Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Derek Dang"'
Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD
Autor:
Mark L. Schultz, Kelsey L. Krus, Susmita Kaushik, Derek Dang, Ravi Chopra, Ling Qi, Vikram G. Shakkottai, Ana Maria Cuervo, Andrew P. Lieberman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Niemann-Pick type C1 disease is most commonly caused by the allele NPC1 I1061T, which is misfolded in the ER and rapidly degraded by the ubiquitin proteasome system. Here the authors show that the I1061T mutant is also degraded by ER-phagy.
Externí odkaz:
https://doaj.org/article/fa59083b03654256906367e10286935a
Autor:
Parthiv Haldipur, Derek Dang, Kimberly A Aldinger, Olivia K Janson, Fabien Guimiot, Homa Adle-Biasette, William B Dobyns, Joseph R Siebert, Rosa Russo, Kathleen J Millen
Publikováno v:
eLife, Vol 6 (2017)
FOXC1 loss contributes to Dandy-Walker malformation (DWM), a common human cerebellar malformation. Previously, we found that complete Foxc1 loss leads to aberrations in proliferation, neuronal differentiation and migration in the embryonic mouse cere
Externí odkaz:
https://doaj.org/article/08a5168aebb147bb89ad289933a1214c
Autor:
Dipika R. Mohan, Kleiton S. Borges, Isabella Finco, Christopher R. LaPensee, Juilee Rege, April L. Solon, Donald W. Little, Tobias Else, Madson Q. Almeida, Derek Dang, James Haggerty-Skeans, April A. Apfelbaum, Michelle Vinco, Alda Wakamatsu, Beatriz M. P. Mariani, Larissa Costa. Amorim, Ana Claudia. Latronico, Berenice B. Mendonca, Maria Claudia N. Zerbini, Elizabeth R. Lawlor, Ryoma Ohi, Richard J. Auchus, William E. Rainey, Suely K.N. Marie, Thomas J. Giordano, Sriram Venneti, Maria Candida Barisson Villares Fragoso, David T. Breault, Antonio Marcondes. Lerario, Gary D. Hammer
Publikováno v:
Cancer Research.
Adrenocortical carcinoma (ACC) is a rare cancer in which tissue-specific differentiation is paradoxically associated with dismal outcomes. The differentiated ACC subtype CIMP-high is prevalent, incurable, and routinely fatal. CIMP-high ACC possess ab
Autor:
Andrew E. Timms, Danilo Dubocanin, Cira Di Gioia, Rosa Russo, Derek Dang, Kathleen J. Millen, Ozgur Oztekin, Lucia Manganaro, Alexandria H Sjoboen, Brian D Davis, Kimberly A. Aldinger, Fabien Guimiot, Ian A. Glass, Jake Millman, Evelina Silvestri, Homa Adle-Biassette, Mei Deng, Tarika Sivakumar, Parthiv Haldipur, Ferechté Razavi, Kshitij Mankad, Nathalie Roux, Joseph R. Siebert, Silvia Bernardo, Giulia Petrilli, Debora Kidron, Jasmine T. Plummer
Publikováno v:
Acta Neuropathol
Dandy-Walker malformation (DWM) and Cerebellar vermis hypoplasia (CVH) are commonly recognized human cerebellar malformations diagnosed following ultrasound and antenatal or postnatal MRI. Specific radiological criteria are used to distinguish them,
β-catenin programs a tissue-specific epigenetic vulnerability in aggressive adrenocortical carcinoma
Autor:
Dipika R. Mohan, Kleiton S. Borges, Isabella Finco, Christopher R. LaPensee, Juilee Rege, April L. Solon, Donald W. Little, Tobias Else, Madson Q. Almeida, Derek Dang, James Haggerty-Skeans, April A. Apfelbaum, Michelle Vinco, Alda Wakamatsu, Beatriz MP Mariani, Larissa Amorin, Ana Claudia Latronico, Berenice B. Mendonca, Maria Claudia N. Zerbini, Elizabeth R. Lawlor, Ryoma Ohi, Richard J. Auchus, William E. Rainey, Suely K. N. Marie, Thomas J. Giordano, Sriram Venneti, Maria Candida B. V. Fragoso, David T. Breault, Antonio Marcondes Lerario, Gary D. Hammer
