Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Derek C. Rogers"'
Autor:
Lesley J. Rooke, John A. Curtin, Nigel K. Spurr, Ian C. Gray, Jo Peters, Ian D. Latham, JE Martin, Elizabeth M. C. Fisher, Lucie Vizor, Sohaila Rastan, Steve D.M. Brown, Derek C. Rogers, Vicky Tsipouri, A. Jackie Hunter, Claire A. Parsons, Colin M. Clapham, P Nolan
Publikováno v:
Comparative and Functional Genomics, Vol 5, Iss 2, Pp 123-127 (2004)
Comparative and Functional Genomics
Comparative and Functional Genomics
Three mutant mice with pigmentation phenotypes were recovered from a genomewide random mouse chemical mutagenesis study. White toes (Whto; MGI:1861986), Belly spot and white toes (Bswt; MGI:2152776) and Dark footpads 2 (Dfp2; MGI:1861991) were identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4855d7b9e8a215f46544578225b122d
https://doaj.org/article/3cb652a5fa51480fb8aa6345a8775d99
https://doaj.org/article/3cb652a5fa51480fb8aa6345a8775d99
Autor:
A. J. Hunter, Jane E. Cluderay, J. Latcham, Christian Heidbreder, Pippa L Pugh, Jon T. Brown, Charlie Reavill, Lee A. Dawson, Ceri H. Davies, Evelyn Grau, Susan J. Pickering, G Brown, Claire S. Shilliam, Barry Crook, A Howarth, Panida Hemmati, Zoe A. Hughes, Derek C. Rogers, Guillaume J. Hervieu, Stephen M. Harrison, Peter R. Maycox
Publikováno v:
Molecular and Cellular Neuroscience. 24:1170-1179
Several psychiatric diseases, including schizophrenia, are thought to have a developmental aetiology, but to date no clear link has been made between psychiatric disease and a specific developmental process. LPA1 is a Gi-coupled seven transmembrane r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f5ca71824413304196e63bb4298e03
https://doi.org/10.1016/j.mcn.2003.09.001
https://doi.org/10.1016/j.mcn.2003.09.001
Autor:
Douglas R Smith, Warren D. Hirst, Derek C. Rogers, Neil Upton, Mark S. Duxon, Nigel Deeks, Sarah Bartlett, Graham J. Riley, Tania O. Stean, David R. Thomas, Gary W. Price, Steven Mark Bromidge, Halina T Serafinowska
Publikováno v:
Pharmacology Biochemistry and Behavior. 71:645-654
N -(2,5-Dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134) potently inhibited [ 125 I]SB-258585 and [ 3 H]LSD binding in a HeLa cell line expressing human 5-HT 6 receptors (p K i =8.6 and 8.54, respectively). Furthermore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2141213f563d15a02070c4ab6b5b8a4
https://doi.org/10.1016/s0091-3057(01)00742-0
https://doi.org/10.1016/s0091-3057(01)00742-0
Autor:
Philip T. Davey, Melanie J Sammons, Andrew A. Parsons, Derek C. Rogers, Sharon Bingham, Pravin Raval
Publikováno v:
Brain Research. 876:48-54
NGF is an important link between inflammation and hyperalgesia and interacts with many different mediators of inflammation, including the MAPK signaling pathway. In these studies, carrageenan-induced thermal hyperalgesia was evaluated in the mouse an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd66d79a6afeb8f2a53213a669b865c
https://doi.org/10.1016/s0006-8993(00)02596-8
https://doi.org/10.1016/s0006-8993(00)02596-8
Autor:
Philomena Mburu, Joanne E. Martin, Simon Greenaway, Josephine Peters, Mark A. Strivens, Ian C. Gray, P. Roby, Jean-Louis Guénet, Patrick M. Nolan, Carole D. Nickols, Stéphanie Voegeling, Xue Zhong Liu, R Selley, Adrian M. Isaacs, Stefan L. McCormack, Elizabeth M. C. Fisher, C Thornton, M Browne, Alexandra Erven, Ruth M. Arkell, Tertius Hough, Zuzanna Tymowska-Lalanne, Jackie Hunter, Karen P. Steel, Peter H. Glenister, Kay E. Davies, Rachel E. Hardisty, D Brooker, R Sadri, Nigel K. Spurr, E Whitehill, Lucie Vizor, J A Stevenson, K Pickford, Christine A. Wells, Amy E. Kiernan, M Hewitt, Steve D.M. Brown, Sohaila Rastan, Derek C. Rogers, Caroline Thaung, Jim J. Hagan, R Washbourne, M Nasse
Publikováno v:
Nature Genetics. 25:440-443
