Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Derek Drake"'
Autor:
Liviu Aron, Chenxi Qiu, Zhen Kai Ngian, Marianna Liang, Derek Drake, Jaejoon Choi, Marty A. Fernandez, Perle Roche, Emma L. Bunting, Ella K. Lacey, Sara E. Hamplova, Monlan Yuan, Michael S. Wolfe, David A. Bennett, Eunjung A. Lee, Bruce A. Yankner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Many aging individuals accumulate the pathology of Alzheimer’s disease (AD) without evidence of cognitive decline. Here we describe an integrated neurodegeneration checkpoint response to early pathological changes that restricts further di
Externí odkaz:
https://doaj.org/article/e84a41f3caaa44a194226f2627e04640
Autor:
Katharina Meyer, Heather M. Feldman, Tao Lu, Derek Drake, Elaine T. Lim, King-Hwa Ling, Nicholas A. Bishop, Ying Pan, Jinsoo Seo, Yuan-Ta Lin, Susan C. Su, George M. Church, Li-Huei Tsai, Bruce A. Yankner
Publikováno v:
Cell Reports, Vol 26, Iss 5, Pp 1112-1127.e9 (2019)
Summary: The molecular basis of the earliest neuronal changes that lead to Alzheimer’s disease (AD) is unclear. Here, we analyze neural cells derived from sporadic AD (SAD), APOE4 gene-edited and control induced pluripotent stem cells (iPSCs). We o
Externí odkaz:
https://doaj.org/article/badcc8e4bd05429e89f06087a8cb13bb
Autor:
Derek Drake, Alexander Kramer
Publikováno v:
Yearbook of German-American Studies. 49:167-194
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5e27f4d9ad067539d270bad14d508f6
https://doi.org/10.17161/ygas.v49i.18166
https://doi.org/10.17161/ygas.v49i.18166
Autor:
Yiyuan Xia, Hiroshi Qadota, Zhi-Hao Wang, Pai Liu, Xia Liu, Karen X. Ye, Courtney J. Matheny, Ken Berglund, Shan Ping Yu, Derek Drake, David A. Bennett, Xiao-Chuan Wang, Bruce A. Yankner, Guy M. Benian, Keqiang Ye
Publikováno v:
Science Advances. 8
The age-related cognitive decline of normal aging is exacerbated in neurodegenerative diseases including Alzheimer’s disease (AD). However, it remains unclear whether age-related cognitive regulators in AD pathologies contribute to life span. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965a636fee52c847830b4fd4c6b16665
https://doi.org/10.1126/sciadv.abj8658
https://doi.org/10.1126/sciadv.abj8658
Autor:
Derek Drake
Publikováno v:
The Palgrave Encyclopedia of Critical Perspectives on Mental Health ISBN: 9783030128524
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afc079da7780ee6c96c6c9d2670321d3
https://doi.org/10.1007/978-3-030-12852-4_10-1
https://doi.org/10.1007/978-3-030-12852-4_10-1
Autor:
Monica P. Colaiácovo, Bruce A. Yankner, Joseph M. Zullo, David A. Bennett, William H. Klein, Derek Drake, Patrick O’Hern, Noah Davidsohn, Sameer C. Dhamne, Liviu Aron, Chai An Mao, George M. Church, Alexander Rotenberg
Publikováno v:
Nature
The mechanisms that extend lifespan in humans are poorly understood. Here we show that extended longevity in humans is associated with a distinct transcriptome signature in the cerebral cortex that is characterized by downregulation of genes related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1f4c9e899ecb12eaf11ee13d60691c
https://doi.org/10.1038/s41586-019-1647-8
https://doi.org/10.1038/s41586-019-1647-8
Autor:
Derek Drake, Veronika Drake
Publikováno v:
Die Unterrichtspraxis/Teaching German. 48:146-161
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a536364c44c8a87519ddc5eae94d3516
https://doi.org/10.1111/tger.10186
https://doi.org/10.1111/tger.10186
Autor:
Haeyoung Kim, Ying Pan, Tun Hsiang Yang, Hyun-Min Kim, Tao Lu, Liviu Aron, Monica P. Colaiácovo, Yiwen Chen, David A. Bennett, Joseph M. Zullo, Derek Drake, Bruce A. Yankner, X. Shirley Liu
Publikováno v:
Nature
Human neurons are functional over an entire lifetime, yet the mechanisms that preserve function and protect against neurodegeneration during ageing are unknown. Here we show that induction of the repressor element 1-silencing transcription factor (RE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c73af0ab057ca245cbde688d060b9d4
https://doi.org/10.1038/nature13163
https://doi.org/10.1038/nature13163
Autor:
Li-Huei Tsai, Susan C. Su, Tao Lu, Bruce A. Yankner, Elaine T. Lim, Nicholas A. Bishop, Heather M. Feldman, Katharina Meyer, Yuan Ta Lin, King Hwa Ling, Jinsoo Seo, George M. Church, Ying Pan, Derek Drake
Publikováno v:
Cell reports
Cell Reports, Vol 26, Iss 5, Pp 1112-1127.e9 (2019)
Elsevier
Cell Reports, Vol 26, Iss 5, Pp 1112-1127.e9 (2019)
Elsevier
SUMMARY The molecular basis of the earliest neuronal changes that lead to Alzheimer’s disease (AD) is unclear. Here, we analyze neural cells derived from sporadic AD (SAD), APOE4 gene-edited and control induced pluripotent stem cells (iPSCs). We ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab8514472dffb45e3db2f9d781ca795
https://doi.org/10.1016/j.celrep.2019.01.023
https://doi.org/10.1016/j.celrep.2019.01.023
Autor:
Derek Drake, Tao Lu, Ying Pan, Hyun-Min Kim, Bruce A. Yankner, Haeyoung Kim, Liviu Aron, Monica P. Colaiácovo, Yiwen Chen, Tun-Hsiang Yang, David A. Bennett, Joseph M. Zullo, X. Shirley Liu
Publikováno v:
eNeuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a19bb62e16d4e9e67df2762478432ae
https://doi.org/10.1038/nature20579
https://doi.org/10.1038/nature20579