Identification of selective small molecule inhibitors of the nucleotide-binding oligomerization domain 1 (NOD1) signaling pathway.

Autor: David J Rickard, Clark A Sehon, Viera Kasparcova, Lorena A Kallal, Pamela A Haile, Xin Zeng, Monica N Montoute, Derek D Poore, Hu Li, Zining Wu, Patrick M Eidam, John G Emery, Robert W Marquis, Peter J Gough, John Bertin

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e96737 (2014)

NOD1 is an intracellular pattern recognition receptor that recognizes diaminopimelic acid (DAP), a peptidoglycan component in gram negative bacteria. Upon ligand binding, NOD1 assembles with receptor-interacting protein (RIP)-2 kinase and initiates a

Externí odkaz: https://doaj.org/article/d8966b29a270430a972aa590bfa33f4f

Development of a High-Throughput Cul3-Keap1 Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for Identifying Nrf2 Activators

Autor: Hu Li, Hongwei Qi, Brian Donovan, Ming Jiang, Derek D. Poore, Zining Wu, Michael Fischer, Subhas J. Chakravorty, Lawrence Wolfe, Thomas D. Sweitzer, Glenn A. Hofmann

Publikováno v: SLAS discovery : advancing life sciences RD. 24(2)

Nrf2, a master regulator of the phase II gene response to stress, is kept at low concentrations in the cell through binding to Keap1, an adaptor protein for the Cul3 ubiquitin ligase complex. To identify Nrf2 activators, two separate time-resolved fl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c412b192a8a78edb39df6756b4fcfa
https://pubmed.ncbi.nlm.nih.gov/30383469

Glutathione, S-substituted glutathiones, and leukotriene C4 as substrates for peptidylglycine α-amidating monooxygenase

Autor: David J. Merkler, Derek D Poore, Geoffrey H. Chew, Lamar Galloway, Kathleen A. Merkler, Cheol Hwan Yoon, Mitchell Anthony Delong, Advait S. Nagle, Kyung Woon Jung, Laura Aaron Miller, Laura E. Baumgart

Publikováno v: Archives of Biochemistry and Biophysics. 412:3-12

The C-terminal α-amide moiety of most peptide hormones arises by the posttranslational cleavage of a glycine-extended precursor in a reaction catalyzed by bifunctional peptidylglycine α-amidating monooxygenase (PAM). Glutathione and the S -alkylate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f123dccff20165c880e74c9b2b9322
https://doi.org/10.1016/s0003-9861(02)00730-0

Identification of Selective Small Molecule Inhibitors of the Nucleotide-Binding Oligomerization Domain 1 (NOD1) Signaling Pathway

Autor: Monica N. Montoute, Zining Wu, John G. Emery, Pamela A. Haile, Derek D. Poore, John Bertin, Peter J. Gough, Lorena A. Kallal, Clark A. Sehon, Xin Zeng, Hu Li, Viera Kasparcova, David J. Rickard, Robert W. Marquis, Patrick M. Eidam

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e96737 (2014)
PLoS ONE

NOD1 is an intracellular pattern recognition receptor that recognizes diaminopimelic acid (DAP), a peptidoglycan component in gram negative bacteria. Upon ligand binding, NOD1 assembles with receptor-interacting protein (RIP)-2 kinase and initiates a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96d24fca8dc4e5aa53be40d91246846
https://doi.org/10.1371/journal.pone.0096737

Lung tumor microphysiological system with 3D endothelium to evaluate modulators of T-cell migration.

Autor: Wisdom KM; In Vitro In Vivo Translation, Research, Pharmaceutical R&D, GSK, Collegeville, PA, USA., Suijker J; Mimetas B.V., Oegstgeest, The Netherlands., Van den Broek L; Mimetas B.V., Oegstgeest, The Netherlands., Sridharan B; In Vitro In Vivo Translation, Research, Pharmaceutical R&D, GSK, Collegeville, PA, USA., Grandhi TSP; In Vitro In Vivo Translation, Research, Pharmaceutical R&D, GSK, Collegeville, PA, USA., Cheng A; Genomic Sciences, Research, Pharmaceutical R&D, GSK, Collegeville, PA, USA., Lamb M; Genomic Sciences, Research, Pharmaceutical R&D, GSK, Stevenage, UK., Titus SA; Genomic Sciences, Research, Pharmaceutical R&D, GSK, Collegeville, PA, USA., Poore D; Immuno-Oncology, Research, Pharmaceutical R&D, GSK, Collegeville, PA, USA., Shah N; Immuno-Oncology, Research, Pharmaceutical R&D, GSK, Collegeville, PA, USA., Cheng SH; In Vitro In Vivo Translation, Research, Pharmaceutical R&D, GSK, Collegeville, PA, USA., Kim E; Immuno-Oncology, Research, Pharmaceutical R&D, GSK, Collegeville, PA, USA., Griffin S; Immuno-Oncology, Research, Pharmaceutical R&D, GSK, Stevenage, UK., Ekert J; In Vitro In Vivo Translation, Research, Pharmaceutical R&D, GSK, Collegeville, PA, USA.

Publikováno v: ALTEX [ALTEX] 2023; Vol. 40 (4), pp. 649-664. Date of Electronic Publication: 2023 Jun 16.