Data from Oncolytic Adenoviral Mutants with E1B19K Gene Deletions Enhance Gemcitabine-induced Apoptosis in Pancreatic Carcinoma Cells and Anti-Tumor Efficacy In vivo

Autor: Gunnel Halldén, Nick R. Lemoine, Enrique Miranda, Derek Davies, Daniel Öberg, Katrina Sweeney, Stephan Leitner

Purpose: Pancreatic adenocarcinoma is a rapidly progressive malignancy that is highly resistant to current chemotherapeutic modalities and almost uniformly fatal. We show that a novel targeting strategy combining oncolytic adenoviral mutants with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc5029746fc668de01fcb8e38d1b7c1
https://doi.org/10.1158/1078-0432.c.6517719

Supplementary Figure 2 from Mesenchymal Stem Cell Delivery of TRAIL Can Eliminate Metastatic Cancer

Autor: Sam M. Janes, Derek Davies, Ayad Eddaoudi, Michael R. Loebinger

Supplementary Figure 2 from Mesenchymal Stem Cell Delivery of TRAIL Can Eliminate Metastatic Cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5079840b358cefe5b0f3a2e8e5c35b
https://doi.org/10.1158/0008-5472.22378931.v1

Label-free cell cycle analysis for high-throughput imaging flow cytometry

Autor: Thomas Blasi, Holger Hennig, Huw D. Summers, Fabian J. Theis, Joana Cerveira, James O. Patterson, Derek Davies, Andrew Filby, Anne E. Carpenter, Paul Rees

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)

Imaging flow cytometry enables high-throughput acquisition of fluorescence, brightfield and darkfield images of biological cells. Here, Blasi et al.demonstrate that applying machine learning algorithms on brightfield and darkfield images can detect c

Externí odkaz: https://doaj.org/article/64eccd9285fd45858c93a445b1345a3c

DRAQ7 as an Alternative to MTT Assay for Measuring Viability of Glioma Cells Treated With Polyphenols

Autor: Pooja Yashod, Richard Gullan, Harcharan K. Rooprai, Sholeh Keshavarz, Patrick Lawrence, Derek Davies, Richard Selway

Publikováno v: Anticancer Res

BACKGROUND/AIM: The tetrazolium-based MTT cytotoxicity assay is well established for screening putative anti-cancer agents. However, it has limitations including lack of reproducibility with glioma cells treated with polyphenols. The aim of this stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357c08aecff71551fd90ea5356bb7baf
https://doi.org/10.21873/anticanres.14553

Lrig1 expression identifies airway basal cells with high proliferative capacity and restricts lung squamous cell carcinoma growth

Autor: Kim B. Jensen, Sandra Gómez-López, Adam Pennycuick, Ahmed S. N. Alhendi, Laura Succony, Derek Davies, Kate H.C. Gowers, Nicholas A. Wright, Sam M. Janes, Sarah E. Clarke

Publikováno v: Succony, L, Gómez-López, S, Pennycuick, A, Alhendi, A S N, Davies, D, Clarke, S E, Gowers, K H C, Wright, N A, Jensen, K B & Janes, S M 2022, ' Lrig1 expression identifies airway basal cells with high proliferative capacity and restricts lung squamous cell carcinoma growth ', European Respiratory Journal, vol. 59, 2000816 . https://doi.org/10.1183/13993003.00816-2020

BackgroundLung squamous cell carcinoma (LUSC) accounts for a significant proportion of cancer deaths worldwide, and is preceded by the appearance of progressively disorganised pre-invasive lesions in the airway epithelium. Yet the biological mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bc4b6b060200e4112f574104cd276e
https://curis.ku.dk/portal/da/publications/lrig1-expression-identifies-airway-basal-cells-with-high-proliferative-capacity-and-restricts-lung-squamous-cell-carcinoma-growth(19158daa-0781-4fc7-afb2-694cf6b6c016).html