Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Derek Gao"'
Autor:
Blue B. Lake, Song Chen, Masato Hoshi, Nongluk Plongthongkum, Diane Salamon, Amanda Knoten, Anitha Vijayan, Ramakrishna Venkatesh, Eric H. Kim, Derek Gao, Joseph Gaut, Kun Zhang, Sanjay Jain
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Single-cell studies in solid tissues remain challenging and have benefited from the development of single-nuclei RNA sequencing strategies. Here Lake et al. apply single-nucleus RNA sequencing to human kidney tissues to provide a comprehensive molecu
Externí odkaz:
https://doaj.org/article/1626047e2e3b4f4c8010bc3a23111c9a
Autor:
Blue B. Lake, Simone Codeluppi, Yun C. Yung, Derek Gao, Jerold Chun, Peter V. Kharchenko, Sten Linnarsson, Kun Zhang
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Significant heterogeneities in gene expression among individual cells are typically interrogated using single whole cell approaches. However, tissues that have highly interconnected processes, such as in the brain, present unique challenges.
Externí odkaz:
https://doaj.org/article/decb1c554c2c448c9346ed00418f1885
Autor:
Diane Salamon, Eric H. Kim, Derek Gao, Nongluk Plongthongkum, Joseph P. Gaut, Ramakrishna Venkatesh, Amanda Knoten, Anitha Vijayan, Song Chen, Sanjay Jain, Blue B. Lake, Masato Hoshi, Kun Zhang
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature communications, vol 10, iss 1
Defining cellular and molecular identities within the kidney is necessary to understand its organization and function in health and disease. Here we demonstrate a reproducible method with minimal artifacts for single-nucleus Droplet-based RNA sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1033e20243b24df2c2adc37e73aaeaea
http://europepmc.org/articles/PMC6597610
http://europepmc.org/articles/PMC6597610
Autor:
Blue B. Lake, Song Chen, Brandon C. Sos, Jean Fan, Yun Yung, Gwendolyn E. Kaeser, Thu E. Duong, Derek Gao, Jerold Chun, Peter Kharchenko, Kun Zhang
Detailed characterization of the cell types comprising the highly complex human brain is essential to understanding its function. Such tasks require highly scalable experimental approaches to examine different aspects of the molecular state of indivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a84d24561e7ed59b01ad4be6867016a
https://doi.org/10.1101/128520
https://doi.org/10.1101/128520
Autor:
Gwendolyn E. Kaeser, Jean Fan, Brandon C. Sos, Kun Zhang, Derek Gao, Thu Elizabeth Duong, Yun C. Yung, Peter V. Kharchenko, Jerold Chun, Blue B. Lake, Song Chen
Publikováno v:
Nature biotechnology, vol 36, iss 1
Nature biotechnology
Nature biotechnology
Detailed characterization of the cell types in the human brain requires scalable experimental approaches to examine multiple aspects of the molecular state of individual cells, as well as computational integration of the data to produce unified cell-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e141bb798d2fedfac7e2c8fbf529bbd
https://pubmed.ncbi.nlm.nih.gov/29319686
https://pubmed.ncbi.nlm.nih.gov/29319686
Autor:
Ho-Lim Fung, Xiaoyan Sheng, Kun Zhang, Richard Shen, Julian Wong, Jerold Chun, Andre Wildberg, Wei Wang, Fiona Kaper, Derek Gao, Rizi Ai, Jian-Bing Fan, Rui Liu, Blue B. Lake, Neeraj Salathia, Yun C. Yung, Mostafa Ronaghi, Allison Chen, Gwendolyn E. Kaeser, Raakhee Vijayaraghavan, Song Chen
Publikováno v:
Science (New York, N.Y.), vol 352, iss 6293
Lake, BB; Ai, R; Kaeser, GE; Salathia, NS; Yung, YC; Liu, R; et al.(2016). Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain. SCIENCE, 352(6293), 1586-1590. doi: 10.1126/science.aaf1204. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/7tp2q0jr
Lake, BB; Ai, R; Kaeser, GE; Salathia, NS; Yung, YC; Liu, R; et al.(2016). Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain. SCIENCE, 352(6293), 1586-1590. doi: 10.1126/science.aaf1204. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/7tp2q0jr
Single-nucleus gene expression Identifying the genes expressed at the level of a single cell nucleus can better help us understand the human brain. Blue et al. developed a single-nuclei sequencing technique, which they applied to cells in classically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c45b3bea607e2f560162accb37c970
https://escholarship.org/uc/item/7tp2q0jr
https://escholarship.org/uc/item/7tp2q0jr
Autor:
Ho-Lim Fung, Derek Gao, Amirali Kia, Brandon C. Sos, Kun Zhang, Trina Faye Osothprarop, Molly He
Publikováno v:
Genome biology, vol 17, iss 1
Genome Biology
Genome Biology
Chromatin accessibility captures in vivo protein-chromosome binding status, and is considered an informative proxy for protein-DNA interactions. DNase I and Tn5 transposase assays require thousands to millions of fresh cells for comprehensive chromat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45457049ecd4b3ee9f12b9ac750c2cdd
https://escholarship.org/uc/item/0g9401xq
https://escholarship.org/uc/item/0g9401xq
Publikováno v:
Powder Technology. 213:155-161
In this paper, an algorithm based on boundary-line analysis is developed for the first time to directly recognize polygon shapes with or without concaved angles and without any pre-stored shape templates. The algorithm is also capable of quantitative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c86c8a733163ff7529587847f8464d5
https://doi.org/10.1016/j.powtec.2011.07.028
https://doi.org/10.1016/j.powtec.2011.07.028