Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Derek Barclay"'
Publikováno v:
Frontiers in Systems Biology, Vol 4 (2024)
IntroductionPediatric Acute Liver Failure (PALF) presents as a rapidly evolving, multifaceted, and devastating clinical syndrome whose precise etiology remains incompletely understood. Consequently, predicting outcomes—whether survival or mortality
Externí odkaz:
https://doaj.org/article/3e1bb658158247bc9329dacfd2e15c34
Autor:
Ashti M. Shah, Ruben Zamora, Derek Barclay, Jinling Yin, Fayten El-Dehaibi, Meghan Addorisio, Tea Tsaava, Aisling Tynan, Kevin Tracey, Sangeeta S. Chavan, Yoram Vodovotz
Publikováno v:
Frontiers in Systems Biology, Vol 4 (2024)
Introduction: The vagus nerve innervates multiple organs, but its role in regulating cross-tissue spread of inflammation is as yet unclear. We hypothesized that the vagus nerve may regulate cross-tissue inflammation via modulation of the putatively n
Externí odkaz:
https://doaj.org/article/496c8d0e4a73410d9d08b91bf0ee8b3b
Autor:
Rami A. Namas, Maxim Mikheev, Jinling Yin, Derek Barclay, Bahiyyah Jefferson, Qi Mi, Timothy R. Billiar, Ruben Zamora, Jorg Gerlach, Yoram Vodovotz
Publikováno v:
Frontiers in Systems Biology, Vol 2 (2023)
Introduction: Systemic acute inflammation accompanies and underlies the pathobiology of sepsis but is also central to tissue healing. We demonstrated previously the in vivo feasibility of modulating the key inflammatory mediator tumor necrosis factor
Externí odkaz:
https://doaj.org/article/087deabccc294d3aa300bcd9a3fb6b09
Autor:
Nabil Azhar, Rami A. Namas, Khalid Almahmoud, Akram Zaaqoq, Othman A. Malak, Derek Barclay, Jinling Yin, Fayten El-Dehaibi, Andrew Abboud, Richard L. Simmons, Ruben Zamora, Timothy R. Billiar, Yoram Vodovotz
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Systemic inflammation is complex and likely drives clinical outcomes in critical illness such as that which ensues following severe injury. We obtained time course data on multiple inflammatory mediators in the blood of blunt trauma patients
Externí odkaz:
https://doaj.org/article/eaee90484a5b42d6b93c66d1d070bc50
Autor:
Ashti M. Shah, Ruben Zamora, Sebastian Korff, Derek Barclay, Jinling Yin, Fayten El-Dehaibi, Timothy R. Billiar, Yoram Vodovotz
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Trauma/hemorrhagic shock followed by resuscitation (T/HS-R) results in multi-system inflammation and organ dysfunction, in part driven by binding of damage-associated molecular pattern molecules to Toll-like Receptor 4 (TLR4). We carried out experime
Externí odkaz:
https://doaj.org/article/76aaa9a2df454cf7a6786842a8803f07
Autor:
Ali Mubin Aral, Ruben Zamora, Derek Barclay, Jinling Yin, Fayten El-Dehaibi, Vasil E. Erbas, Liwei Dong, Zhaoxiang Zhang, Huseyin Sahin, Vijay S. Gorantla, Yoram Vodovotz
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Systems-level insights into inflammatory events after vascularized composite allotransplantation (VCA) are critical to the success of immunomodulatory strategies of these complex procedures. To date, the effects of tacrolimus (TAC) immunosuppression
Externí odkaz:
https://doaj.org/article/07aa1e49e1a945ebaa55d340213ab5f5
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
The Pediatric Acute Liver Failure (PALF) study is a multicenter, observational cohort study of infants and children diagnosed with this complex clinical syndrome. Outcomes in PALF reflect interactions among the child’s clinical condition, response
Externí odkaz:
https://doaj.org/article/c111c58a6e70401b8bfdfda426ff0228
Autor:
Lukas Schimunek, Haley Lindberg, Maria Cohen, Rami A. Namas, Qi Mi, Jinling Yin, Derek Barclay, Fayten El-Dehaibi, Andrew Abboud, Ruben Zamora, Timothy Robert Billiar, Yoram Vodovotz
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Systemic inflammation ensues following traumatic injury, driving immune dysregulation and multiple organ dysfunction (MOD). While a balanced immune/inflammatory response is ideal for promoting tissue regeneration, most trauma patients exhibit variabl
Externí odkaz:
https://doaj.org/article/47a5bf8f328d42819b0b0f381a9e8e1a
Autor:
Lukas Schimunek, Rami A. Namas, Jinling Yin, Derek Barclay, Dongmei Liu, Fayten el-Dehaibi, Andrew Abboud, Maria Cohen, Ruben Zamora, Timothy R. Billiar, Yoram Vodovotz
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Trauma is a leading cause of morbidity and mortality. It is unclear why some trauma victims follow a complicated clinical course and die, while others, with apparently similar injury characteristics, do not. Interpatient genomic differences, in the f
Externí odkaz:
https://doaj.org/article/6fb0e64f2e3c4b7383c5b79717dfc222
Diurnal Variation in Systemic Acute Inflammation and Clinical Outcomes Following Severe Blunt Trauma
Autor:
Akram M. Zaaqoq, Rami A. Namas, Othman Abdul-Malak, Khalid Almahmoud, Derek Barclay, Jinling Yin, Ruben Zamora, Matthew R. Rosengart, Timothy R. Billiar, Yoram Vodovotz
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Animal studies suggest that the time of day is a determinant of the immunological response to both injury and infection. We hypothesized that due to this diurnal variation, time of injury could affect the systemic inflammatory response and outcomes p
Externí odkaz:
https://doaj.org/article/acaade017e1b4a0db49f462127fef377