Adrenocortical carcinoma (ACC) is a rare cancer in which tissue-specific differentiation is paradoxically associated with dismal outcomes. The differentiated ACC subtype CIMP-high is prevalent, incurable, and routinely fatal. CIMP-high ACC possess ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9810854af32882553cc7a6cfe3b60b1e
https://doi.org/10.1101/2022.07.02.497654
https://doi.org/10.1101/2022.07.02.497654
Autor:
Dipika R. Mohan, Kleiton S. Borges, Isabella Finco, Christopher R. LaPensee, Juilee Rege, Donald W. Little, Tobias Else, Madson Q. Almeida, Derek Dang, James Haggerty-Skeans, Ana Claudia Latronico, Berenice B. Mendonca, Richard J. Auchus, William E. Rainey, Suely K. Marie, Thomas J. Giordano, Sriram Venneti, Maria Candida B. Fragoso, David T. Breault, Antonio M. Lerario, Gary D. Hammer
Publikováno v:
Cancer Research. 83:1501-1501
Adrenocortical carcinoma (ACC) is a rare cancer of the adrenal cortex without curative medical therapies. CIMP-high is an aggressive ACC molecular subtype defined by global CpG island hypermethylation with paradoxical activation of adrenal differenti
Autor:
Derek Dang, Sahar Moughnyeh, Emily Stephens, Vashti Convers, Sarah Adkins-Jablonsky, Samiksha Raut
Publikováno v:
CourseSource. 9
Autor:
Alexander R. Judkins, Jared Shows, Kyle S. Smith, Pooja Panwalkar, Sriram Venneti, Ashley Margol, Daniel Martinez, Chan Chung, Derek Dang, Jill Bayliss, Mike Adam, Leo Mascarenhas, Paul Le, Annie Huang, Drew Pratt, S. Steven Potter, Bruce R. Pawel, Paul A. Northcott
Publikováno v:
Neuro-Oncology. 22:785-796
Background Rhabdoid tumors (RTs) arise within (atypical teratoid/rhabdoid tumor [AT/RT]) or outside the brain (extra [e]CNS-RT) and are driven mainly by inactivation of the SWItch/sucrose nonfermentable (SWI/SNF) complex subunit SWI/SNF-related matri
Autor:
Arul M. Chinnaiyan, Derek Dang, Nicholas K. Foreman, Jill Bayliss, Karin M. Muraszko, Fusheng Yang, Martin P. Ogrodzinski, Sriram Venneti, Debra Hawes, Li Jiang, Siva Kumar Natarajan, Andrew M. Donson, Drew Pratt, Stefan Sweha, Javad Nazarian, Chan Chung, Benita Tamrazi, Christopher Dunham, Hugh J. L. Garton, Joanna J. Phillips, Jason Heth, Sophia Y. Lunt, Deepak Nagrath, Brendan Mullan, Marcin Cieslik, Jin Heon, Marcel Kool, Stefan Bluml, Chao Lu, Abhinav Achreja, Andrey Korshunov, C. David Allis, Benjamin R. Sabari, Miriam Bornhorst, Matthew Pun, Juliette Hukin, Pooja Panwalkar, Olamide Animasahun, Andrea Griesinger, Stefan M. Pfister, Richard J. Gilbertson, Mariella G. Filbin, Alexander R. Judkins, Stephen Yip, Carl Koschmann
Publikováno v:
Sci Transl Med
Science translational medicine, vol 13, iss 614
Science translational medicine, vol 13, iss 614
Childhood posterior fossa group A ependymomas (PFAs) have limited treatment options and bear dismal prognoses compared to group B ependymomas (PFBs). PFAs overexpress the oncohistone-like protein EZHIP (enhancer of Zeste homologs inhibitory protein),
With the growing recognition of the extent and prevalence of human cerebellar disorders, an understanding of developmental programs that build the mature cerebellum is necessary. In this chapter we present an overview of the basic epochs and key mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef87f846406a009337af25023797760
https://doi.org/10.1016/b978-0-444-63956-1.00002-3
https://doi.org/10.1016/b978-0-444-63956-1.00002-3