As the human genome project approaches completion, the challenge for mammalian geneticists is to develop approaches for the systematic determination of mammalian gene function. Mouse mutagenesis will be a key element of studies of gene function. Phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d69b10742c4b2938bb2e4430adf5d1
https://doi.org/10.1038/78140
https://doi.org/10.1038/78140
Publikováno v:
Stroke. 28:2060-2066
Background and Purpose There have been a number of recent reports describing the relationship between ischemic damage and various behavioral and functional measures, although there have been few studies that have demonstrated a direct correlation bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d078004ff0c9df7bc14abab02a35796d
https://doi.org/10.1161/01.str.28.10.2060
https://doi.org/10.1161/01.str.28.10.2060
Autor:
A. Jackie Hunter, Derek C. Rogers
Publikováno v:
Pharmacology Biochemistry and Behavior. 56:747-754
Photochemical induction of a thrombosis produces lesions of the cortex of reproducible area and depth, and it has been suggested that this may provide a relatively noninvasive model of the human condition of stroke. The cognitive effects of photothro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4da78aca83780fd9915fea40636937e
https://doi.org/10.1016/s0091-3057(96)00430-3
https://doi.org/10.1016/s0091-3057(96)00430-3
Autor:
Derek C. Rogers, Dalip J. S. Sirinathsinghji, Stephen B. Dunnett, L. E. Annett, Eduardo Miguel Torres
Publikováno v:
Neuroscience Letters. 150:29-32
We have observed in the basal forebrain of the common marmoset a group of neurones which display tyrosine hydroxylase immunoreactivity (THir) with three different polyclonal antibodies and one monoclonal antibody, and which express TH mRNA as shown b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e0d0e6c873ce7004eab9133db0b82b
https://doi.org/10.1016/0304-3940(93)90100-y
https://doi.org/10.1016/0304-3940(93)90100-y
Autor:
Graham J. Riley, Neil Upton, Lee A. Dawson, Douglas R Smith, Christian Heidbreder, Ciaran M. Regan, Tania O. Stean, David Sunter, Alan R. Atkins, Warren D. Hirst, Andrew G. Foley, Steven Mark Bromidge, Pippa L Pugh, Stephen Frederik SmithKline Beecham Phar Moss, Sarah Bartlett, Derek C. Rogers, Laurent P. Lacroix
Publikováno v:
European journal of pharmacology. 553(1-3)
SB-399885 (N-[3,5-dichloro-2-(methoxy)phenyl]-4-(methoxy)-3-(1-piperazinyl)benzenesulfonamide) has high affinity for human recombinant and native 5-HT(6) receptors, with pK(i) values 9.11+/-0.03 and 9.02+/-0.05, respectively and is a potent competiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e5f0f38a3c35d5b55abd4f9d6b3512
https://pubmed.ncbi.nlm.nih.gov/17069795
https://pubmed.ncbi.nlm.nih.gov/17069795
Autor:
Josephine Peters, Zuzanna Tymowska-Lalanne, R Selley, Lucie Vizor, M. Bouzyk, Sohaila Rastan, Karen P. Steel, Nigel K. Spurr, Rachel E. Hardisty, A. Kierman, Charlie Reavill, Derek C. Rogers, David P. Kelsell, A. J. Hunter, C Thornton, Simon Greenaway, S. McCormick, Christine A. Wells, Steve D.M. Brown, Tertius Hough, Ian C. Gray, Mark A. Strivens, Joanne E. Martin, Philomena Mburu, Jean-Louis Guénet, I. C. Gray, Steven A. Sheardown, Elizabeth M. C. Fisher, P Nolan, Alexandra Erven, S. Voeling, R Washbourne, Jim J. Hagan, Adrian M. Isaacs, H. Tsai, Kay E. Davies, P. Roby, M Hewitt, Peter H. Glenister
Publikováno v:
Genetica. 122(1)
With the completion of the first draft of the human genome sequence, the next major challenge is assigning function to genes. One approach is genome-wide random chemical mutagenesis, followed by screening for mutant phenotypes of interest and subsequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec5906b3275e88bb89870e2d9c0bc02
https://pubmed.ncbi.nlm.nih.gov/15619960
https://pubmed.ncbi.nlm.nih.gov/15619960