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pro vyhledávání: '"Derek Cousineau"'
Autor:
Neal K. Bennett, Mai K. Nguyen, Maxwell A. Darch, Hiroki J. Nakaoka, Derek Cousineau, Johanna ten Hoeve, Thomas G. Graeber, Markus Schuelke, Emin Maltepe, Martin Kampmann, Bryce A. Mendelsohn, Jean L. Nakamura, Ken Nakamura
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Energy metabolism and ATP levels are controlled by an interlocking network of pathways. Here, the authors apply a genome-wide CRISPR screen to define genes that increase or decrease ATP levels to define the “ATPome”, a map of pathways that contri
Externí odkaz:
https://doaj.org/article/f277e255c7dc4504b568ae47fe3e9af8
Autor:
Martin Kampmann, Markus Schuelke, Johanna ten Hoeve, Bryce A. Mendelsohn, Jean L. Nakamura, Mai K. Nguyen, Maxwell A. Darch, Thomas G. Graeber, Emin Maltepe, Derek Cousineau, Ken Nakamura, Hiroki J. Nakaoka, Neal K. Bennett
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature communications, vol 11, iss 1
Disrupted energy metabolism drives cell dysfunction and disease, but approaches to increase or preserve ATP are lacking. To generate a comprehensive metabolic map of genes and pathways that regulate cellular ATP—the ATPome—we conducted a genome-w