Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Derek Brocksmith"'
Autor:
David T. White, Naijia Huang, Jeffrey S. Tan, Kenneth J. Ruterbories, Jason Liu, Derek Brocksmith, Lee J. Burns, Alain Stricker-Krongrad, Nathan Yumibe, Nita J. Patel, Guy Bouchard
Publikováno v:
International Journal of Pharmacokinetics. 2:81-91
Aim: Oral and intravenous pharmacokinetic (PK) studies were conducted in four different minipig strains: Sinclair, Yucatan, Hanford and Göttingen after administration of metformin or R,S-verapamil (R,S-VER). Results: The results indicated that the P
Autor:
Chris Hanks, Shayne C. Gad, Jason Liu, Amber Fuller, Derek Brocksmith, Miao Zhong, Guy Bouchard, Catherine Shoemake, David T. White, Alain Stricker-Krongrad
Publikováno v:
International Journal of Toxicology. 36:113-123
A functional observational battery (FOB) is recommended as the first-tier neurotoxicity screening in the preclinical safety pharmacology testing guidelines. Minipigs have increasingly been used in regulatory toxicology studies; however, no current FO
Autor:
Shayne C. Gad, Marcia E. Pereira, Guy Bouchard, Catherine Shoemake, Alain Stricker-Krongrad, Derek Brocksmith
Publikováno v:
Toxicologic Pathology. 44:421-427
The use of miniature swine as a nonrodent species in safety assessment has continued to expand for over a decade, and they are becoming routinely used in toxicology and in pharmacology as well as a model for human diseases. Miniature swine models are
Autor:
Alain Stricker-Krongrad, Catherine Shoemake, Derek Brocksmith, Jason Liu, Robert Hamlin, Guy Bouchard
Publikováno v:
Toxicology Research and Application, Vol 1 (2017)
The minipig has been increasingly recognized as a valid alternative to canines and nonhuman primates in regulatory toxicity. This article presents the results of cardiovascular assessments in the Yucatan, Hanford, Sinclair, and Göttingen minipigs co
Autor:
Nicole Navratil, Melanie A. Greeley, Kristi L. Helke, Vimala Vemireddi, Sean McKeag, Binod Jacob, Alain Stricker-Krongrad, Keith N. Nelson, Julius Haruna, Charlotte Hollinger, Aaron M. Sargeant, Derek Brocksmith
Publikováno v:
Toxicologic pathology. 44(3)
Swine, especially the miniature swine or minipigs, are increasingly being used in preclinical safety assessment of small molecules, biopharmaceutical agents, and medical devices as an alternate nonrodent species. Although swine have been used extensi
Autor:
Guy Bouchard, Alain Stricker-Krongrad, Robert L. Hamlin, Derek Brocksmith, Catherine Shoemake, Jason Liu
Publikováno v:
Toxicology Research and Application. 1:239784731769636
The minipig has been increasingly recognized as a valid alternative to canines and nonhuman primates in regulatory toxicity. This article presents the results of cardiovascular assessments in the Yucatan, Hanford, Sinclair, and Göttingen minipigs co