert A Kingsley, Maria C Fookes, Paul P Gardner, Keith D James, Lu Yu, Samuel A Assefa, Miao He, Nicholas J Croucher, Derek J Pickard, Duncan J Maskell, Julian Parkhill, Jyoti Choudhary, Nicholas R Thomson, Gordon Dougan
Publikováno v:
PLoS Genetics, Vol 5, Iss 7, p e1000569 (2009)
High-density, strand-specific cDNA sequencing (ssRNA-seq) was used to analyze the transcriptome of Salmonella enterica serovar Typhi (S. Typhi). By mapping sequence data to the entire S. Typhi genome, we analyzed the transcriptome in a strand-specifi
Externí odkaz:
https://doaj.org/article/265dd21c5b284d13a9e26e218b864638
Autor:
Rhys A. Dunstan, Rebecca S. Bamert, Kher Shing Tan, Uvini Imbulgoda, Christopher K. Barlow, George Taiaroa, Derek J. Pickard, Ralf B. Schittenhelm, Gordon Dougan, Francesca L. Short, Trevor Lithgow
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112551- (2023)
Summary: To kill bacteria, bacteriophages (phages) must first bind to a receptor, triggering the release of the phage DNA into the bacterial cell. Many bacteria secrete polysaccharides that had been thought to shield bacterial cells from phage attack
Externí odkaz:
https://doaj.org/article/d36ebda4f714404e840fef3dffb1b1a2