Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Derek A. Schreihofer"'
Autor:
Anthony Oppong-Gyebi, Daniel Metzger, Philip H. Vann, R. Andrew Yockey, Nathalie Sumien, Derek A. Schreihofer
Publikováno v:
Hormones and behavior. 144
Genistein possesses estrogenic activity and has been considered a potential replacement for estrogen replacement therapy after menopause. In the current study, we investigated the neuroprotective effects of dietary genistein at varied lengths of estr
Autor:
Nathalie Sumien, Jordan Han, Derek A. Schreihofer, Phillip H Vann, R. Andrew Yockey, Daniel B. Metzger, Trinh Doan, Anthony Oppong-Gyebi
Publikováno v:
Journal of neuroscience researchREFERENCES. 100(2)
Increasing age disproportionately increases the risk of stroke among women compared to men of similar age, especially after menopause. One of the reasons for this observation is a sharp drop in circulating estrogens. However, the timing of initiation
Publikováno v:
J Pharmacol Toxicol Methods
The Sigma-1 receptor (S1R) is an endoplasmic reticulum (ER) chaperone protein that has been implicated in attenuating inflammatory stress-mediated brain injuries. Selective S1R agonists represent a new class of therapeutic agent for treating neuropsy
Publikováno v:
Steroids. 133:15-20
Sex steroid receptors act as ligand activated nuclear transcription factors throughout the body, including the brain. However, post-translational modification of these receptors can direct them to extranuclear sites, including the plasma membrane, wh
Autor:
Rebecca L. Cunningham, Phong Duong, E Nicole Wilson, Brina Snyder, Derek A. Schreihofer, Marc T Anderson Ph.D., Jenny Trieu
Publikováno v:
Physiology & Behavior. 189:64-73
Sleep apnea is a common sleep disorder characterized by intermittent periods of low blood oxygen levels. The risk for sleep apnea increases with age and is more prevalent in men than women. A common comorbidity of sleep apnea includes male sexual dys
Autor:
Ella A. Kasanga, Philip H. Vann, Daniel B. Metzger, Rebecca L. Cunningham, Derek A. Schreihofer, Nathalie Sumien, Jessica M. Wong, Anthony Oppong-Gyebi, Jo Contreras-Garza, Charity Smith
Publikováno v:
Neuroendocrinology. 110(11-12)
Introduction: An increasing number of middle-aged men are being screened for low testosterone levels and the number of prescriptions for various forms of testosterone replacement therapy (TRT) has increased dramatically over the last 10 years. Howeve
Publikováno v:
Nutritional neuroscience. 22(6)
Genistein is a plant estrogen promoted as an alternative to post-menopausal hormone therapy because of a good safety profile and its promotion as a natural product. Several preclinical studies of cerebral ischemia and other models of brain injury sup
Publikováno v:
Brain research bulletin. 134
Tremendous efforts and funds invested in discovery of novel drug treatments for ischemic stroke have so far failed to deliver clinically efficacious therapies. The reasons for these failures are not fully understood. An indiscriminate use of isoflura
Autor:
Earl W. Stradtman, Hyung Goo Kim, Yiping Shen, Samuel D. Quaynor, Lawrence C. Layman, Lynn P. Chorich, Derek A. Schreihofer
Publikováno v:
New England Journal of Medicine. 369:164-171
Although androgen resistance has been characterized in men with a normal chromosome complement and mutations in the androgen-receptor gene, a mutation in the gene encoding estrogen receptor α (ESR1) was previously described only in one man and not,
Autor:
Yulin Ma, Derek A. Schreihofer
Publikováno v:
Brain Research. 1514:107-122
Estrogens, particularly 17β-estradiol (E2), are powerful neuroprotective agents in animal models of cerebral ischemia. Loss of endogenous E2 in women at menopause or after surgical oopherectomy leads to an increase risk of stroke, neurodegenerative