Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Derek D Sloan"'
Autor:
R Brad Jones, Stefanie Mueller, Rachel O'Connor, Katherine Rimpel, Derek D Sloan, Dan Karel, Hing C Wong, Emily K Jeng, Allison S Thomas, James B Whitney, So-Yon Lim, Colin Kovacs, Erika Benko, Sara Karandish, Szu-Han Huang, Maria J Buzon, Mathias Lichterfeld, Alivelu Irrinki, Jeffrey P Murry, Angela Tsai, Helen Yu, Romas Geleziunas, Alicja Trocha, Mario A Ostrowski, Darrell J Irvine, Bruce D Walker
Publikováno v:
PLoS Pathogens, Vol 12, Iss 4, p e1005545 (2016)
Resting CD4+ T-cells harboring inducible HIV proviruses are a critical reservoir in antiretroviral therapy (ART)-treated subjects. These cells express little to no viral protein, and thus neither die by viral cytopathic effects, nor are efficiently c
Externí odkaz:
https://doaj.org/article/8d9eef0385234f16ae9fba721f3491fb
Autor:
Derek D Sloan, Chia-Ying Kao Lam, Alivelu Irrinki, Liqin Liu, Angela Tsai, Craig S Pace, Jasmine Kaur, Jeffrey P Murry, Mini Balakrishnan, Paul A Moore, Syd Johnson, Jeffrey L Nordstrom, Tomas Cihlar, Scott Koenig
Publikováno v:
PLoS Pathogens, Vol 11, Iss 11, p e1005233 (2015)
HIV reservoirs and production of viral antigens are not eliminated in chronically infected participants treated with combination antiretroviral therapy (cART). Novel therapeutic strategies aiming at viral reservoir elimination are needed to address c
Externí odkaz:
https://doaj.org/article/b748f788913f41528226c5ca0c716a56
Autor:
Francis Hong, Derek D. Sloan, Jeffrey P. Murry, Jasmine Kaur, Mattie Follen, Alivelu Irrinki, Sandra S. Win, John W. Mellors, Romas Geleziunas, Angela Tsai, Tomas Cihlar, Anthony R. Cillo
Publikováno v:
AIDS (London, England). 32(6)
OBJECTIVE To define the relationships between molecular measures of viral persistence in blood (i.e., plasma viremia, cellular HIV-1 DNA, and mRNA) and expressed or inducible virus from resting CD4 T cells of individuals on suppressive antiretroviral
Autor:
Derek D. Sloan, Roselyn J. Eisenberg, Padmaja Tummala, Michael T Hensel, Jason D. Marshall, Darren S. Heeke, Eileen Rao, Michael R Dorwart, Gary H. Cohen, Li Yu
Several prophylactic vaccines targeting herpes simplex virus 2 (HSV-2) have failed in the clinic to demonstrate sustained depression of viral shedding or protection from recurrences. Although these vaccines have generated high titers of neutralizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75276a45dbd801a696c7aae5187fab2
https://europepmc.org/articles/PMC5391472/
https://europepmc.org/articles/PMC5391472/
Autor:
Jeffrey P. Murry, Alivelu Irrinki, Tomas Cihlar, Jasmine Kaur, Derek D. Sloan, Angela Tsai, George Kukolj
Publikováno v:
Journal of Virology
Antiretroviral therapy can suppress HIV replication to undetectable levels but does not eliminate latent HIV, thus necessitating lifelong therapy. Recent efforts to target this persistent reservoir have focused on inducing the expression of latent HI
Autor:
Jeffrey P. Murry, Angela Tsai, Stefanie Mueller, James B. Whitney, R. Brad Jones, So-Yon Lim, Erika Benko, Helen Yu, Rachel O’Connor, Alicja Trocha, Hing C. Wong, Szu-Han Huang, Colin Kovacs, Alivelu Irrinki, Emily K. Jeng, Allison S. Thomas, Derek D. Sloan, Katherine Rimpel, Bruce D. Walker, Mario A. Ostrowski, Sara Karandish, Maria J. Buzon, Romas Geleziunas, Darrell J. Irvine, Dan Karel, Mathias Lichterfeld
Publikováno v:
PLoS Pathogens, Vol 12, Iss 4, p e1005545 (2016)
PLoS Pathogens
Public Library of Science
PLoS Pathogens
Public Library of Science
Resting CD4⁺ T-cells harboring inducible HIV proviruses are a critical reservoir in antiretroviral therapy (ART)-treated subjects. These cells express little to no viral protein, and thus neither die by viral cytopathic effects, nor are efficiently
Autor:
Keith R. Jerome, Derek D. Sloan
Publikováno v:
Journal of Virology. 81:12504-12514
Herpes simplex virus (HSV)-specific T cells are essential for viral clearance. However, T cells do not prevent HSV latent infection or reactivation, suggesting that HSV has the potential to modulate T-cell function. T-cell receptor (TCR) stimulation
Autor:
Martine Aubert, Sara A. Miller, Derek D. Sloan, Chung H. Dang, Jin Young Han, Keith R. Jerome
Publikováno v:
Virology. 359:253-263
T cells are an essential component of the immune response against herpes simplex virus (HSV) infection. We previously reported that incubation of T cells with HSV-infected fibroblasts inhibits subsequent T cell antigen receptor signal transduction. I
Publikováno v:
Apoptosis. 8:563-571
Cytotoxic T lymphocytes (CTL) are critical effector cells of the immune system. Measurement of target cell damage has historically been an important measure of CTL function. CTL kill their target cells predominantly by inducing programmed cell death,
Autor:
Scott H Robbins, Semih U. Tareen, James M. Allen, Jared M. Odegard, Brenna Kelley-Clarke, Derek D. Sloan, Neal Van Hoeven, Megan M. Slough, Linda A Cassiano, Lisa T. Nelson, Thomas W. Dubensky, Christopher J. Nicolai, Chintan D. Vin
As sentinels of the immune system, dendritic cells (DCs) play an essential role in regulating cellular immune responses. One of the main challenges of developing DC-targeted therapies includes the delivery of antigen to DCs in order to promote the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04913bc07bc8f757b99c7cf84c1e6896
https://europepmc.org/articles/PMC3944334/
https://europepmc.org/articles/PMC3944334/