Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Derek G Sim"'
Autor:
Valerie J Morley, Clare L Kinnear, Derek G Sim, Samantha N Olson, Lindsey M Jackson, Elsa Hansen, Grace A Usher, Scott A Showalter, Manjunath P Pai, Robert J Woods, Andrew F Read
Publikováno v:
eLife, Vol 9 (2020)
A key challenge in antibiotic stewardship is figuring out how to use antibiotics therapeutically without promoting the evolution of antibiotic resistance. Here, we demonstrate proof of concept for an adjunctive therapy that allows intravenous antibio
Externí odkaz:
https://doaj.org/article/a1a0ef55660049aaa1bfa3ba8c496de1
Autor:
Peter J Kerr, Isabella M Cattadori, Matthew B Rogers, Adam Fitch, Adam Geber, June Liu, Derek G Sim, Brian Boag, John-Sebastian Eden, Elodie Ghedin, Andrew F Read, Edward C Holmes
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006252 (2017)
The co-evolution of myxoma virus (MYXV) and the European rabbit occurred independently in Australia and Europe from different progenitor viruses. Although this is the canonical study of the evolution of virulence, whether the genomic and phenotypic o
Externí odkaz:
https://doaj.org/article/1cdd3a406cd84d6297b7a0bf69cf6574
Autor:
Laura C Pollitt, Silvie Huijben, Derek G Sim, Rahel M Salathé, Matthew J Jones, Andrew F Read
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004019 (2014)
The evolution of drug resistance, a key challenge for our ability to treat and control infections, depends on two processes: de-novo resistance mutations, and the selection for and spread of resistant mutants within a population. Understanding the fa
Externí odkaz:
https://doaj.org/article/67bf92882bc64db4bb489730da5801c1
Autor:
Silvie Huijben, Andrew S Bell, Derek G Sim, Danielle Tomasello, Nicole Mideo, Troy Day, Andrew F Read
Publikováno v:
PLoS Pathogens, Vol 9, Iss 9, p e1003578 (2013)
Drug resistant pathogens are one of the key public health challenges of the 21st century. There is a widespread belief that resistance is best managed by using drugs to rapidly eliminate target pathogens from patients so as to minimize the probabilit
Externí odkaz:
https://doaj.org/article/0adf4f17574f44b1b92dc7eb29d68381
Autor:
Andrew S Bell, Silvie Huijben, Krijn P Paaijmans, Derek G Sim, Brian H K Chan, William A Nelson, Andrew F Read
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e37172 (2012)
The evolution of drug resistant Plasmodium parasites is a major challenge to effective malaria control. In theory, competitive interactions between sensitive parasites and resistant parasites within infections are a major determinant of the rate at w
Externí odkaz:
https://doaj.org/article/108fb64e4c4b4ccd980aadd54475c8b3
Autor:
Devanshi R. Patel, Allen M. Minns, Derek G. Sim, Cassandra J. Field, Abigail E. Kerr, Talia A. Heinly, Erin H. Luley, Randall M. Rossi, Carol M. Bator, Ibrahim M. Moustafa, Elizabeth B. Norton, Susan L. Hafenstein, Scott E. Lindner, Troy C. Sutton
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 3 (2024)
ABSTRACTMultiple vaccines have been developed and licensed for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). While these vaccines reduce disease severity, they do not prevent infection. To prevent infection and limit transmission, vac
Externí odkaz:
https://doaj.org/article/55f1a1bf25284935bbdcb7a25dab70bd
Publikováno v:
Evolution, Medicine, and Public Health. 10:439-446
Background and objectives Previously, we showed proof-of-concept in a mouse model that oral administration of cholestyramine prevented enrichment of daptomycin-resistant Enterococcus faecium in the gastrointestinal (GI) tract during daptomycin therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe73f2d799486055ec54463fea926a9
https://doi.org/10.1093/emph/eoac035
https://doi.org/10.1093/emph/eoac035
Background and ObjectivesPreviously, we showed proof-of-concept in a mouse model that oral administration of cholestyramine prevented enrichment of daptomycin-resistant Enterococcus faecium in the gastrointestinal (GI) tract during daptomycin therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a39b4e6b7925bce179704c483b4dfb99
https://doi.org/10.1101/2022.05.25.493495
https://doi.org/10.1101/2022.05.25.493495
Publikováno v:
Evolution, Medicine, and Public Health. 2020:196-210
Background and objectives There is a significant interest in identifying clinically effective drug treatment regimens that minimize the de novo evolution of antimicrobial resistance in pathogen populations. However, in vivo studies that vary treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c532e38db67eb5206098af7ee683ff66
https://doi.org/10.1093/emph/eoaa016
https://doi.org/10.1093/emph/eoaa016
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance What makes an infected host sick—the pathogen or the host response to it? How should pathogens defend themselves? Answering these questions requires an understanding of how, and how much, the immune response changes populations of host
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3caf83d92b0754731fd5ea0a2270b615
https://doi.org/10.1073/pnas.1908147116
https://doi.org/10.1073/pnas.1908147116