Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Derek A. Mann"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Immunosenescence describes dysregulation of the immune system with ageing manifested in both the innate and adaptive immunity, including changes in T-cell checkpoint signaling. Through complex and nuanced process, T-cells lose excitatory signaling pa
Externí odkaz:
https://doaj.org/article/80621d0f56b74469a81031322b445aed
Autor:
Bhavani Madakashira, Laura Corbett, Chi Zhang, Pier Paoli, John W. Casement, Jelena Mann, Kirsten C. Sadler, Derek A. Mann
Publikováno v:
Epigenetics, Vol 12, Iss 9, Pp 811-824 (2017)
The DNA methylome is re-patterned during discrete phases of vertebrate development. In zebrafish, there are 2 waves of global DNA demethylation and re-methylation: the first occurs before gastrulation when the parental methylome is changed to the zyg
Externí odkaz:
https://doaj.org/article/30b36ccc974e43f180998119acd999d9
Autor:
Mikolaj Ogrodnik, Satomi Miwa, Tamar Tchkonia, Dina Tiniakos, Caroline L. Wilson, Albert Lahat, Christoper P. Day, Alastair Burt, Allyson Palmer, Quentin M. Anstee, Sushma Nagaraja Grellscheid, Jan H J. Hoeijmakers, Sander Barnhoorn, Derek A. Mann, Thomas G. Bird, Wilbert P. Vermeij, James L. Kirkland, João F. Passos, Thomas von Zglinicki, Diana Jurk
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Non-alcoholic fatty liver disease is more common among older individuals. Here, the authors show that senescent cells in the liver promote fat accumulation and steatosis in the liver, and that clearance of senescent cells reduces hepatic steatosis in
Externí odkaz:
https://doaj.org/article/59da7366bd92469288a45b90a4b396f9
Autor:
Francesco Lanucara, Connie Lam, Jelena Mann, Tom P. Monie, Stefano A. P. Colombo, Stephen W. Holman, James Boyd, Manohar C. Dange, Derek A. Mann, Michael R. H. White, Claire E. Eyers
Publikováno v:
Open Biology, Vol 6, Iss 7 (2016)
The NF-κB signalling module controls transcription through a network of protein kinases such as the IKKs, as well as inhibitory proteins (IκBs) and transcription factors including RelA/p65. Phosphorylation of the NF-κB subunits is critical for dic
Externí odkaz:
https://doaj.org/article/a34c79319d2c491f982226bd453d9392
Autor:
Laura Sabater, Jean B. Gossart, Inmaculada Hernandez, Daniel Rico, Andy Blanchard, Lee A. Borthwick, Andrew J. Fisher, Joaquim Majo, Kasim Jiwa, Amy Collins, Giuseppe Abbate, Fiona Oakley, Derek A. Mann, Jelena Mann
Publikováno v:
The American Journal of Pathology. 193:417-429
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5029cf5e9767afff4fb789280af9856a
https://doi.org/10.1016/j.ajpath.2022.12.015
https://doi.org/10.1016/j.ajpath.2022.12.015
Autor:
Bassier Zadran, Praveen Dhondurao Sudhindar, Daniel Wainwright, Yvonne Bury, Saimir Luli, Rachel Howarth, Misti Vanette McCain, Robyn Watson, Hannah Huet, Fanni Palinkas, Rolando Berlinguer-Palmini, John Casement, Derek A. Mann, Fiona Oakley, John Lunec, Helen Reeves, Geoffrey J. Faulkner, Ruchi Shukla
Publikováno v:
British Journal of Cancer. 128:1236-1248
Background Molecular characterisation of hepatocellular carcinoma (HCC) is central to the development of novel therapeutic strategies for the disease. We have previously demonstrated mutagenic consequences of Long-Interspersed Nuclear Element-1 (LINE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c90dab2a8ed53492f5015164c5a984f3
https://doi.org/10.1038/s41416-023-02154-9
https://doi.org/10.1038/s41416-023-02154-9
Autor:
Ibone Labiano, Aloña Agirre-Lizaso, Paula Olaizola, Anne Echebarria, Maider Huici-Izagirre, Irene Olaizola, Aitor Esparza-Baquer, Omar Sharif, Elizabeth Hijona, Piotr Milkiewicz, Malgorzata Milkiewicz, Francisco González-Romero, Patricia Aspichueta, Maria J. Monte, Jose J.G. Marin, Mihael Vucur, Tom Luedde, Marco Marzioni, Derek A. Mann, Luis Bujanda, Pedro M. Rodrigues, Jesus M. Banales, Maria J. Perugorria
Publikováno v:
Journal of Hepatology
Backgroundand aims: inflammation, particularly that mediated by bacterial components translocating from the gut to the liver and binding to toll-like receptors (TLRs), is central to cholestatic liver injury. The triggering receptor expressed on myelo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2c60dc6efe95c81adaffe32d01e643
https://doi.org/10.1016/j.jhep.2022.05.044
https://doi.org/10.1016/j.jhep.2022.05.044
Autor:
Amy Collins, Rebecca Scott, Caroline L Wilson, Giuseppe Abbate, Gabrielle Ecclestone, Demi Biddles, Fiona Oakley, Jelena Mann, Derek A Mann, Niall S. Kenneth
Liver fibrosis is the excessive accumulation of extracellular matrix proteins that occurs in most types of chronic liver diseases. Fibrosis is associated with the activation of hepatic stellate cells (HSCs) which transdifferentiate into a myofibrobla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c3e58ae1c2dda8639cd417d5c143776
https://doi.org/10.1101/2023.01.08.523142
https://doi.org/10.1101/2023.01.08.523142
Autor:
Daniel Geh, Erik Ramon-Gil, Maja Laszczewska, Saimir Luli, Amy Collins, Fiona Oakley, Jack Leslie, Helen L. Reeves, Derek A Mann
Publikováno v:
Journal of Hepatology. 77:S640-S642
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90d21b6a8cf5b9073e449426054dcd37
https://doi.org/10.1016/s0168-8278(22)01598-7
https://doi.org/10.1016/s0168-8278(22)01598-7
Autor:
Nicholas S Kalson, Tim M Brock, Massimo Mangino, Stella M Fabiane, Derek A Mann, Lee A Borthwick, David J Deehan, Frances M K Williams
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190120 (2018)
Joint fibrosis affects many synovial joints (including hip, knee and shoulder) causing stiffness and pain. The mechanism of joint fibrosis remains unknown, although genetic factors may contribute. Defects in maintenance of telomere length resulting f
Externí odkaz:
https://doaj.org/article/86af3d93031b461ca728e12e6e6fa6a3