Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Derek Alexander Weddell"'
Autor:
Michael Prime, Samantha Green, Celia Dominguez, Edith Monteagudo, Malcolm Taylor, Akihiro Takano, Longbin Liu, Adrian Kotey, Wayne Thomas, Zhisheng Jia, Anthony P Dickie, Catherine Greenaway, Samuel Coe, Miklós Tóth, John Wityak, Vinod Khetarpal, Sergio Menta, Simone Esposito, Katarina Vanräs, Andreas Ebneth, John E. Mangette, Ian Wigginton, Todd Herbst, Peter Johnson, Sabine Schaertl, Vladimir Stepanov, Jonathan Bard, Sebastien Galan, Elise Gadouleau, Randall Davis, Christopher John Brown, Frank Herrmann, Richard W Marston, Darshan Gunvant Vaidya, Laura Orsatti, Xuemei Chen, Martina Nibbio, Manuela Heßmann, Joanne Sproston, Matthew R Mills, Ignacio Munoz-Sanjuan, Daniel Clark-Frew, Derek Alexander Weddell, Ladislav Mrzljak, Christoph Scheich, Xinjie Gai, Christer Halldin, Sangram Nag, Lee Matthew, Patricia Miranda-Azpiazu, Paul Giles, Thomas Krulle, Alexander Kiselyov, Marie Svedberg, Sarah Hayes
Publikováno v:
Journal of medicinal chemistry. 63(15)
Mutant huntingtin (mHTT) protein carrying the elongated N-terminal polyglutamine (polyQ) tract misfolds and forms protein aggregates characteristic of Huntington's disease (HD) pathology. A high-affinity ligand specific for mHTT aggregates could serv
Autor:
Florian Krieger, Stephen Martin Courtney, Mark J. Gemkow, Jordan Palfrey, Hyunsun Park, Derek Alexander Weddell, Sabine Schaertl, Michel Maillard, Celia Dominguez, Ignacio Munoz-Sanjuan, Taylor Malcolm, Florence M. Eustache, Frederick Arthur Brookfield, Rebecca K. Handel, Laura C. Johnson, Peter Johnson, Mark Kerry, Mirco Meniconi
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:5833-5851
Several caspases have been implicated in the pathogenesis of Huntington’s disease (HD); however, existing caspase inhibitors lack the selectivity required to investigate the specific involvement of individual caspases in the neuronal cell death ass
Autor:
Leticia Toledo-Sherman, Catherine M. O'Connell, Christopher John Yarnold, Michael Prime, Suganathan Selvaratnam, Ignacio Munoz-Sanjuan, Ladislav Mrzljak, Arash Rassoulpour, Kimberly L Matthews, Patricia Wheelan, Laura Reed, Wolfgang Reindl, Alan Beresford, Estelle Hamelin-Flegg, Derek Alexander Weddell, William L. Mitchell, Dawn Yates, Maria Beconi, Weslyn Ward Friley, Christopher John Brown, Christin Winkler, Stephen Martin Courtney, Valerie Kempf, John Wityak, Naomi Went, Celia Dominguez, Isabell Cardaun, Kendall D. Powell, Ulrike Dijkman, Peter Johnson, Frederick Arthur Brookfield, Dirk Winkler, De Aguiar Pena Paula C, Kathy Lyons
Publikováno v:
Journal of medicinal chemistry. 58(3)
We report on the development of a series of pyrimidine carboxylic acids that are potent and selective inhibitors of kynurenine monooxygenase and competitive for kynurenine. We describe the SAR for this novel series and report on their inhibition of K