Výsledky vyhledávání - "Derek C Radisky"

Akademický článek

Lattice-based model of ductal carcinoma in situ suggests rules for breast cancer progression to an invasive state.

Autor: Eline Boghaert, Derek C Radisky, Celeste M Nelson

Publikováno v: PLoS Computational Biology, Vol 10, Iss 12, p e1003997 (2014)

Ductal carcinoma in situ (DCIS) is a heterogeneous group of non-invasive lesions of the breast that result from abnormal proliferation of mammary epithelial cells. Pathologists characterize DCIS by four tissue morphologies (micropapillary, cribriform

Externí odkaz: https://doaj.org/article/42ce778403744c218887341935d7a13d

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Akademický článek

An integrated model of the transcriptome of HER2-positive breast cancer.

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e79298 (2013)

Our goal in these analyses was to use genomic features from a test set of primary breast tumors to build an integrated transcriptome landscape model that makes relevant hypothetical predictions about the biological and/or clinical behavior of HER2-po

Externí odkaz: https://doaj.org/article/b4f7343083b74f57913c4b514a195e31

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Akademický článek

PEGylation extends circulation half-life while preserving in vitro and in vivo activity of tissue inhibitor of metalloproteinases-1 (TIMP-1).

Autor: Jyotica Batra, Jessica Robinson, Christine Mehner, Alexandra Hockla, Erin Miller, Derek C Radisky, Evette S Radisky

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e50028 (2012)

Excess proteolytic activity of matrix metalloproteinases (MMPs) contributes to the development of arthritis, cardiovascular diseases and cancer progression, implicating these enzymes as therapeutic targets. While many small molecule inhibitors of MMP

Externí odkaz: https://doaj.org/article/3c3cbb103e984d14a89493ad8be73394

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Akademický článek

249 Defining the Role of Hedgehog Signaling in Breast Cancer Risk of non-Hispanic Black Women

Autor: Savanna A. Toure, Melody L. Stallings, Joshua W. Ogony, Laura M. Pacheco-Spann, Mark E. Sherman, Derek C. Radisky

Publikováno v: Journal of Clinical and Translational Science, Vol 8, Pp 75-75 (2024)

OBJECTIVES/GOALS: The molecular basis of increased risk of triple negative breast cancer in non-Hispanic Black women represents a critical knowledge gap that this research is designed to address; successful completion of this work could lead to bette

Externí odkaz: https://doaj.org/article/0695ae0fcb564c01a7883965a6ac8d3d

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Akademický článek

Towards defining morphologic parameters of normal parous and nulliparous breast tissues by artificial intelligence

Publikováno v: Breast Cancer Research, Vol 24, Iss 1, Pp 1-11 (2022)

Abstract Background Breast terminal duct lobular units (TDLUs), the source of most breast cancer (BC) precursors, are shaped by age-related involution, a gradual process, and postpartum involution (PPI), a dramatic inflammatory process that restores

Externí odkaz: https://doaj.org/article/07ab4358e8464168b7626e45f6eceb5e

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Benign Breast Disease, NSAIDs, and Postmenopausal Breast Cancer Risk in the CPS-II Cohort

Autor: Mark E. Sherman, Robert A. Vierkant, Matthew Masters, Derek C. Radisky, Stacey J. Winham, Amy C. Degnim, Celine M. Vachon, Alpa V. Patel, Lauren R. Teras

Publikováno v: Cancer Prevention Research. 16:175-184

Nonsteroidal anti-inflammatory agents (NSAID) are associated with modest inconsistent reductions in breast cancer risk in population-based cohorts, whereas two focused studies of patients with benign breast disease (BBD) have found lower risk with NS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6320ecce909dd191b6996ad05558f05
https://doi.org/10.1158/1940-6207.capr-22-0403

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Aberrant TIMP-1 overexpression in tumor-associated fibroblasts drives tumor progression through CD63 in lung adenocarcinoma

Autor: Paula Duch, Natalia Díaz-Valdivia, Rafael Ikemori, Marta Gabasa, Evette S. Radisky, Marselina Arshakyan, Sabrina Gea-Sorlí, Anna Mateu-Bosch, Paloma Bragado, Josep Lluís Carrasco, Hidetoshi Mori, Josep Ramírez, Cristina Teixidó, Noemí Reguart, Cristina Fillat, Derek C. Radisky, Jordi Alcaraz

Publikováno v: Matrix Biology. 111:207-225

Tissue inhibitor of metalloproteinase-1 (TIMP-1) is an important regulator of extracellular matrix turnover that has been traditionally regarded as a potential tumor suppressor owing to its inhibitory effects of matrix metalloproteinases. Intriguingl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43154087079bd31b46b04a40bf5dc03d
https://doi.org/10.1016/j.matbio.2022.06.009

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