Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Derek A. Nichols"'
Autor:
Daniel R. Dempsey, Derek A. Nichols, Matthew R. Battistini, Orville Pemberton, Santiago Rodriguez Ospina, Xiujun Zhang, Anne-Marie Carpenter, Brian G. O’Flynn, James W. Leahy, Ankush Kanwar, Eric M. Lewandowski, Yu Chen, David J. Merkler
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Agmatine N-acetyltransferase (AgmNAT) catalyzes the formation of N-acetylagmatine from acetyl-CoA and agmatine. Herein, we provide evidence that Drosophila melanogaster AgmNAT (CG15766) catalyzes the formation of N-acetylagmatine using an or
Externí odkaz:
https://doaj.org/article/b2083b0e3aaf4cd49387f1ef030550cb
Autor:
Yu Chen, Adam R. Renslo, M. Trent Kemp, Insung Na, Xiujun Zhang, Kyle DeFrees, Derek A. Nichols
Publikováno v:
FEBS Letters. 595:2981-2994
The Asp233-Asp246 pair is highly conserved in Class A β-lactamases, which hydrolyze β-lactam antibiotics. Here, we characterize its function using CTX-M-14 β-lactamase. The D233N mutant displayed decreased activity that is substrate-dependent, wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b7dcd70f060259df6f6764a170cf260
https://doi.org/10.1002/1873-3468.14215
https://doi.org/10.1002/1873-3468.14215
Publikováno v:
AIAA SCITECH 2022 Forum.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02fd7dec2188c90bf6cb13fb32b2b3de
https://doi.org/10.2514/6.2022-1698
https://doi.org/10.2514/6.2022-1698
Publikováno v:
Athletic Training & Sports Health Care. 11:10-18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db6ce9ad00933d73a0b8c6a629f41d29
https://doi.org/10.3928/19425864-20180509-01
https://doi.org/10.3928/19425864-20180509-01
Publikováno v:
AIAA Scitech 2021 Forum.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71cac05f430f7f8663dc4fadf5401972
https://doi.org/10.2514/6.2021-1556
https://doi.org/10.2514/6.2021-1556
Publikováno v:
AIAA AVIATION 2020 FORUM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9344c85e7b4fcbdff65d2fb5f555db98
https://doi.org/10.2514/6.2020-2955
https://doi.org/10.2514/6.2020-2955
Autor:
Bojan Vukasinovic, Bradley Rafferty, Derek A. Nichols, Matthew C. DeFore, Ari Glezer, Francisco D. Palacios
Publikováno v:
AIAA Aviation 2019 Forum.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d13cffc04451c7e0695bff3db756609c
https://doi.org/10.2514/6.2019-3685
https://doi.org/10.2514/6.2019-3685
Publikováno v:
Biomedical Microdevices. 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85f1d8d6b52b2217d252a2636c4d2486
https://doi.org/10.1007/s10544-018-0283-7
https://doi.org/10.1007/s10544-018-0283-7
Publikováno v:
Biomedical Microdevices
Bioreactors are systems that can be used to monitor the response of tissues and cells to candidate drugs. Building on the experience developed in the creation of an osteochondral bioreactor, we have designed a new 3D printed system, which allows opti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d04b441e6c88c8f72c0d791b716e9eb
http://hdl.handle.net/11311/1044757
http://hdl.handle.net/11311/1044757
Autor:
Kyle DeFrees, K.K. Wang, H.L. Woodcock, Emmanuel W. Smith, Fabio Prati, Adam R. Renslo, Derek A. Nichols, Priyadarshini Jaishankar, Jacqueline C. Hargis, Yu Chen, Ruslan Sanishvili
Publikováno v:
Journal of the American Chemical Society, vol 137, iss 25
Ligand binding can change the pKa of protein residues and influence enzyme catalysis. Herein, we report three ultrahigh resolution X-ray crystal structures of CTX-M β-lactamase, directly visualizing protonation state changes along the enzymatic path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64c4f1029a7464ef880b3052ed1fb65
https://doi.org/10.1021/jacs.5b00749
https://doi.org/10.1021/jacs.5b00749